Tut1 ELISA Kit for Mouse(Mus musculus) | EIAab.comTut1 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Tut1(Gene name) > Mouse

Tut1 (Gene name),

Speckle targeted PIP5K1A-regulated poly(A) polymerase (Protein name ), STPAP_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Tut1(Rbm21);

Protein name:

Speckle targeted PIP5K1A-regulated poly(A) polymerase(Star-PAP);

Alternative:

2.7.7.52;U6 snRNA-specific terminal uridylyltransferase 1(U6-TUTase);RNA-binding motif protein 21(RNA-binding protein 21);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Associates with the cleavage and polyadenylation specificity factor (CPSF) complex. Interacts with CPSF1 and CPSF3; the interaction is direct. Interacts with PIP5K1A; interaction.

Function:

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.

Subcellular Location:

Nucleus nucleolus Nucleus speckle

Protein Attributes:

Sequence length:

869

Sequence:

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