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Index > Protein center > STRADB(Gene name) > Human
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  • STRADB (Gene name),
  • STE20-related kinase adapter protein beta (Protein name ),  STRAB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    STRADB(PRO1038;ALS2CR2;ILPIP);
    Protein name:
    STE20-related kinase adapter protein beta(STRAD beta);
    Alternative:
    CALS-21;Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein;Pseudokinase ALS2CR2;ILP-interacting protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.
    Function:
    Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
    Subcellular Location:
    Nucleus Cytoplasm
    Protein Attributes:
    Sequence length:
    418
    Sequence:
    50:
    MSLLDCFCTS | RTQVESLRPE | KQSETSIHQY | LVDEPTLSWS | RPSTRASEVL | 
    100:
    CSTNVSHYEL | QVEIGRGFDN | LTSVHLARHT | PTGTLVTIKI | TNLENCNEER | 
    150:
    LKALQKAVIL | SHFFRHPNIT | TYWTVFTVGS | WLWVISPFMA | YGSASQLLRT | 
    200:
    YFPEGMSETL | IRNILFGAVR | GLNYLHQNGC | IHRSIKASHI | LISGDGLVTL | 
    250:
    SGLSHLHSLV | KHGQRHRAVY | DFPQFSTSVQ | PWLSPELLRQ | DLHGYNVKSD | 
    300:
    IYSVGITACE | LASGQVPFQD | MHRTQMLLQK | LKGPPYSPLD | ISIFPQSESR | 
    350:
    MKNSQSGVDS | GIGESVLVSS | GTHTVNSDRL | HTPSSKTFSP | AFFSLVQLCL | 
    400:
    QQDPEKRPSA | SSLLSHVFFK | QMKEESQDSI | LSLLPPAYNK | PSISLPPVLP | 
    418:
    WTEPECDFPD | EKDSYWEF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    KEGG:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human STRAD beta
    ELISA Kit for Human STRAD beta
    CLIA Kit for Human STRAD beta
    CLIA Kit for Human STRAD beta
    Polyclonal Antibody for Human STRAD beta
    Polyclonal Antibody for Human STRAD beta
    Monoclonal Antibody for Human STRAD beta
    Monoclonal Antibody for Human STRAD beta
    Protein for Human STRAD beta
    Protein for Human STRAD beta

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."
      Hadano S. , Yanagisawa Y. , Skaug J. , Fichter K. , Nasir J. , Martindale D. , Koop B.F. , Scherer S.W. , Nicholson D.W. , Rouleau G.A. , Ikeda J.-E. , Hayden M.R.
      Genomics71:200-213(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    2. 2.
      "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis."
      Sanna M.G. , Da Silva Correia J. , Luo Y. , Chuang B. , Paulson L.M. , Nguyen B. , Deveraux Q.L. , Ulevitch R.J.
      J. Biol. Chem.277:30454-30462(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);TISSUE SPECIFICITY;INTERACTION WITH BIRC4
    3. 3.
      "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C. , Yu Y. , Zhang S. , Wei H. , Zhou G. , Ouyang S. , Luo L. , Bi J. , Liu M. , He F.
      Submitted (1998-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Fetal liver.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Placenta.
    7. 7.
      "MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm."
      Boudeau J. , Baas A.F. , Deak M. , Morrice N.A. , Kieloch A. , Schutkowski M. , Prescott A.R. , Clevers H.C. , Alessi D.R.
      EMBO J.22:5102-5114(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH STK11/LKB1 AND CAB39
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