TFPI ELISA Kit for Human(Homo sapiens) | EIAab.comTFPI ELISA Kit for Human(Homo sapiens)

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TFPI (Gene name),

Tissue factor pathway inhibitor (Protein name ), TFPI1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

TFPI(LACI;TFPI1);

Protein name:

Tissue factor pathway inhibitor(TFPI);

Alternative:

Lipoprotein-associated coagulation inhibitor(LACI);Extrinsic pathway inhibitor(EPI);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

304

Sequence:

50:

100:

150:

200:

250:

300:

304:

VKNM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.516578

SMR:

P10646

MIM:

152310

KEGG:

hsa:7035

STRING:

9606.ENSP00000233156

String:

P10646

Pfam:

PF00014

Uniprot:

P10646

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ELISA Kit for Human TFPI

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ELISA Kit for Human TFPI

Cat.:

E0394h

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96T

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ELISA Kit for Human TFPI

Cat.:

E0394m

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96T

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ELISA Kit for Human TFPI

Cat.:

E0394r

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96T

CLIA Kit for Human TFPI

Cat.:

U0394m

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96T

CLIA Kit for Human TFPI

Cat.:

U0394r

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Packing:

96T

CLIA Kit for Human TFPI

Cat.:

U0394h

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96T

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CLIA Kit for Human TFPI

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Polyclonal Antibody for Human TFPI

Cat.:

P0394Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human TFPI

Cat.:

P0394Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human TFPI

Cat.:

P0394Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human TFPI

Protein for Human TFPI

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains."
Wun T.-C. , Kretzmer K.K. , Girard T.J. , Miletich J.P. , Broze G.J. Jr.
J. Biol. Chem.263:6001-6004(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
2.

"Identification of the 1.4 kb and 4.0 kb messages for the lipoprotein associated coagulation inhibitor and expression of the encoded protein."
Girard T.J. , Warren L.A. , Novotny W.F. , Bejcek B.E. , Miletich J.P. , Broze G.J. Jr.
Thromb. Res.55:37-50(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
3.

"Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation."
van der Logt C.P.E. , Reitsma P.H. , Bertina R.M.
Biochemistry30:1571-1577(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA)
4.

"Structure of the human lipoprotein-associated coagulation inhibitor gene. Intro/exon gene organization and localization of the gene to chromosome 2."
Girard T.J. , Eddy R. , Wesselschmidt R.L. , Macphail L.A. , Likert K.M. , Byers M.G. , Shows T.B. , Broze G.J. Jr.
J. Biol. Chem.266:5036-5041(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA)
5.

Chang J.-Y. , Monroe D.M. , Roberts H.R.
Submitted (1997-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA)
6.

SeattleSNPs variation discovery resource
Submitted (2003-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA)
tissue: Pancreas.
10.

"Biochemical characterization of plasma-derived tissue factor pathway inhibitor: post-translational modification of free, full-length form with particular reference to the sugar chain."
Mori Y. , Hamuro T. , Nakashima T. , Hamamoto T. , Natsuka S. , Hase S. , Iwanaga S.
J. Thromb. Haemost.7:111-120(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-304;IDENTIFICATION BY MASS SPECTROMETRY;GLYCOSYLATION AT THR-42; ASN-145; ASN-195; SER-202 AND THR-203
11.

"Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma."
Novotny W.F. , Girard T.J. , Miletich J.P. , Broze G.J. Jr.
J. Biol. Chem.264:18832-18837(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-50
12.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-43
13.

"Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor."
Girard T.J. , Warren L.A. , Novotny W.F. , Likert K.M. , Brown S.G. , Miletich J.P. , Broze G.J. Jr.
Nature338:518-520(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITORY SITES
14.

"Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: one N- and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in Kunitz domain 2."
Nakahara Y. , Miyata T. , Hamuro T. , Funatsu A. , Miyagi M. , Tsunasawa S. , Kato H.
Biochemistry35:6450-6459(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-145; ASN-195; SER-202 AND THR-203
15.

"Regulation of coagulation by a multivalent Kunitz-type inhibitor."
Broze G.J. Jr. , Girard T.J. , Novotny W.F.
Biochemistry29:7539-7546(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
16.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145
tissue: Plasma.
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"TFPIbeta is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes."
Girard T.J. , Tuley E. , Broze G.J. Jr.
Blood119:1256-1262(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION (ISOFORM BETA);GPI-ANCHOR
19.

"The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition."
Stubbs M.T. , Morenweiser R. , Stuerzebecher J. , Bauer M. , Bode W. , Huber R. , Piechottka G.P. , Matschiner G. , Sommerhoff C.P. , Fritz H. , Auerswald E.A.
J. Biol. Chem.272:19931-19937(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 121-178 IN COMPLEX WITH TRYPSIN
20.

"The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa."
Burgering M.J.M. , Orbons L.P.M. , van der Doelen A. , Mulders J. , Theunissen H.J.M. , Grootenhuis P.D.J. , Bode W. , Huber R. , Stubbs M.T.
J. Mol. Biol.269:395-407(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 121-182
21.

"Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor."
Mine S. , Yamazaki T. , Miyata T. , Hara S. , Kato H.
Biochemistry41:78-85(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 210-270
22.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-292
23.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM

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