TXN ELISA Kit for Human(Homo sapiens) | EIAab.comTXN ELISA Kit for Human(Homo sapiens)

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Index > Protein center > TXN(Gene name) > Human

TXN (Gene name),

Thioredoxin (Protein name ), THIO_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

TXN(TRDX;TRX;TRX1);

Protein name:

Thioredoxin(Trx);

Alternative:

Surface-associated sulphydryl protein(SASP);ATL-derived factor(ADF);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner.

Function:

ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

Subcellular Location:

Nucleus Cytoplasm Secreted Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.

Protein Attributes:

Sequence length:

105

Sequence:

50:

100:

105:

INELV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:7295

MIM:

187700

String:

P10599

Pfam:

PF00085

UniGene:

Hs.435136

SMR:

P10599

STRING:

9606.ENSP00000363641

Uniprot:

P10599

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ELISA Kit for Human Trx

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ELISA Kit for Human Trx

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E0702h

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ELISA Kit for Human Trx

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E0702r

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ELISA Kit for Human Trx

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E0702p

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ELISA Kit for Human Trx

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E0702m

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ELISA Kit for Human Trx

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E0702c

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ELISA Kit for Human Trx

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ELISA Kit for Human Trx

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E0702b

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96T

CLIA Kit for Human Trx

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U0702b

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96T

CLIA Kit for Human Trx

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U0702c

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96T

CLIA Kit for Human Trx

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U0702h

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96T

CLIA Kit for Human Trx

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U0702r

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96T

CLIA Kit for Human Trx

Cat.:

U0702m

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CLIA Kit for Human Trx

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U0702p

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CLIA Kit for Human Trx

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CLIA Kit for Human Trx

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Polyclonal Antibody for Human Trx

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P0702Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Trx

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P0702Rb-r

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Polyclonal Antibody for Human Trx

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P0702Rb-m

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Polyclonal Antibody for Human Trx

Monoclonal Antibody for Human Trx

Protein for Human Trx

R&D Technical Data

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Precision

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Recovery

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Linearity

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Citations

[1].

"The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis"

Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee

From:Human Reproduction

[2].

"Alteration in the intrafollicular thiol–redox system in infertile women with endometriosis"

YS Choi, SH Cho, SK Seo, et al.

From:Reproduction

References

1.

"Cloning and expression of a cDNA for human thioredoxin."
Wollman E.E. , D'Auriol L. , Rimsky L. , Shaw A. , Jacquot J.-P. , Wingfield P. , Graber P. , Dessarps F.
J. Biol. Chem.263:15506-15512(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction."
Tagaya Y. , Maeda Y. , Mitsui A. , Kndo N. , Matsui H. , Hamuro J. , Brown N. , Arai K. , Yokota T. , Wakasugi H. , Yodoi J.
EMBO J.8:757-764(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Isolation and characterization of human thioredoxin-encoding genes."
Tonissen K.F. , Wells J.R.E.
Gene102:221-228(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

Reddy P.G. , Bhuyan D.K. , Bhuyan K.C.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Lens.
5.

"Cloning, purification and characterization of human lens thioredoxin."
Liu A. , Lou M.F.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Lens.
6.

"Cloning and sequencing of thioredoxin cDNA from human brain."
Xu J.Y. , Xu L. , Li K.S. , Dai R.
Submitted (2000-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Cerebellum.
8.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
9.

NIEHS SNPs program
Submitted (2002-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
10.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Cervix.
13.

"An alternative splice variant of human thioredoxin."
Wang Y. , Wang Y.G. , Zhang Y. , Yuan Y. , Ma D.
Chin. Sci. Bull.43:292-295(1998)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-85 (ISOFORM 2);ALTERNATIVE SPLICING
tissue: Liver.
14.

"Characterization of a thioredoxin-related surface protein."
Dean M.F. , Martin H. , Sansom P.A.
Biochem. J.304:861-867(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21 AND 38-57
tissue: Monocyte.
15.

"Identification of a thioredoxin-related protein associated with plasma membranes."
Martin H. , Dean M.
Biochem. Biophys. Res. Commun.175:123-128(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-15
16.

Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 9-48; 73-81 AND 95-105;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
tissue: Fetal brain cortex.
17.

