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Index > Protein center > SUMO2(Gene name) > Human
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  • SUMO2 (Gene name),
  • Small ubiquitin-related modifier 2 (Protein name ),  SUMO2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SUMO2(SMT3A;SMT3H2);
    Protein name:
    Small ubiquitin-related modifier 2(SUMO-2);
    Alternative:
    SMT3 homolog 2;HSMT3;Sentrin-2;SUMO-3;Ubiquitin-like protein SMT3A(Smt3A);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25.
    Function:
    Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
    Subcellular Location:
    Nucleus Nuclear bodies.
    Protein Attributes:
    Sequence length:
    95
    Sequence:
    50:
    MADEKPKEGV | KTENNDHINL | KVAGQDGSVV | QFKIKRHTPL | SKLMKAYCER | 
    95:
    QGLSVRQIRF | RFDGQPINET | DTPAQLEMED | EDTIDVFQQQ | TGGVY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    UniGene:
    String:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human SUMO-2
    ELISA Kit for Human SUMO-2
    ELISA Kit for Human SUMO-2
    ELISA Kit for Human SUMO-2
    ELISA Kit for Human SUMO-2
    ELISA Kit for Human SUMO-2
    CLIA Kit for Human SUMO-2
    CLIA Kit for Human SUMO-2
    CLIA Kit for Human SUMO-2
    CLIA Kit for Human SUMO-2
    CLIA Kit for Human SUMO-2
    CLIA Kit for Human SUMO-2
    Polyclonal Antibody for Human SUMO-2
    Polyclonal Antibody for Human SUMO-2
    Polyclonal Antibody for Human SUMO-2
    Polyclonal Antibody for Human SUMO-2
    Polyclonal Antibody for Human SUMO-2
    Polyclonal Antibody for Human SUMO-2
    Monoclonal Antibody for Human SUMO-2
    Monoclonal Antibody for Human SUMO-2
    Monoclonal Antibody for Human SUMO-2
    Monoclonal Antibody for Human SUMO-2
    Monoclonal Antibody for Human SUMO-2
    Monoclonal Antibody for Human SUMO-2
    Protein for Human SUMO-2
    Protein for Human SUMO-2
    Protein for Human SUMO-2
    Protein for Human SUMO-2
    Protein for Human SUMO-2
    Protein for Human SUMO-2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene."
      Mannen H. , Tseng H.M. , Cho C.L. , Li S.S.-L.
      Biochem. Biophys. Res. Commun.222:178-180(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family."
      Lapenta V. , Chiurazzi P. , van der Spek P.J. , Pizzuti A. , Hanaoka F. , Brahe C.
      Genomics40:362-367(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cerebellum.
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ASN-16
      tissue: Blood vessel.
      tissue: Bone.
      tissue: Bone marrow.
      tissue: Brain.
      tissue: Lung.
      tissue: Skin.
      tissue: Testis.
    6. 7.
      "Characterization of a second member of the sentrin family of ubiquitin-like proteins."
      Kamitani T. , Kito K. , Nguyen H.P. , Fukuda-Kamitani T. , Yeh E.T.H.
      J. Biol. Chem.273:11349-11353(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROTEOLYTIC CLEAVAGE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    7. 8.
      "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3."
      Saitoh H. , Hinchey J.
      J. Biol. Chem.275:6252-6258(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;NOMENCLATURE
    8. 9.
      "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9."
      Tatham M.H. , Jaffray E. , Vaughan O.A. , Desterro J.M.P. , Botting C.H. , Naismith J.H. , Hay R.T.
      J. Biol. Chem.276:35368-35374(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-11;MUTAGENESIS OF LYS-11
    9. 10.
      "Molecular features of human ubiquitin-like SUMO genes and their encoded proteins."
      Su H.-L. , Li S.S.-L.
      Gene296:65-73(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    10. 11.
      "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation."
      Tatham M.H. , Kim S. , Yu B. , Jaffray E. , Song J. , Zheng J. , Rodriguez M.S. , Hay R.T. , Chen Y.
      Biochemistry42:9959-9969(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2I
    11. 12.
      "A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex."
      Reverter D. , Lima C.D.
      Structure12:1519-1531(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE
    12. 13.
      "Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1."
      Xu Z. , Au S.W.N.
      Biochem. J.386:325-330(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE
    13. 14.
      "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression."
      Rosendorff A. , Sakakibara S. , Lu S. , Kieff E. , Xuan Y. , DiBacco A. , Shi Y. , Shi Y. , Gill G.
      Proc. Natl. Acad. Sci. U.S.A.103:5308-5313(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELP1
    14. 15.
      "Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25."
      Meulmeester E. , Kunze M. , Hsiao H.H. , Urlaub H. , Melchior F.
      Mol. Cell30:610-619(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SUMOYLATION OF USP25;INTERACTION WITH USP25
    15. 16.
      "RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation."
      Tatham M.H. , Geoffroy M.C. , Shen L. , Plechanovova A. , Hattersley N. , Jaffray E.G. , Palvimo J.J. , Hay R.T.
      Nat. Cell Biol.10:538-546(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;POLYUBIQUITINATION AT LYS-11 BY RNF4
    16. 17.
      "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
      Blomster H.A. , Imanishi S.Y. , Siimes J. , Kastu J. , Morrice N.A. , Eriksson J.E. , Sistonen L.
      J. Biol. Chem.285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-11
      tissue: Cervix carcinoma.
    17. 18.
      "SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."
      Cong L. , Pakala S.B. , Ohshiro K. , Li D.Q. , Kumar R.
      J. Biol. Chem.286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MTA1;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-33; LYS-35 AND LYS-42
    18. 19.
      "The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA."
      Rabellino A. , Carter B. , Konstantinidou G. , Wu S.Y. , Rimessi A. , Byers L.A. , Heymach J.V. , Girard L. , Chiang C.M. , Teruya-Feldstein J. , Scaglioni P.P.
      Cancer Res.72:2275-2284(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    19. 20.
      "PolySUMO-binding proteins identified through a string search."
      Sun H. , Hunter T.
      J. Biol. Chem.287:42071-42083(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF REPEAT SUMO-INTERACTING MOTIF;INTERACTION WITH SIMC1; CASP8AP2; RNF111 AND SOBP
    20. 21.
      "Ube2W conjugates ubiquitin to alpha-amino groups of protein N-termini."
      Tatham M.H. , Plechanovova A. , Jaffray E.G. , Salmen H. , Hay R.T.
      Biochem. J.453:137-145(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT MET-1
    21. 22.
      "Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins."
      Huang W.-C. , Ko T.-P. , Li S.S.-L. , Wang A.H.-J.
      Eur. J. Biochem.271:4114-4122(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 9-93;SUBUNIT
    22. 23.
      "Solution structure of human SUMO-2 (SMT3B), a ubiquitin-like protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-08) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-93
    23. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-93 CONJUGATED TO TDG
    24. 25.
      "Solution structure of human small ubiquitin-like modifier protein isoform 2 (SUMO-2)."
      Chang C.K. , Wang Y.H. , Chung T.L. , Chang C.F. , Li S.S.L. , Huang T.H.
      Submitted (2006-10) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-95
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