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Index > Protein center > SUMO3(Gene name) > Human
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  • SUMO3 (Gene name),
  • Small ubiquitin-related modifier 3 (Protein name ),  SUMO3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SUMO3(SMT3B;SMT3H1);
    Protein name:
    Small ubiquitin-related modifier 3(SUMO-3);
    Alternative:
    SUMO-2;SMT3 homolog 1;Ubiquitin-like protein SMT3B(Smt3B);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Covalently attached to a number of proteins (By similarity). Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I.
    Function:
    Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    103
    Sequence:
    50:
    MSEEKPKEGV | KTENDHINLK | VAGQDGSVVQ | FKIKRHTPLS | KLMKAYCERQ | 
    100:
    GLSMRQIRFR | FDGQPINETD | TPAQLEMEDE | DTIDVFQQQT | GGVPESSLAG | 
    103:
    HSF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    SMR:
    KEGG:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human SUMO-3
    ELISA Kit for Human SUMO-3
    ELISA Kit for Human SUMO-3
    ELISA Kit for Human SUMO-3
    ELISA Kit for Human SUMO-3
    CLIA Kit for Human SUMO-3
    CLIA Kit for Human SUMO-3
    CLIA Kit for Human SUMO-3
    CLIA Kit for Human SUMO-3
    CLIA Kit for Human SUMO-3
    Polyclonal Antibody for Human SUMO-3
    Polyclonal Antibody for Human SUMO-3
    Polyclonal Antibody for Human SUMO-3
    Polyclonal Antibody for Human SUMO-3
    Polyclonal Antibody for Human SUMO-3
    Monoclonal Antibody for Human SUMO-3
    Monoclonal Antibody for Human SUMO-3
    Monoclonal Antibody for Human SUMO-3
    Monoclonal Antibody for Human SUMO-3
    Monoclonal Antibody for Human SUMO-3
    Protein for Human SUMO-3
    Protein for Human SUMO-3
    Protein for Human SUMO-3
    Protein for Human SUMO-3
    Protein for Human SUMO-3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family."
      Lapenta V. , Chiurazzi P. , van der Spek P.J. , Pizzuti A. , Hanaoka F. , Brahe C.
      Genomics40:362-367(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-38
      tissue: Brain.
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain cortex.
    5. 5.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Coronary artery.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Bone marrow.
      tissue: Kidney.
    8. 9.
      "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3."
      Saitoh H. , Hinchey J.
      J. Biol. Chem.275:6252-6258(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
    9. 10.
      "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9."
      Tatham M.H. , Jaffray E. , Vaughan O.A. , Desterro J.M.P. , Botting C.H. , Naismith J.H. , Hay R.T.
      J. Biol. Chem.276:35368-35374(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SUMOYLATION OF PML;POLYSUMOYLATION;INTERACTION WITH SAE1 AND UBE2I;SUMOYLATION AT LYS-11;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF LYS-11
    10. 11.
      "Molecular features of human ubiquitin-like SUMO genes and their encoded proteins."
      Su H.-L. , Li S.S.-L.
      Gene296:65-73(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    11. 12.
      "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation."
      Tatham M.H. , Kim S. , Yu B. , Jaffray E. , Song J. , Zheng J. , Rodriguez M.S. , Hay R.T. , Chen Y.
      Biochemistry42:9959-9969(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2I
    12. 13.
      "A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex."
      Reverter D. , Lima C.D.
      Structure12:1519-1531(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE
    13. 14.
      "Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1."
      Xu Z. , Au S.W.N.
      Biochem. J.386:325-330(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE;TISSUE SPECIFICITY
    14. 15.
      "Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3."
      Gong L. , Yeh E.T.H.
      J. Biol. Chem.281:15869-15877(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE
    15. 16.
      "Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25."
      Meulmeester E. , Kunze M. , Hsiao H.H. , Urlaub H. , Melchior F.
      Mol. Cell30:610-619(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SUMOYLATION OF USP25;INTERACTION WITH USP25;MUTAGENESIS OF ILE-33 AND LYS-34
    16. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 18.
      "SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."
      Cong L. , Pakala S.B. , Ohshiro K. , Li D.Q. , Kumar R.
      J. Biol. Chem.286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    18. 19.
      "Solution structure of human SUMO-3 C47S and its binding surface for Ubc9."
      Ding H. , Xu Y. , Chen Q. , Dai H. , Tang Y. , Wu J. , Shi Y.
      Biochemistry44:2790-2799(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 14-92
    19. 20.
      "The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing."
      Shen L.N. , Dong C. , Liu H. , Naismith J.H. , Hay R.T.
      Biochem. J.397:279-288(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) IN COMPLEX WITH SENP1;CLEAVAGE
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