"Human thioredoxin reactivity-structure/function relationship."
Jacquot J.-P. , de Lamotte F. , Fontecav M. , Schuermann P. , Decottignies P. , Miginiac-Maslow M. , Wollman E.
Biochem. Biophys. Res. Commun.173:1375-1381(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway."
Rubartelli A. , Bajetto A. , Allavena G. , Wollman E. , Sitia R.
J. Biol. Chem.267:24161-24164(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
19.

"AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1."
Hirota K. , Matsui M. , Iwata S. , Nishiyama A. , Mori K. , Yodoi J.
Proc. Natl. Acad. Sci. U.S.A.94:3633-3638(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH APEX1;MUTAGENESIS OF CYS-32; CYS-35; CYS-62; CYS-69 AND CYS-73;SUBCELLULAR LOCATION
20.

"Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation."
Wei S.J. , Botero A. , Hirota K. , Bradbury C.M. , Markovina S. , Laszlo A. , Spitz D.R. , Goswami P.C. , Yodoi J. , Gius D.
Cancer Res.60:6688-6695(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;SUBCELLULAR LOCATION
21.

"S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1."
Yasinska I.M. , Kozhukhar A.V. , Sumbayev V.V.
Arch. Biochem. Biophys.428:198-203(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION;INTERACTION WITH MAP3K5
22.

"Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine."
Mitchell D.A. , Marletta M.A.
Nat. Chem. Biol.1:154-158(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-73;S-NITROSYLATION AT CYS-73
23.

"Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells."
Mitchell D.A. , Morton S.U. , Fernhoff N.B. , Marletta M.A.
Proc. Natl. Acad. Sci. U.S.A.104:11609-11614(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-69; GLU-70; LYS-72 AND CYS-73;S-NITROSYLATION AT CYS-73 IN RESPONSE TO NITRIC OXIDE
24.

"Abnormal proteins in primary breast cancer tissues from 25 Sudanese patients."
Ahamed M.E. , Ahmed M.E. , Eltoum A.M. , Altahir G.O. , Ahmed K.M. , Harbi S.O. , Stansalas J. , Mohamed A.O.
Eur. J. Inflamm.6:115-121(2008)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY
tissue: Mammary cancer.
25.

"Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxin."
Bernal-Bayard J. , Ramos-Morales F.
J. Biol. Chem.284:27587-27595(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH S.TYPHIMURIUM SLRP;UBIQUITINATION
26.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-3 AND LYS-39;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.

"A proton nuclear magnetic resonance assignment and secondary structure determination of recombinant human thioredoxin."
Forman-Kay J.D. , Clore G.M. , Dricoll P.C. , Wingfield P. , Richards F.M. , Gronenborn A.M.
Biochemistry28:7088-7097(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
29.

"High-resolution three-dimensional structure of reduced recombinant human thioredoxin in solution."
Forman-Kay J.D. , Clore G.M. , Wingfield P. , Gronenborn A.M.
Biochemistry30:2685-2698(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
30.

"The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin."
Qin J. , Clore G.M. , Gronenborn A.M.
Structure2:503-522(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
31.

"Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B."
Qin J. , Clore G.M. , Kennedy W.M. , Huth J.R. , Gronenborn A.M.
Structure3:289-297(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
32.

"The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal."
Qin J. , Clore G.M. , Kennedy W.P. , Kuszewski J. , Gronenborn A.M.
Structure4:613-620(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
33.

"Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer."
Weichsel A. , Gasdaska J.R. , Powis G. , Montfort W.R.
Structure4:735-751(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS)
34.

"Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --> asparagine mutant."
Andersen J.F. , Sanders D.A. , Gasdaska J.R. , Weichsel A. , Powis G. , Montfort W.R.
Biochemistry36:13979-13988(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF MUTANT ASN-60;SUBUNIT
35.

"Buried S-nitrosocysteine revealed in crystal structures of human thioredoxin."
Weichsel A. , Brailey J.L. , Montfort W.R.
Biochemistry46:1219-1227(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS);SUBUNIT;DISULFIDE BONDS;S-NITROSYLATION AT CYS-62 AND CYS-69

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