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Index > Protein center > TCF3(Gene name) > Human
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  • TCF3 (Gene name),
  • Transcription factor E2-alpha (Protein name ),  TFE2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TCF3(BHLHB21;E2A;ITF1);
    Protein name:
    Transcription factor E2-alpha;
    Alternative:
    Immunoglobulin enhancer-binding factor E12/E47;Class B basic helix-loop-helix protein 21(bHLHb21);Kappa-E2-binding factor;Immunoglobulin transcription factor 1;Transcription factor ITF-1;Transcription factor 3(TCF-3);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with RALGAPA1 and FIGLA. Efficient DNA binding requires dimerization with another bHLH protein. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with NEUROD2, PTF1A and TGFB1I1 (By similarity). Homodimer. Heterodimer. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Interacts with EP300 and UBE2I.
    Function:
    Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    654
    Sequence:
    50:
    MNQPQRMAPV | GTDKELSDLL | DFSMMFPLPV | TNGKGRPASL | AGAQFGGSGL | 
    100:
    EDRPSSGSWG | SGDQSSSSFD | PSRTFSEGTH | FTESHSSLSS | STFLGPGLGG | 
    150:
    KSGERGAYAS | FGRDAGVGGL | TQAGFLSGEL | ALNSPGPLSP | SGMKGTSQYY | 
    200:
    PSYSGSSRRR | AADGSLDTQP | KKVRKVPPGL | PSSVYPPSSG | EDYGRDATAY | 
    250:
    PSAKTPSSTY | PAPFYVADGS | LHPSAELWSP | PGQAGFGPML | GGGSSPLPLP | 
    300:
    PGSGPVGSSG | SSSTFGGLHQ | HERMGYQLHG | AEVNGGLPSA | SSFSSAPGAT | 
    350:
    YGGVSSHTPP | VSGADSLLGS | RGTTAGSSGD | ALGKALASIY | SPDHSSNNFS | 
    400:
    SSPSTPVGSP | QGLAGTSQWP | RAGAPGALSP | SYDGGLHGLQ | SKIEDHLDEA | 
    450:
    IHVLRSHAVG | TAGDMHTLLP | GHGALASGFT | GPMSLGGRHA | GLVGGSHPED | 
    500:
    GLAGSTSLMH | NHAALPSQPG | TLPDLSRPPD | SYSGLGRAGA | TAAASEIKRE | 
    550:
    EKEDEENTSA | ADHSEEEKKE | LKAPRARTSP | DEDEDDLLPP | EQKAEREKER | 
    600:
    RVANNARERL | RVRDINEAFK | ELGRMCQLHL | NSEKPQTKLL | ILHQAVSVIL | 
    650:
    NLEQQVRERN | LNPKAACLKR | REEEKVSGVV | GDPQMVLSAP | HPGLSEAHNP | 
    654:
    AGHM
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    SMR:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Transcription factor E2-alpha
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    E14975h
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    ELISA Kit for Human Transcription factor E2-alpha
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    ELISA Kit for Human Transcription factor E2-alpha
    Cat.:
    E14975m
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    Packing:
    96T
    CLIA Kit for Human Transcription factor E2-alpha
    Cat.:
    U14975m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Transcription factor E2-alpha
    MSDS:
    Please sign in first.
    CLIA Kit for Human Transcription factor E2-alpha
    Cat.:
    U14975h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Transcription factor E2-alpha
    Polyclonal Antibody for Human Transcription factor E2-alpha
    Polyclonal Antibody for Human Transcription factor E2-alpha
    Monoclonal Antibody for Human Transcription factor E2-alpha
    Monoclonal Antibody for Human Transcription factor E2-alpha
    Monoclonal Antibody for Human Transcription factor E2-alpha
    Protein for Human Transcription factor E2-alpha
    Protein for Human Transcription factor E2-alpha
    Protein for Human Transcription factor E2-alpha

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
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      "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL."
      Kamps M.P. , Murre C. , Sun X.-H. , Baltimore D.
      Cell60:547-555(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E12);CHROMOSOMAL TRANSLOCATION WITH PBX1
    2. 2.
      "Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor."
      Nourse J. , Mellentin J.D. , Galili N. , Wilkinson J. , Stanbridge E. , Smith S.D. , Cleary M.L.
      Cell60:535-545(1990) [PubMed] [Europe PMC] [Abstract]
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    3. 3.
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      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS E47 AND 3)
    5. 5.
      "A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins."
      Murre C. , McCaw P.S. , Baltimore D.
      Cell56:777-783(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 214-654 (ISOFORMS E12 AND E47);DOMAIN BHLH
      tissue: Lymphoma.
    6. 6.
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      Henthorn P. , McCarrick-Walmsley R. , Kadesch T.
      Nucleic Acids Res.18:677-677(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-654 (ISOFORM E47)
    7. 7.
      "Sequence of a HeLa cDNA provides the DNA binding domain and carboxy terminus of HE47: a human helix-loop-helix protein related to the enhancer binding factor E47."
      Zhang Y. , Bina M.
      DNA Seq.2:197-202(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 511-654 (ISOFORM E47)
    8. 8.
      "Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif."
      Henthorn P. , Kiledjian M. , Kadesch T.
      Science247:467-470(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISCUSSION OF SEQUENCE
    9. 9.
      "Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains."
      Voronova A. , Baltimore D.
      Proc. Natl. Acad. Sci. U.S.A.87:4722-4726(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS;DNA-BINDING;HOMODIMERIZATION
    10. 10.
      "The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias."
      Hunger S.P. , Galili N. , Carroll A.J. , Crist W.M. , Link M.P. , Cleary M.L.
      Blood77:687-693(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH PBX1
    11. 11.
      "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia."
      Inaba T. , Roberts W.M. , Shapiro L.H. , Jolly K.W. , Raimondi S.C. , Smith S.D. , Look A.T.
      Science257:531-534(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH HLF
    12. 12.
      "The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors."
      Loveys D.A. , Streiff M.B. , Schaefer T.S. , Kato G.J.
      Gene201:169-177(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2I
    13. 13.
      "Identification of a novel molecular partner of the E2A gene in childhood leukemia."
      Brambillasca F. , Mosna G. , Colombo M. , Rivolta A. , Caslini C. , Minuzzo M. , Giudici G. , Mizzi L. , Biondi A. , Privitera E.
      Leukemia13:369-375(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH TFPT
    14. 14.
      "Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD."
      Kim J.Y. , Chu K. , Kim H.J. , Seong H.A. , Park K.C. , Sanyal S. , Takeda J. , Ha H. , Shong M. , Tsai M.J. , Choi H.S.
      Mol. Endocrinol.18:776-790(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEUROD1 AND EP300;HOMODIMERIZATION;HETERODIMERIZATION
    15. 15.
      "Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary."
      Bayne R.A.L. , Martins da Silva S.J. , Anderson R.A.
      Mol. Hum. Reprod.10:373-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FIGLA
    16. 16.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-531 (ISOFORM E47);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139 AND SER-359;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    19. 19.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Proposed structure for the DNA-binding domain of the helix-loop-helix family of eukaryotic gene regulatory proteins."
      Gibson T.J. , Thompson J.D. , Abagyan R.A.
      Protein Eng.6:41-50(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 549-610
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-8
    23. 23.
      "Nine-amino-acid transactivation domain: establishment and prediction utilities."
      Piskacek S. , Gregor M. , Nemethova M. , Grabner M. , Kovarik P. , Piskacek M.
      Genomics89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
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