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Index > Protein center > Stx4(Gene name) > Mouse
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  • Stx4 (Gene name),
  • Syntaxin-4 (Protein name ),  STX4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Stx4(Stx4a);
    Protein name:
    Syntaxin-4;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with STXBP6. Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis (By similarity). Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2.
    Function:
    Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones.
    Subcellular Location:
    Cell membrane Single-pass type IV membrane protein
    Protein Attributes:
    Sequence length:
    298
    Sequence:
    50:
    MRDRTHELRQ | GDNISDDEDE | VRVALVVHSG | AARLGSPDDE | FFQKVQTIRQ | 
    100:
    TMAKLESKVR | ELEKQQVTIL | ATPLPEESMK | QGLQNLREEI | KQLGREVRAQ | 
    150:
    LKAIEPQKEE | ADENYNSVNT | RMKKTQHGVL | SQQFVELINK | CNSMQSEYRE | 
    200:
    KNVERIRRQL | KITNAGMVSD | EELEQMLDSG | QSEVFVSNIL | KDTQVTRQAL | 
    250:
    NEISARHSEI | QQLERSIREL | HEIFTFLATE | VEMQGEMINR | IEKNILSSAD | 
    298:
    YVERGQEHVK | IALENQKKAR | KKKVMIAICV | SVTVLILAVI | IGITITVG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Syntaxin-4
    ELISA Kit for Mouse Syntaxin-4
    ELISA Kit for Mouse Syntaxin-4
    ELISA Kit for Mouse Syntaxin-4
    CLIA Kit for Mouse Syntaxin-4
    CLIA Kit for Mouse Syntaxin-4
    CLIA Kit for Mouse Syntaxin-4
    CLIA Kit for Mouse Syntaxin-4
    Polyclonal Antibody for Mouse Syntaxin-4
    Polyclonal Antibody for Mouse Syntaxin-4
    Polyclonal Antibody for Mouse Syntaxin-4
    Polyclonal Antibody for Mouse Syntaxin-4
    Monoclonal Antibody for Mouse Syntaxin-4
    Monoclonal Antibody for Mouse Syntaxin-4
    Monoclonal Antibody for Mouse Syntaxin-4
    Monoclonal Antibody for Mouse Syntaxin-4
    Protein for Mouse Syntaxin-4
    Protein for Mouse Syntaxin-4
    Protein for Mouse Syntaxin-4
    Protein for Mouse Syntaxin-4

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    Precision
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    Linearity
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    References
    1. 1.
      "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4."
      Tellam J.T. , Macaulay S.L. , McIntosh S. , Hewish D.R. , Ward C.W. , James D.E.
      J. Biol. Chem.272:6179-6186(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH STXB3;SUBCELLULAR LOCATION
      tissue: Adipocyte.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Olfactory bulb.
      tissue: Placenta.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      strain: Czech II.
      strain: FVB/N.
      tissue: Brain.
      tissue: Mammary gland.
    4. 4.
      "Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes."
      Min J. , Okada S. , Kanzaki M. , Elmendorf J.S. , Coker K.J. , Ceresa B.P. , Syu L.-J. , Noda Y. , Saltiel A.R. , Pessin J.E.
      Mol. Cell3:751-760(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH STXBP4; SNAP23 AND VAMP2
    5. 5.
      "Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells."
      Buxton P. , Zhang X.-M. , Walsh B. , Sriratana A. , Schenberg I. , Manickam E. , Rowe T.
      Biochem. J.375:433-440(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNAP23 AND SNAPIN
    6. 6.
      "A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells."
      Wang C.-C. , Ng C.P. , Lu L. , Atlashkin V. , Zhang W. , Seet L.-F. , Hong W.
      Dev. Cell7:359-371(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH VAMP8 AND SNAP23
    7. 7.
      "Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells."
      Musch A. , Cohen D. , Yeaman C. , Nelson W.J. , Rodriguez-Boulan E. , Brennwald P.J.
      Mol. Biol. Cell13:158-168(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LLGL1
    8. 8.
      "Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis."
      Ke B. , Oh E. , Thurmond D.C.
      J. Biol. Chem.282:21786-21797(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STXBP3 AND VAMP2
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    10. 10.
      "Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport."
      Pooley R.D. , Moynihan K.L. , Soukoulis V. , Reddy S. , Francis R. , Lo C. , Ma L.-J. , Bader D.M.
      J. Cell Sci.121:3413-3421(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CENPF;SUBCELLULAR LOCATION
    11. 11.
      "DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes."
      Fukuda N. , Emoto M. , Nakamori Y. , Taguchi A. , Miyamoto S. , Uraki S. , Oka Y. , Tanizawa Y.
      Diabetes58:377-384(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOC2B
    12. 12.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-29 AND SER-248;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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