THRA ELISA Kit for Human(Homo sapiens) | EIAab.comTHRA ELISA Kit for Human(Homo sapiens)

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Index > Protein center > THRA(Gene name) > Human

THRA (Gene name),

Thyroid hormone receptor alpha (Protein name ), THA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

THRA(EAR7;ERBA1;NR1A1;THRA1;THRA2);

Protein name:

Thyroid hormone receptor alpha;

Alternative:

V-erbA-related protein 7(EAR-7);Nuclear receptor subfamily 1 group A member 1;c-erbA-alpha;c-erbA-1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13.

Function:

Nuclear hormone receptor. High affinity receptor for triiodothyronine.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

490

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

490:

GILHARAVCG | EDDSSEADSP | SSSEEEPEVC | EDLAGNAASP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P10827

KEGG:

hsa:7067

STRING:

9606.ENSP00000264637

Pfam:

PF00104

SMR:

P10827

UniGene:

Hs.724

MIM:

190120

Uniprot:

P10827

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ELISA Kit for Human Thyroid hormone receptor alpha

Cat.:

E1927r

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96T

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ELISA Kit for Human Thyroid hormone receptor alpha

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E1927h

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96T

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ELISA Kit for Human Thyroid hormone receptor alpha

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E1927p

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96T

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ELISA Kit for Human Thyroid hormone receptor alpha

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E1927c

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96T

ELISA Kit for Human Thyroid hormone receptor alpha

Cat.:

E1927m

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96T

CLIA Kit for Human Thyroid hormone receptor alpha

Cat.:

U1927h

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96T

CLIA Kit for Human Thyroid hormone receptor alpha

Cat.:

U1927c

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96T

CLIA Kit for Human Thyroid hormone receptor alpha

Cat.:

U1927r

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Packing:

96T

CLIA Kit for Human Thyroid hormone receptor alpha

Cat.:

U1927m

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Packing:

96T

CLIA Kit for Human Thyroid hormone receptor alpha

Cat.:

U1927p

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96T

Polyclonal Antibody for Human Thyroid hormone receptor alpha

Cat.:

P1927Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Thyroid hormone receptor alpha

Cat.:

P1927Rb-m

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Polyclonal Antibody for Human Thyroid hormone receptor alpha

Cat.:

P1927Rb-h

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Polyclonal Antibody for Human Thyroid hormone receptor alpha

Monoclonal Antibody for Human Thyroid hormone receptor alpha

Protein for Human Thyroid hormone receptor alpha

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene."
Laudet V. , Begue A. , Henry C. , Joubel A. , Martin P. , Stehelin D. , Saule S.
Nucleic Acids Res.19:1105-1112(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS ALPHA-1 AND ALPHA-2)
2.

"Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus."
Miyajima N. , Horiuchi R. , Shibuya Y. , Fukushige S. , Matsubara K. , Toyoshima K. , Yamamoto T.
Cell57:31-39(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-1 AND ALPHA-2)
3.

"Characterization of a thyroid hormone receptor expressed in human kidney and other tissues."
Nakai A. , Seino S. , Sakurai A. , Szilak I. , Bell G.I. , Degroot L.J.
Proc. Natl. Acad. Sci. U.S.A.85:2781-2785(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-2)
tissue: Kidney.
4.

"Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor."
Pfahl M. , Benbrook D.
Nucleic Acids Res.15:9613-9613(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-2)
tissue: Testis.
5.

"Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues."
Nakai A. , Sakurai A. , Bell G.I. , Degroot L.J.
Mol. Endocrinol.2:1087-1092(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA-1)
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-2)
tissue: Brain.
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA-2 AND ALPHA-3)
tissue: Brain.
tissue: Hippocampus.
tissue: Muscle.
9.

"A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library."
Benbrook D. , Pfahl M.
Science238:788-791(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-370
10.

Liu C. , Li L. , Liu B. , Zang X.
Submitted (2002-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 280-451 (ISOFORM ALPHA-4)
tissue: Brain cortex.
11.

"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."
Chen H. , Lin R.J. , Schiltz R.L. , Chakravarti D. , Nash A. , Nagy L. , Privalsky M.L. , Nakatani Y. , Evans R.M.
Cell90:569-580(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA3
12.

"Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action."
Rubino D. , Driggers P. , Arbit D. , Kemp L. , Miller B. , Coso O. , Pagliai K. , Gray K. , Gutkind S. , Segars J.
Oncogene16:2513-2526(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKAP13
13.

"A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."
Lee S.-K. , Anzick S.L. , Choi J.-E. , Bubendorf L. , Guan X.-Y. , Jung Y.-K. , Kallioniemi O.-P. , Kononen J. , Trent J.M. , Azorsa D. , Jhun B.-H. , Cheong J.H. , Lee Y.C. , Meltzer P.S. , Lee J.W.
J. Biol. Chem.274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
14.

"Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor."
Borngraeber S. , Budny M.J. , Chiellini G. , Cunha-Lima S.T. , Togashi M. , Webb P. , Baxter J.D. , Scanlan T.S. , Fletterick R.J.
Proc. Natl. Acad. Sci. U.S.A.100:15358-15363(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF SER-277
15.

"Identification of a novel modulator of thyroid hormone receptor-mediated action."
Baumgartner B.G. , Orpinell M. , Duran J. , Ribas V. , Burghardt H.E. , Bach D. , Villar A.V. , Paz J.C. , Gonzalez M. , Camps M. , Oriola J. , Rivera F. , Palacin M. , Zorzano A.
PLoS ONE2:E1183-E1183(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TP53INP2
16.

"Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
Tan F. , Lu L. , Cai Y. , Wang J. , Xie Y. , Wang L. , Gong Y. , Xu B.-E. , Wu J. , Luo Y. , Qiang B. , Yuan J. , Sun X. , Peng X.
Proteomics8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-190
tissue: Cervix carcinoma.
17.

"A mutation in the thyroid hormone receptor alpha gene."
Bochukova E. , Schoenmakers N. , Agostini M. , Schoenmakers E. , Rajanayagam O. , Keogh J.M. , Henning E. , Reinemund J. , Gevers E. , Sarri M. , Downes K. , Offiah A. , Albanese A. , Halsall D. , Schwabe J.W. , Bain M. , Lindley K. , Muntoni F. , more...
N. Engl. J. Med.366:243-249(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CHNG6
18.

"Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1."
Ye L. , Li Y.L. , Mellstrom K. , Mellin C. , Bladh L.G. , Koehler K. , Garg N. , Garcia Collazo A.M. , Litten C. , Husman B. , Persson K. , Ljunggren J. , Grover G. , Sleph P.G. , George R. , Malm J.
J. Med. Chem.46:1580-1588(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 148-370 IN COMPLEX WITH SYNTHETIC AGONIST;FUNCTION
19.

"Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function."
Nascimento A.S. , Dias S.M. , Nunes F.M. , Aparicio R. , Ambrosio A.L. , Bleicher L. , Figueira A.C. , Santos M.A. , de Oliveira Neto M. , Fischer H. , Togashi M. , Craievich A.F. , Garratt R.C. , Baxter J.D. , Webb P. , Polikarpov I.
J. Mol. Biol.360:586-598(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) OF 148-370 IN COMPLEX WITH TRIIODOTHYRONINE;SUBUNIT
20.

"Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms."
Bleicher L. , Aparicio R. , Nunes F.M. , Martinez L. , Gomes Dias S.M. , Figueira A.C. , Santos M.A. , Venturelli W.H. , da Silva R. , Donate P.M. , Neves F.A. , Simeoni L.A. , Baxter J.D. , Webb P. , Skaf M.S. , Polikarpov I.
BMC Struct. Biol.8:8-8(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 148-370 IN COMPLEX WITH SYNTHETIC AGONIST;FUNCTION
21.

"Gaining ligand selectivity in thyroid hormone receptors via entropy."
Martinez L. , Nascimento A.S. , Nunes F.M. , Phillips K. , Aparicio R. , Dias S.M. , Figueira A.C. , Lin J.H. , Nguyen P. , Apriletti J.W. , Neves F.A. , Baxter J.D. , Webb P. , Skaf M.S. , Polikarpov I.
Proc. Natl. Acad. Sci. U.S.A.106:20717-20722(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 148-370 IN COMPLEX WITH SYNTHETIC AGONIST;FUNCTION;MUTAGENESIS OF SER-277

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