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Index > Protein center > TGFB3(Gene name) > Human
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  • TGFB3 (Gene name),
  • Transforming growth factor beta-3 (Protein name ),  TGFB3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    TGFB3;
    Protein name:
    Transforming growth factor beta-3(TGF-beta-3);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Interacts with ASPN.
    Function:
    Involved in embryogenesis and cell differentiation.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    412
    Sequence:
    50:
    MKMHLQRALV | VLALLNFATV | SLSLSTCTTL | DFGHIKKKRV | EAIRGQILSK | 
    100:
    LRLTSPPEPT | VMTHVPYQVL | ALYNSTRELL | EEMHGEREEG | CTQENTESEY | 
    150:
    YAKEIHKFDM | IQGLAEHNEL | AVCPKGITSK | VFRFNVSSVE | KNRTNLFRAE | 
    200:
    FRVLRVPNPS | SKRNEQRIEL | FQILRPDEHI | AKQRYIGGKN | LPTRGTAEWL | 
    250:
    SFDVTDTVRE | WLLRRESNLG | LEISIHCPCH | TFQPNGDILE | NIHEVMEIKF | 
    300:
    KGVDNEDDHG | RGDLGRLKKQ | KDHHNPHLIL | MMIPPHRLDN | PGQGGQRKKR | 
    350:
    ALDTNYCFRN | LEENCCVRPL | YIDFRQDLGW | KWVHEPKGYY | ANFCSGPCPY | 
    400:
    LRSADTTHST | VLGLYNTLNP | EASASPCCVP | QDLEPLTILY | YVGRTPKVEQ | 
    412:
    LSNMVVKSCK | CS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    KEGG:
    MIM:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human TGF-beta-3
    Cat.:
    E1215r
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human TGF-beta-3
    Cat.:
    E1215m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human TGF-beta-3
    Cat.:
    E1215h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human TGF-beta-3
    Cat.:
    E1215p
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human TGF-beta-3
    Cat.:
    E1215c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human TGF-beta-3
    Cat.:
    U1215h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human TGF-beta-3
    Cat.:
    U1215c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TGF-beta-3
    Cat.:
    U1215r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TGF-beta-3
    Cat.:
    U1215m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TGF-beta-3
    Cat.:
    U1215p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human TGF-beta-3
    Polyclonal Antibody for Human TGF-beta-3
    Cat.:
    P1215Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TGF-beta-3
    Cat.:
    P1215Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TGF-beta-3
    Polyclonal Antibody for Human TGF-beta-3
    Cat.:
    P1215Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human TGF-beta-3
    Monoclonal Antibody for Human TGF-beta-3
    Monoclonal Antibody for Human TGF-beta-3
    Monoclonal Antibody for Human TGF-beta-3
    Monoclonal Antibody for Human TGF-beta-3
    Protein for Human TGF-beta-3
    Protein for Human TGF-beta-3
    Protein for Human TGF-beta-3
    Protein for Human TGF-beta-3
    Protein for Human TGF-beta-3

    R&D Technical Data

    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤6.7%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤10.6%

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    Recovery

    Recovery was determined by spiking various levels of TGFB3 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    103

    95-105

    Plasma

    104

    98-108

     

     

     

     

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of TGFB3 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    100-105%

    98-107%

    100-106%

    97-108%

    EDTA plasma(n=5)

    98-108%

    97-108%

    98-106%

    97-107%

    heparin plasma(n=5)

    98-106%

    95-110%

    96-107%

    98-109%

     

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    References
    1. 1.
      "Identification of another member of the transforming growth factor type beta gene family."
      ten Dijke P. , Hansen P. , Iwata K. , Pieler C. , Foulkes J.G.
      Proc. Natl. Acad. Sci. U.S.A.85:4715-4719(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    3. 3.
      "Complete genomic sequence of human transforming growth factor-beta 3."
      Madan A. , Rowen L. , Qin S. , Dickhoff R. , Shaffer T. , James R. , Abbasi N. , Loretz C. , Madan A. , Dors M. , Dahl T. , Hall J. , Lasky S. , Hood L.
      Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      NIEHS SNPs program
      Submitted (2002-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-60
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    7. 7.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Prostate.
    9. 9.
      "Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region."
      Arrick B.A. , Lee A.L. , Grendell R.L. , Derynck R.
      Mol. Cell. Biol.11:4306-4313(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-48 (ISOFORM 1/2)
    10. 10.
      "Mechanisms for asporin function and regulation in articular cartilage."
      Nakajima M. , Kizawa H. , Saitoh M. , Kou I. , Miyazono K. , Ikegawa S.
      J. Biol. Chem.282:32185-32192(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASPN
    11. 11.
      "The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding."
      Mittl P.R.E. , Priestle J.P. , Cox D.A. , McMaster G. , Cerletti N. , Gruetter M.G.
      Protein Sci.5:1261-1271(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 301-412
    12. 12.
      "Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1."
      Beffagna G. , Occhi G. , Nava A. , Vitiello L. , Ditadi A. , Basso C. , Bauce B. , Carraro G. , Thiene G. , Towbin J.A. , Danieli G.A. , Rampazzo A.
      Cardiovasc. Res.65:366-373(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ARVD1
    13. 13.
      "A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome."
      Rienhoff H.Y. Jr. , Yeo C.Y. , Morissette R. , Khrebtukova I. , Melnick J. , Luo S. , Leng N. , Kim Y.J. , Schroth G. , Westwick J. , Vogel H. , McDonnell N. , Hall J.G. , Whitman M.
      Am. J. Med. Genet. A161A:2040-2046(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT RNHF TYR-409;CHARACTERIZATION OF VARIANT RNHF TYR-409
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