Protein name:
Tenascin (TN) ;
Alternative:
Tenascin-C (TN-C) ;Hexabrachion ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
Function:
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MGAVTWLLPG | IFLALFALTP | EGGVLKKIIR | HKRESGLNMT | LPEENQPVVF |
100:
NHIYNIKLPM | GSQCSVDLES | ASGEKDLTPT | PESSGSFQEH | TVDGENQIVF |
150:
THRINIPRRA | CGCAAAPDVK | ELLSRLEELE | LLVSSLREQC | TMGTGCCLQP |
200:
AEGRLDTRPF | CSGRGNFSAE | GCGCVCEPGW | KGPNCSEPDC | PGNCNLRGQC |
250:
LDGQCICDEG | FTGEDCSQLA | CPNDCNDQGR | CVNGVCVCFE | GYAGPDCGLE |
300:
VCPVPCSEEH | GMCVDGRCVC | KDGFAGEDCN | EPLCLNNCYN | RGRCVENECV |
350:
CDEGFTGEDC | SELICPNDCF | DRGRCINGTC | YCEEGFTGED | CGELTCPNDC |
400:
QGRGQCEEGQ | CVCNEGFAGA | DCSEKRCPAD | CHHRGRCLNG | QCECDDGFTG |
450:
ADCGDLQCPN | GCSGHGRCVN | GQCVCDEGYT | GEDCSQRRCP | NDCHNRGLCV |
500:
QGKCICEQGF | KGFDCSEMSC | PNDCHQHGRC | VNGMCICDDD | YTGEDCRDRR |
550:
CPRDCSQRGR | CVDGQCICED | GFTGPDCAEL | SCPSDCHGHG | RCVNGQCICH |
600:
EGFTGKDCKE | QRCPSDCHGQ | GRCEDGQCIC | HEGFTGLDCG | QRSCPNDCSN |
650:
QGQCVSGRCI | CNEGYTGIDC | SEVSPPKDLI | VTEVTEETVN | LAWDNEMRVT |
700:
EYLIMYTPTH | ADGLEMQFRV | PGDQTSTTIR | ELEPGVEYFI | RVFAILENKR |
750:
SIPVSARVAT | YLPAPEGLKF | KSIKETSVEV | EWDPLDIAFE | TWEIIFRNMN |
800:
KEDEGEITKS | LRRPETSYRQ | TGLAPGQEYE | ISLHIVKNNT | RGPGLKKVTT |
850:
TRLDAPSHIE | VKDVTDTTAL | ITWFKPLAEI | DSIELSYGIK | DVPGDRTTID |
900:
LTHEDNQYSI | GNLRPDTEYE | VSLISRRVDM | ASNPAKETFI | TGLDAPRNLR |
950:
RVSQTDNSIT | LEWRNVKADI | DSYRIKYAPI | SGGDHAEIDV | PKSQQATTKT |
1000:
TLTGLRPGTE | YGIGVSAVKG | DKESDPATIN | AATEIDAPKD | LRVSETTQDS |
1050:
LTFFWTTPLA | KFDRYRLNYS | LPTGQSMEVQ | LPKDATSHVL | TDLEPGQEYT |
1100:
VLLIAEKGRH | KSKPARVKAS | TEEVPSLENL | TVTEAGWDGL | RLNWTADDLA |
1150:
YEYFVIQVQE | ANNVETAHNF | TVPGNLRAAD | IPGLKVATSY | RVSIYGVARG |
1200:
YRTPVLSAET | STGTTPNLGE | VTVAEVGWDA | LTLNWTAPEG | AYKNFFIQVL |
1250:
EADTTQTVQN | LTVPGGLRSV | DLPGLKAATR | YYITLRGVTQ | DFGTAPLSVE |
1300:
VLTEDLPQLG | GLSVTEVSWD | GLTLNWTTDD | LAYKHFVVQV | QEANNVEAAQ |
1350:
NLTVPGSLRA | VDIPGLKADT | PYRVSIYGVI | QGYRTPMLST | DVSTAREPEI |
1400:
GNLNVSDVTP | KSFNLSWTAT | DGIFDMFTIE | IIDSNRLLQT | AEHNISGAER |
1450:
TAHISGLPPS | TDFIVYLSGI | APSIRTKTIS | TTATTEALPL | LENLTISDTN |
1500:
PYGFTVSWTA | SENAFDSFLV | TVVDSGKLLD | PQEFTLSGTQ | RKLELRGLIT |
1550:
GIGYEVLVSG | FTQGHQTKPL | RAETITEAEP | EVDNLLVSDA | TPDGFRLSWT |
1600:
ADEGIFDSFV | IRIRDTKKQS | EPQEISLPSP | ERTRDITGLR | EATEYEIELY |
1650:
GISRGRRSQP | VSAIATTAMG | SPKEIMFSDI | TENAATVSWR | APTAQVESFR |
1700:
ITYVPMTGGA | PSMVTVDGTD | TETRLVKLTP | GVEYRVSVIA | MKGFEESDPV |
1750:
SGTLITALDG | PSGLLIANIT | DSEALAMWQP | AIATVDSYVI | SYTGERVPEV |
1800:
TRTVSGNTVE | YELHDLEPAT | EYILSIFAEK | GQQKSSTIAT | KFTTDLDSPR |
1850:
EFTATEVQSE | TALLTWRPPR | ASVTGYLLVY | ESVDGTVKEV | IVGPDTTSYS |
1900:
LADLSPSTHY | SARIQALSGS | LRSKLIQTIF | TTIGLLYPFP | RDCSQAMLNG |
1950:
DTTSGLYTIY | INGDKTQALE | VYCDMTSDGG | GWIVFLRRKN | GREDFYRNWK |
2000:
AYAAGFGDRR | EEFWLGLDNL | SKITAQGQYE | LRVDLQDHGE | SAYAVYDRFS |
2050:
VGDAKSRYKL | KVEGYSGTAG | DSMNYHNGRS | FSTYDKDTDS | AITNCALSYK |
2100:
GAFWYKNCHR | VNLMGRYGDN | NHSQGVNWFH | WKGHEYSIQF | AEMKLRPSNF |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Pig
Chicken
Polyclonal Antibody for Mouse TN
Polyclonal Antibody for Mouse TN
Polyclonal Antibody for Mouse TN
Polyclonal Antibody for Mouse TN
Monoclonal Antibody for Mouse TN
Monoclonal Antibody for Mouse TN
Monoclonal Antibody for Mouse TN
Monoclonal Antibody for Mouse TN
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain :
GRS .
tissue :
Mammary tumor .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5);DEVELOPMENTAL STAGE;GLYCOSYLATION
strain :
NMRI X 129 .
tissue :
Embryo .
3.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1394
strain :
C57BL/6 .
tissue :
Plasma .