Gene name:
STRADB (PRO1038;ALS2CR2;ILPIP) ;
Protein name:
STE20-related kinase adapter protein beta (STRAD beta) ;
Alternative:
CALS-21 ;Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein ;Pseudokinase ALS2CR2 ;ILP-interacting protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.
Function:
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
Subcellular Location:
Nucleus
Cytoplasm
Protein Attributes:
50:
MSLLDCFCTS | RTQVESLRPE | KQSETSIHQY | LVDEPTLSWS | RPSTRASEVL |
100:
CSTNVSHYEL | QVEIGRGFDN | LTSVHLARHT | PTGTLVTIKI | TNLENCNEER |
150:
LKALQKAVIL | SHFFRHPNIT | TYWTVFTVGS | WLWVISPFMA | YGSASQLLRT |
200:
YFPEGMSETL | IRNILFGAVR | GLNYLHQNGC | IHRSIKASHI | LISGDGLVTL |
250:
SGLSHLHSLV | KHGQRHRAVY | DFPQFSTSVQ | PWLSPELLRQ | DLHGYNVKSD |
300:
IYSVGITACE | LASGQVPFQD | MHRTQMLLQK | LKGPPYSPLD | ISIFPQSESR |
350:
MKNSQSGVDS | GIGESVLVSS | GTHTVNSDRL | HTPSSKTFSP | AFFSLVQLCL |
400:
QQDPEKRPSA | SSLLSHVFFK | QMKEESQDSI | LSLLPPAYNK | PSISLPPVLP |
418:
WTEPECDFPD | EKDSYWEF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human STRAD beta
ELISA Kit for Human STRAD beta
CLIA Kit for Human STRAD beta
CLIA Kit for Human STRAD beta
Polyclonal Antibody for Human STRAD beta
Polyclonal Antibody for Human STRAD beta
Monoclonal Antibody for Human STRAD beta
Monoclonal Antibody for Human STRAD beta
Protein for Human STRAD beta
Protein for Human STRAD beta
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] GLU-155 AND LEU-386