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Index > Protein center > Tep1(Gene name) > Mouse
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  • Tep1 (Gene name),
  • Telomerase protein component 1 (Protein name ),  TEP1_MOUSE from NCBI database.
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  • Gene name:
    Tep1(Tp1);
    Protein name:
    Telomerase protein component 1;
    Alternative:
    p240;Telomerase-associated protein 1(Telomerase protein 1);p80 telomerase homolog;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.
    Function:
    Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.
    Subcellular Location:
    Nucleus Chromosome telomere
    Protein Attributes:
    Sequence length:
    2629
    Sequence:
    50:
    MEKLCGHVPG | HSDILSLKNR | CLTMLPDLQP | LEKIHGHRSV | HSDILSLENQ | 
    100:
    CLTMLSDLQP | TERIDGHISV | HPDILSLENR | CLTMLPDLQP | LEKLCGHMSS | 
    150:
    HPDVLSLENQ | CLATLPTVKS | TALTSPLLQG | LHISHTAQAD | LHSLKTSNCL | 
    200:
    LPELPTKKTP | CFSEELDLPP | GPRALKSMSA | TAQVQEVALG | QWCVSKEKEF | 
    250:
    QEEESTEVPM | PLYSLSLEEE | EVEAPVLKLT | SGDSGFHPET | TDQVLQEKKM | 
    300:
    ALLTLLCSAL | ASNVNVKDAS | DLTRASILEV | CSALASLEPE | FILKASLYAR | 
    350:
    QQLNLRDIAN | TVLAVAALLP | ACRPHVRRYY | SAIVHLPSDW | IQVAEFYQSL | 
    400:
    AEGDEKKLVS | LPACLRAAMT | DKFAEFDEYQ | LAKYNPRKHR | SKRRSRQPPR | 
    450:
    PQKTERPFSE | RGKCFPKSLW | PLKNEQITFE | AAYNAMPEKN | RLPRFTLKKL | 
    500:
    VEYLHIHKPA | QHVQALLGYR | YPATLELFSR | SHLPGPWESS | RAGQRMKLRR | 
    550:
    PETWERELSL | RGNKASVWEE | LIDNGKLPFM | AMLRNLCNLL | RTGISARHHE | 
    600:
    LVLQRLQHEK | SVVHSRQFPF | RFLNAHDSID | KLEAQLRSKA | SPFPSNTTLM | 
    650:
    KRIMIRNSKK | NRRPASRKHL | CTLTRRQLRA | AMTIPVMYEQ | LKREKLRLHK | 
    700:
    ARQWNCDVEL | LERYRQALET | AVNLSVKHNL | SPMPGRTLLV | YLTDANADRL | 
    750:
    CPKSHSQGPP | LNYVLLLIGM | MVARAEQVTV | CLCGGGFVKT | PVLTADEGIL | 
    800:
    KTAIKLQAQV | QELEGNDEWP | LDTFGKYLLS | LAVQRTPIDR | VILFGQRMDT | 
    850:
    ELLKVAKQII | WQHVNSKCLF | VGVLLQKTQY | ISPNLNPNDV | TLSGCTDGIL | 
    900:
    KFIAEHGASR | LLEHVGQLDK | LFKIPPPPGK | TQAPSLRPLE | ENIPGPLGPI | 
    950:
    SQHGWRNIRL | FISSTFRDMH | GERDLLMRSV | LPALQARVFP | HRISLHAIDL | 
    1000:
    RWGITEEETR | RNRQLEVCLG | EVENSQLFVG | ILGSRYGYIP | PSYDLPDHPH | 
    1050:
    FHWTHEYPSG | RSVTEMEVMQ | FLNRGQRSQP | SAQALIYFRD | PDFLSSVPDA | 
    1100:
    WKPDFISESE | EAAHRVSELK | RYLHEQKEVT | CRSYSCEWGG | VAAGRPYTGG | 
    1150:
    LEEFGQLVLQ | DVWSMIQKQH | LQPGAQLEQP | TSISEDDLIQ | TSFQQLKTPT | 
    1200:
    SPARPRLLQD | TVQQLLLPHG | RLSLVTGQAG | QGKTAFLASL | VSALKVPDQP | 
    1250:
    NEPPFVFFHF | AAARPDQCLA | LNLLRRLCTH | LRQKLGELSA | LPSTYRGLVW | 
    1300:
    ELQQKLLLKF | AQSLQPAQTL | VLIIDGADKL | VDRNGQLISD | WIPKSLPRRV | 
    1350:
    HLVLSVSSDS | GLGETLQQSQ | GAYVVALGSL | VPSSRAQLVR | EELALYGKRL | 
    1400:
    EESPFNNQMR | LLLAKQGSSL | PLYLHLVTDY | LRLFTLYEQV | SERLRTLPAT | 
    1450:
    LPLLLQHILS | TLEQEHGHDV | LPQALTALEV | TRSGLTVDQL | HAILSTWLIL | 
    1500:
    PKETKSWEEV | LAASHSGNPF | PLCPFAYLVQ | SLRSLLGEGP | VERPGARLCL | 
    1550:
    SDGPLRTTIK | RRYGKRLGLE | KTAHVLIAAH | LWKTCDPDAS | GTFRSCPPEA | 
    1600:
    LKDLPYHLLQ | SGNHGLLAEF | LTNLHVVAAY | LEVGLVPDLL | EAHVLYASSK | 
    1650:
    PEANQKLPAA | DVAVFHTFLR | QQASLLTQYP | LLLLQQAASQ | PEESPVCCQA | 
    1700:
    PLLTQRWHDQ | FTLKWINKPQ | TLKGQQSLSL | TMSSSPTAVA | FSPNGQRAAV | 
    1750:
    GTASGTIYLL | NLKTWQEEKA | VVSGCDGISS | FAFLSDTALF | LTTFDGHLEL | 
    1800:
