TCF3 ELISA Kit for Human(Homo sapiens) | EIAab.comTCF3 ELISA Kit for Human(Homo sapiens)

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TCF3 (Gene name),

Transcription factor E2-alpha (Protein name ), TFE2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TCF3(BHLHB21;E2A;ITF1);

Protein name:

Transcription factor E2-alpha;

Alternative:

Immunoglobulin enhancer-binding factor E12/E47;Class B basic helix-loop-helix protein 21(bHLHb21);Kappa-E2-binding factor;Immunoglobulin transcription factor 1;Transcription factor ITF-1;Transcription factor 3(TCF-3);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with RALGAPA1 and FIGLA. Efficient DNA binding requires dimerization with another bHLH protein. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with NEUROD2, PTF1A and TGFB1I1 (By similarity). Homodimer. Heterodimer. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Interacts with EP300 and UBE2I.

Function:

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

654

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

654:

AGHM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000262965

KEGG:

hsa:6929

UniGene:

Hs.371282

String:

P15923

SMR:

P15923

MIM:

147141

Pfam:

PF00010

Uniprot:

P15923

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ELISA Kit for Human Transcription factor E2-alpha

Cat.:

E14975h

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96T

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ELISA Kit for Human Transcription factor E2-alpha

MSDS:

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ELISA Kit for Human Transcription factor E2-alpha

Cat.:

E14975m

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MSDS:

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Packing:

96T

CLIA Kit for Human Transcription factor E2-alpha

Cat.:

U14975m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Transcription factor E2-alpha

MSDS:

Please sign in first.

CLIA Kit for Human Transcription factor E2-alpha

Cat.:

U14975h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Transcription factor E2-alpha

Monoclonal Antibody for Human Transcription factor E2-alpha

Protein for Human Transcription factor E2-alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL."
Kamps M.P. , Murre C. , Sun X.-H. , Baltimore D.
Cell60:547-555(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E12);CHROMOSOMAL TRANSLOCATION WITH PBX1
2.

"Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor."
Nourse J. , Mellentin J.D. , Galili N. , Wilkinson J. , Stanbridge E. , Smith S.D. , Cleary M.L.
Cell60:535-545(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E12)
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS E47 AND 3)
5.

"A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins."
Murre C. , McCaw P.S. , Baltimore D.
Cell56:777-783(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 214-654 (ISOFORMS E12 AND E47);DOMAIN BHLH
tissue: Lymphoma.
6.

"Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor."
Henthorn P. , McCarrick-Walmsley R. , Kadesch T.
Nucleic Acids Res.18:677-677(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-654 (ISOFORM E47)
7.

"Sequence of a HeLa cDNA provides the DNA binding domain and carboxy terminus of HE47: a human helix-loop-helix protein related to the enhancer binding factor E47."
Zhang Y. , Bina M.
DNA Seq.2:197-202(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 511-654 (ISOFORM E47)
8.

"Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif."
Henthorn P. , Kiledjian M. , Kadesch T.
Science247:467-470(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISCUSSION OF SEQUENCE
9.

"Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains."
Voronova A. , Baltimore D.
Proc. Natl. Acad. Sci. U.S.A.87:4722-4726(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS;DNA-BINDING;HOMODIMERIZATION
10.

"The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias."
Hunger S.P. , Galili N. , Carroll A.J. , Crist W.M. , Link M.P. , Cleary M.L.
Blood77:687-693(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH PBX1
11.

"Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia."
Inaba T. , Roberts W.M. , Shapiro L.H. , Jolly K.W. , Raimondi S.C. , Smith S.D. , Look A.T.
Science257:531-534(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH HLF
12.

"The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors."
Loveys D.A. , Streiff M.B. , Schaefer T.S. , Kato G.J.
Gene201:169-177(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2I
13.

"Identification of a novel molecular partner of the E2A gene in childhood leukemia."
Brambillasca F. , Mosna G. , Colombo M. , Rivolta A. , Caslini C. , Minuzzo M. , Giudici G. , Mizzi L. , Biondi A. , Privitera E.
Leukemia13:369-375(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH TFPT
14.

"Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD."
Kim J.Y. , Chu K. , Kim H.J. , Seong H.A. , Park K.C. , Sanyal S. , Takeda J. , Ha H. , Shong M. , Tsai M.J. , Choi H.S.
Mol. Endocrinol.18:776-790(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEUROD1 AND EP300;HOMODIMERIZATION;HETERODIMERIZATION
15.

"Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary."
Bayne R.A.L. , Martins da Silva S.J. , Anderson R.A.
Mol. Hum. Reprod.10:373-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FIGLA
16.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-531 (ISOFORM E47);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139 AND SER-359;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Proposed structure for the DNA-binding domain of the helix-loop-helix family of eukaryotic gene regulatory proteins."
Gibson T.J. , Thompson J.D. , Abagyan R.A.
Protein Eng.6:41-50(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 549-610
22.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-8
23.

"Nine-amino-acid transactivation domain: establishment and prediction utilities."
Piskacek S. , Gregor M. , Nemethova M. , Grabner M. , Kovarik P. , Piskacek M.
Genomics89:756-768(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN

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