Gene name:
Taok1 (Kiaa1361) ;
Protein name:
Serine/threonine-protein kinase TAO1 ;
Alternative:
Thousand and one amino acid protein 1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Self-associates. Interacts with MAP2K3. Interacts with SPRED1 and TESK1. Interacts with MAP3K7.
Function:
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MPSTNRAGSL | KDPEIAELFF | KEDPEKLFTD | LREIGHGSFG | AVYFARDVRT |
100:
NEVVAIKKMS | YSGKQSTEKW | QDIIKEVKFL | QRIKHPNSIE | YKGCYLREHT |
150:
AWLVMEYCLG | SASDLLEVHK | KPLQEVEIAA | ITHGALQGLA | YLHSHTMIHR |
200:
DIKAGNILLT | EPGQVKLADF | GSASMASPAN | SFVGTPYWMA | PEVILAMDEG |
250:
QYDGKVDVWS | LGITCIELAE | RKPPLFNMNA | MSALYHIAQN | ESPTLQSNEW |
300:
SDYFRNFVDS | CLQKIPQDRP | TSEELLKHMF | VLRERPETVL | IDLIQRTKDA |
350:
VRELDNLQYR | KMKKLLFQEA | HNGPAVEAQE | EEEEQDHGVG | RTGTVNSVGS |
400:
NQSIPSMSIS | ASSQSSSVNS | LPDASDDKSE | LDMMEGDHTV | MSNSSVIHLK |
450:
PEEENYQEEG | DPRTRASDPQ | SPPQVSRHKS | HYRNREHFAT | IRTASLVTRQ |
500:
MQEHEQDSEL | REQMSGYKRM | RRQHQKQLMT | LENKLKAEMD | EHRLRLDKDL |
550:
ETQRNNFAAE | MEKLIKKHQA | AMEKEAKVMA | NEEKKFQQHI | QAQQKKELNS |
600:
FLESQKREYK | LRKEQLKEEL | NENQSTPKKE | KQEWLSKQKE | NIQHFQAEEE |
650:
ANLLRRQRQY | LELECRRFKR | RMLLGRHNLE | QDLVREELNK | RQTQKDLEHA |
700:
MLLRQHESMQ | ELEFRHLNTI | QKMRCELIRL | QHQTELTNQL | EYNKRREREL |
750:
RRKHVMEVRQ | QPKSLKSKEL | QIKKQFQDTC | KIQTRQYKAL | RNHLLETTPK |
800:
SEHKAVLKRL | KEEQTRKLAI | LAEQYDHSIN | EMLSTQALRL | DEAQEAECQV |
850:
LKMQLQQELE | LLNAYQSKIK | MQAEAQHDRE | LRELEQRVSL | RRALLEQKIE |
900:
EEMLALQNER | TERIRSLLER | QAREIEAFDS | ESMRLGFSNM | VLSNLSPEAF |
950:
SHSYPGASSW | SHNPTGGPGP | HWGHPMGGTP | QAWGHPMQGG | PQPWGHPSGP |
1000:
MQGVPRGSSM | GVRNSPQALR | RTASGGRTEQ | GMSRSTSVTS | QISNGSHMSY |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Mouse Serine/threonine-protein kinase TAO1
ELISA Kit for Mouse Serine/threonine-protein kinase TAO1
ELISA Kit for Mouse Serine/threonine-protein kinase TAO1
CLIA Kit for Mouse Serine/threonine-protein kinase TAO1
CLIA Kit for Mouse Serine/threonine-protein kinase TAO1
CLIA Kit for Mouse Serine/threonine-protein kinase TAO1
Polyclonal Antibody for Mouse Serine/threonine-protein kinase TAO1
Polyclonal Antibody for Mouse Serine/threonine-protein kinase TAO1
Polyclonal Antibody for Mouse Serine/threonine-protein kinase TAO1
Monoclonal Antibody for Mouse Serine/threonine-protein kinase TAO1
Monoclonal Antibody for Mouse Serine/threonine-protein kinase TAO1
Monoclonal Antibody for Mouse Serine/threonine-protein kinase TAO1
Protein for Mouse Serine/threonine-protein kinase TAO1
Protein for Mouse Serine/threonine-protein kinase TAO1
Protein for Mouse Serine/threonine-protein kinase TAO1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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