Protein name:
Telomerase protein component 1 ;
Alternative:
p240 ;Telomerase-associated protein 1 (Telomerase protein 1) ;p80 telomerase homolog ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.
Function:
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.
Subcellular Location:
Nucleus
Chromosome
telomere
Protein Attributes:
50:
MEKLCGHVPG | HSDILSLKNR | CLTMLPDLQP | LEKIHGHRSV | HSDILSLENQ |
100:
CLTMLSDLQP | TERIDGHISV | HPDILSLENR | CLTMLPDLQP | LEKLCGHMSS |
150:
HPDVLSLENQ | CLATLPTVKS | TALTSPLLQG | LHISHTAQAD | LHSLKTSNCL |
200:
LPELPTKKTP | CFSEELDLPP | GPRALKSMSA | TAQVQEVALG | QWCVSKEKEF |
250:
QEEESTEVPM | PLYSLSLEEE | EVEAPVLKLT | SGDSGFHPET | TDQVLQEKKM |
300:
ALLTLLCSAL | ASNVNVKDAS | DLTRASILEV | CSALASLEPE | FILKASLYAR |
350:
QQLNLRDIAN | TVLAVAALLP | ACRPHVRRYY | SAIVHLPSDW | IQVAEFYQSL |
400:
AEGDEKKLVS | LPACLRAAMT | DKFAEFDEYQ | LAKYNPRKHR | SKRRSRQPPR |
450:
PQKTERPFSE | RGKCFPKSLW | PLKNEQITFE | AAYNAMPEKN | RLPRFTLKKL |
500:
VEYLHIHKPA | QHVQALLGYR | YPATLELFSR | SHLPGPWESS | RAGQRMKLRR |
550:
PETWERELSL | RGNKASVWEE | LIDNGKLPFM | AMLRNLCNLL | RTGISARHHE |
600:
LVLQRLQHEK | SVVHSRQFPF | RFLNAHDSID | KLEAQLRSKA | SPFPSNTTLM |
650:
KRIMIRNSKK | NRRPASRKHL | CTLTRRQLRA | AMTIPVMYEQ | LKREKLRLHK |
700:
ARQWNCDVEL | LERYRQALET | AVNLSVKHNL | SPMPGRTLLV | YLTDANADRL |
750:
CPKSHSQGPP | LNYVLLLIGM | MVARAEQVTV | CLCGGGFVKT | PVLTADEGIL |
800:
KTAIKLQAQV | QELEGNDEWP | LDTFGKYLLS | LAVQRTPIDR | VILFGQRMDT |
850:
ELLKVAKQII | WQHVNSKCLF | VGVLLQKTQY | ISPNLNPNDV | TLSGCTDGIL |
900:
KFIAEHGASR | LLEHVGQLDK | LFKIPPPPGK | TQAPSLRPLE | ENIPGPLGPI |
950:
SQHGWRNIRL | FISSTFRDMH | GERDLLMRSV | LPALQARVFP | HRISLHAIDL |
1000:
RWGITEEETR | RNRQLEVCLG | EVENSQLFVG | ILGSRYGYIP | PSYDLPDHPH |
1050:
FHWTHEYPSG | RSVTEMEVMQ | FLNRGQRSQP | SAQALIYFRD | PDFLSSVPDA |
1100:
WKPDFISESE | EAAHRVSELK | RYLHEQKEVT | CRSYSCEWGG | VAAGRPYTGG |
1150:
LEEFGQLVLQ | DVWSMIQKQH | LQPGAQLEQP | TSISEDDLIQ | TSFQQLKTPT |
1200:
SPARPRLLQD | TVQQLLLPHG | RLSLVTGQAG | QGKTAFLASL | VSALKVPDQP |
1250:
NEPPFVFFHF | AAARPDQCLA | LNLLRRLCTH | LRQKLGELSA | LPSTYRGLVW |
1300:
ELQQKLLLKF | AQSLQPAQTL | VLIIDGADKL | VDRNGQLISD | WIPKSLPRRV |
1350:
HLVLSVSSDS | GLGETLQQSQ | GAYVVALGSL | VPSSRAQLVR | EELALYGKRL |
1400:
EESPFNNQMR | LLLAKQGSSL | PLYLHLVTDY | LRLFTLYEQV | SERLRTLPAT |
1450:
LPLLLQHILS | TLEQEHGHDV | LPQALTALEV | TRSGLTVDQL | HAILSTWLIL |
1500:
PKETKSWEEV | LAASHSGNPF | PLCPFAYLVQ | SLRSLLGEGP | VERPGARLCL |
1550:
SDGPLRTTIK | RRYGKRLGLE | KTAHVLIAAH | LWKTCDPDAS | GTFRSCPPEA |
1600:
LKDLPYHLLQ | SGNHGLLAEF | LTNLHVVAAY | LEVGLVPDLL | EAHVLYASSK |
1650:
