Gene name:
SUMO2 (SMT3A;SMT3H2) ;
Protein name:
Small ubiquitin-related modifier 2 (SUMO-2) ;
Alternative:
SMT3 homolog 2 ;HSMT3 ;Sentrin-2 ;SUMO-3 ;Ubiquitin-like protein SMT3A (Smt3A) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25.
Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
Subcellular Location:
Nucleus
Nuclear bodies.
Protein Attributes:
50:
MADEKPKEGV | KTENNDHINL | KVAGQDGSVV | QFKIKRHTPL | SKLMKAYCER |
95:
QGLSVRQIRF | RFDGQPINET | DTPAQLEMED | EDTIDVFQQQ | TGGVY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Pig
Mouse
Chicken
Human
Rat
ELISA Kit for Human SUMO-2
ELISA Kit for Human SUMO-2
ELISA Kit for Human SUMO-2
ELISA Kit for Human SUMO-2
ELISA Kit for Human SUMO-2
ELISA Kit for Human SUMO-2
CLIA Kit for Human SUMO-2
CLIA Kit for Human SUMO-2
CLIA Kit for Human SUMO-2
CLIA Kit for Human SUMO-2
CLIA Kit for Human SUMO-2
CLIA Kit for Human SUMO-2
Polyclonal Antibody for Human SUMO-2
Polyclonal Antibody for Human SUMO-2
Polyclonal Antibody for Human SUMO-2
Polyclonal Antibody for Human SUMO-2
Polyclonal Antibody for Human SUMO-2
Polyclonal Antibody for Human SUMO-2
Monoclonal Antibody for Human SUMO-2
Monoclonal Antibody for Human SUMO-2
Monoclonal Antibody for Human SUMO-2
Monoclonal Antibody for Human SUMO-2
Monoclonal Antibody for Human SUMO-2
Monoclonal Antibody for Human SUMO-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Brain .
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Cerebellum .
4.
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
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Nature440:1045-1049(2006)
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
Mural R.J.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ASN-16
tissue :
Blood vessel .
tissue :
Bone .
tissue :
Bone marrow .
tissue :
Brain .
tissue :
Lung .
tissue :
Skin .
tissue :
Testis .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PROTEOLYTIC CLEAVAGE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION;NOMENCLATURE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUMOYLATION AT LYS-11;MUTAGENESIS OF LYS-11
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
11.
"Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation."
Tatham M.H.
,
Kim S.
,
Yu B.
,
Jaffray E.
,
Song J.
,
Zheng J.
,
Rodriguez M.S.
,
Hay R.T.
,
Chen Y.
Biochemistry42:9959-9969(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UBE2I
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CLEAVAGE
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CLEAVAGE
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PELP1
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN SUMOYLATION OF USP25;INTERACTION WITH USP25
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;POLYUBIQUITINATION AT LYS-11 BY RNF4
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUMOYLATION AT LYS-11
tissue :
Cervix carcinoma .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MTA1;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-33; LYS-35 AND LYS-42
19.
"The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA."
Rabellino A.
,
Carter B.
,
Konstantinidou G.
,
Wu S.Y.
,
Rimessi A.
,
Byers L.A.
,
Heymach J.V.
,
Girard L.
,
Chiang C.M.
,
Teruya-Feldstein J.
,
Scaglioni P.P.
Cancer Res.72:2275-2284(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : SUBCELLULAR LOCATION
20.
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Cited for : IDENTIFICATION OF REPEAT SUMO-INTERACTING MOTIF;INTERACTION WITH SIMC1; CASP8AP2; RNF111 AND SOBP
21.
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Cited for : UBIQUITINATION AT MET-1
22.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 9-93;SUBUNIT
23.
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Cited for : STRUCTURE BY NMR OF 1-93
24.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-93 CONJUGATED TO TDG
25.
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Cited for : STRUCTURE BY NMR OF 1-95