    WDLQHGCWVF | QTKAHQYQIT | GCCLSPDRRL | LATVCLGGYL | KLWDTVRGQL | 
    1850:
    AFQYTHPKSL | NCVAFHPEGQ | VVATGSWAGS | ITFFQADGLK | VTKELGAPGP | 
    1900:
    SVCSLAFNKP | GKIVAVGRID | GTVELWAWQE | GARLAAFPAQ | CGCVSAVLFL | 
    1950:
    HAGDRFLTAG | EDGKAQLWSG | FLGRPRGCLG | SLPLSPALSV | ALNPDGDQVA | 
    2000:
    VGYREDGINI | YKISSGSQGP | QHQELNVAVS | ALVWLSPSVL | VSGAEDGSLH | 
    2050:
    GWMFKGDSLH | SLWLLSRYQK | PVLGLAASRE | LMAAASEDFT | VRLWPRQLLT | 
    2100:
    QPHVHAVELP | CCAELRGHEG | PVCCCSFSPD | GGILATAGRD | RNLLCWDMKI | 
    2150:
    AQAPLLIHTF | SSCHRDWITG | CAWTKDNILV | SCSSDGSVGL | WNPEAGQQLG | 
    2200:
    QFSGHQSAVS | AVVAVEEHIV | SVSRDGTLKV | WDHQGVELTS | IPAHSGPISQ | 
    2250:
    CAAALEPRPG | GQPGSELLVV | TVGLDGATKL | WHPLLVCQIR | TLQGHSGPVT | 
    2300:
    AAAASEASGL | LLTSDDSSVQ | LWQIPKEADD | SYKPRSSVAI | TAVAWAPDGS | 
    2350:
    MVVSGNEAGE | LTLWQQAKAV | ATAQAPGRVS | HLIWYSANSF | FVLSANENVS | 
    2400:
    EWQVGLRKGS | TSTSSSLHLK | RVLQEDWGVL | TGLGLAPDGQ | SLILMKEDVE | 
    2450:
    LLEMKPGSIP | SSICRRYGVH | SSILCTSKEY | GLFYLQQGDS | GLLSILEQKE | 
    2500:
    SGEFEEILDF | NLNLNNPNGS | PVSITQAKPE | SESSLLCATS | DGMLWNLSEC | 
    2550:
    TSEGEWIVDN | IWQKKAKKPK | TQTLETELSP | HSELDFSIDC | WIDPTNLKAQ | 
    2600:
    QCKKIHLGSV | TALHVLPGLL | VTASKDRDVK | LWERPSMQLL | GLFRCEGPVS | 
    2629:
    CLEPWMEPSS | PLQLAVGDTQ | GNLYFLSWE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    Pfam:
    String:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Telomerase protein component 1
    Cat.:
    E0558h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Telomerase protein component 1
    Cat.:
    E0558r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Telomerase protein component 1
    Cat.:
    E0558m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Telomerase protein component 1
    Cat.:
    U0558h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Telomerase protein component 1
    Cat.:
    U0558m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Telomerase protein component 1
    Cat.:
    U0558r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Telomerase protein component 1
    Cat.:
    P0558Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Telomerase protein component 1
    Cat.:
    P0558Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Telomerase protein component 1
    Cat.:
    P0558Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Telomerase protein component 1
    Monoclonal Antibody for Mouse Telomerase protein component 1
    Monoclonal Antibody for Mouse Telomerase protein component 1
    Protein for Mouse Telomerase protein component 1
    Cat.:
    R0558h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Mouse Telomerase protein component 1
    Protein for Mouse Telomerase protein component 1

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;RNA-BINDING;IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX
    2. 2.
      "TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family."
      Nakayama J. , Saito M. , Nakamura H. , Matsuura A. , Ishikawa F.
      Cell88:875-884(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA-BINDING
    4. 4.
      "The telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle."
      Kickhoefer V.A. , Liu Y. , Kong L.B. , Snow B.E. , Stewart P.L. , Harrington L. , Rome L.H.
      J. Cell Biol.152:157-164(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VAULT RNA LOCALIZATION/STABILIZATION;IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE
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