PEANQKLPAA | DVAVFHTFLR | QQASLLTQYP | LLLLQQAASQ | PEESPVCCQA |
1700:
PLLTQRWHDQ | FTLKWINKPQ | TLKGQQSLSL | TMSSSPTAVA | FSPNGQRAAV |
1750:
GTASGTIYLL | NLKTWQEEKA | VVSGCDGISS | FAFLSDTALF | LTTFDGHLEL |
1800:
WDLQHGCWVF | QTKAHQYQIT | GCCLSPDRRL | LATVCLGGYL | KLWDTVRGQL |
1850:
AFQYTHPKSL | NCVAFHPEGQ | VVATGSWAGS | ITFFQADGLK | VTKELGAPGP |
1900:
SVCSLAFNKP | GKIVAVGRID | GTVELWAWQE | GARLAAFPAQ | CGCVSAVLFL |
1950:
HAGDRFLTAG | EDGKAQLWSG | FLGRPRGCLG | SLPLSPALSV | ALNPDGDQVA |
2000:
VGYREDGINI | YKISSGSQGP | QHQELNVAVS | ALVWLSPSVL | VSGAEDGSLH |
2050:
GWMFKGDSLH | SLWLLSRYQK | PVLGLAASRE | LMAAASEDFT | VRLWPRQLLT |
2100:
QPHVHAVELP | CCAELRGHEG | PVCCCSFSPD | GGILATAGRD | RNLLCWDMKI |
2150:
AQAPLLIHTF | SSCHRDWITG | CAWTKDNILV | SCSSDGSVGL | WNPEAGQQLG |
2200:
QFSGHQSAVS | AVVAVEEHIV | SVSRDGTLKV | WDHQGVELTS | IPAHSGPISQ |
2250:
CAAALEPRPG | GQPGSELLVV | TVGLDGATKL | WHPLLVCQIR | TLQGHSGPVT |
2300:
AAAASEASGL | LLTSDDSSVQ | LWQIPKEADD | SYKPRSSVAI | TAVAWAPDGS |
2350:
MVVSGNEAGE | LTLWQQAKAV | ATAQAPGRVS | HLIWYSANSF | FVLSANENVS |
2400:
EWQVGLRKGS | TSTSSSLHLK | RVLQEDWGVL | TGLGLAPDGQ | SLILMKEDVE |
2450:
LLEMKPGSIP | SSICRRYGVH | SSILCTSKEY | GLFYLQQGDS | GLLSILEQKE |
2500:
SGEFEEILDF | NLNLNNPNGS | PVSITQAKPE | SESSLLCATS | DGMLWNLSEC |
2550:
TSEGEWIVDN | IWQKKAKKPK | TQTLETELSP | HSELDFSIDC | WIDPTNLKAQ |
2600:
QCKKIHLGSV | TALHVLPGLL | VTASKDRDVK | LWERPSMQLL | GLFRCEGPVS |
2629:
CLEPWMEPSS | PLQLAVGDTQ | GNLYFLSWE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Mouse Telomerase protein component 1
ELISA Kit for Mouse Telomerase protein component 1
ELISA Kit for Mouse Telomerase protein component 1
CLIA Kit for Mouse Telomerase protein component 1
CLIA Kit for Mouse Telomerase protein component 1
CLIA Kit for Mouse Telomerase protein component 1
Polyclonal Antibody for Mouse Telomerase protein component 1
Polyclonal Antibody for Mouse Telomerase protein component 1
Polyclonal Antibody for Mouse Telomerase protein component 1
Monoclonal Antibody for Mouse Telomerase protein component 1
Monoclonal Antibody for Mouse Telomerase protein component 1
Monoclonal Antibody for Mouse Telomerase protein component 1
Protein for Mouse Telomerase protein component 1
Protein for Mouse Telomerase protein component 1
Protein for Mouse Telomerase protein component 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;RNA-BINDING;IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : RNA-BINDING
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN VAULT RNA LOCALIZATION/STABILIZATION;IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE