Protein name:
Synaptotagmin-like protein 4 ;
Alternative:
Granuphilin ;Exophilin-2 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B.
Function:
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner.
Subcellular Location:
Membrane
Peripheral membrane protein
Cytoplasmic vesicle
secretory vesicle membrane
Peripheral membrane protein
Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.
Protein Attributes:
50:
MSEILDLSFL | SEMERDLILS | VLQRDEELRK | ADEKRIRRLK | NELLEIKRKG |
100:
AKRGSQHYSD | RTCARCQEGL | GRLISKSNTC | VGCNHLVCRE | CRVLESNGSW |
150:
RCKVCSKEIE | LKKATGDWFY | DQKVNRFAYR | TGSDIIRMSL | RRKPAVNKRE |
200:
TVGQSLLQQT | QMGDIWPGRR | IIQEQQKEQS | VLFEVPKLKS | GKSALEAESE |
250:
SLDSYTADSD | STSRRDSLDK | SGLFPEWKKM | SAPKSQVEKE | IAPGNQNAVC |
300:
GDEGDMIFKK | NTRKVLRPSE | YTKSVIDLRP | EDVAQESGIL | GDRSKSVPGL |
350:
SVDMEDEEEE | EEDIDHLVKL | HRQKLARGSM | QSGSSMSTIG | SMMSLYSEAG |
400:
DFGNVSVTGK | IAFSLKFEQK | TQTLVIHVKE | CHQLAYADEA | KKRSNPYVKT |
450:
YLLPDKSRQG | KRKTSIKRDT | INPLYDETFR | YEISESLLAQ | RTLQFSVWHH |
500:
GRFGRNTFLG | EAEVHMDSWK | LDKKLDHCLP | LHGKISTESS | PGLPAHKGEL |
550:
VVSLKYIPAS | KLPVGGDRKK | SKGGEGGELQ | VWIKEAKNLT | AAKSGGTSDS |
600:
FVKGYLLPMR | NKASKRKTPV | MKKTLNPHYN | HTFVYNGVRL | EDLQHMCLEL |
650:
TVWDREPLAS | NDFLGGVRLG | VGTGISSGEV | VDWMDSTGEE | VSLWQKMRQY |
672:
PGSWAEGTLQ | LRSSMVKQKL | GV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Rat Synaptotagmin-like protein 4
ELISA Kit for Rat Synaptotagmin-like protein 4
ELISA Kit for Rat Synaptotagmin-like protein 4
CLIA Kit for Rat Synaptotagmin-like protein 4
CLIA Kit for Rat Synaptotagmin-like protein 4
CLIA Kit for Rat Synaptotagmin-like protein 4
Polyclonal Antibody for Rat Synaptotagmin-like protein 4
Polyclonal Antibody for Rat Synaptotagmin-like protein 4
Polyclonal Antibody for Rat Synaptotagmin-like protein 4
Monoclonal Antibody for Rat Synaptotagmin-like protein 4
Monoclonal Antibody for Rat Synaptotagmin-like protein 4
Monoclonal Antibody for Rat Synaptotagmin-like protein 4
Protein for Rat Synaptotagmin-like protein 4
Protein for Rat Synaptotagmin-like protein 4
Protein for Rat Synaptotagmin-like protein 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);MUTAGENESIS OF VAL-21 AND LEU-43;INTERACTION WITH RAB3A AND STXBP1;SUBCELLULAR LOCATION
tissue :
Insulinoma .