Svil ELISA Kit for Mouse(Mus musculus) | EIAab.comSvil ELISA Kit for Mouse(Mus musculus)

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Svil (Gene name),

Supervillin (Protein name ), SVIL_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Svil;

Protein name:

Supervillin;

Alternative:

p205/p250;Archvillin;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Associates with F-actin. Interacts with NEB. Interacts with MYH9. Interacts with MYLK. Isoform 2 interacts with TRIP6. Isoform 2 interacts with DYNLT1.

Function:

Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6.

Subcellular Location:

Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Cell projection invadopodium Cell projection podosome Tightly associated with both actin filaments and plasma membranes.

Protein Attributes:

Sequence length:

2170

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2170:

EFNALPTWKQ | VNLKKSKGLF |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00626

UniGene:

Mm.136791

KEGG:

mmu:225115

String:

Q8K4L3

SMR:

Q8K4L3

Uniprot:

Q8K4L3

FOR

ELISA Kit for Mouse Supervillin

CLIA Kit for Mouse Supervillin

Polyclonal Antibody for Mouse Supervillin

Monoclonal Antibody for Mouse Supervillin

Protein for Mouse Supervillin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton."
Oh S.W. , Pope R.K. , Smith K.P. , Crowley J.L. , Nebl T. , Lawrence J.B. , Luna E.J.
J. Cell Sci.116:2261-2275(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Skeletal muscle.
2.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857 AND SER-960;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
3.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-960;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
4.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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