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Index > Protein center > THOP1(Gene name) > Human
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  • THOP1 (Gene name),
  • Thimet oligopeptidase (Protein name ),  THOP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    THOP1;
    Protein name:
    Thimet oligopeptidase;
    Alternative:
    MP78;Endopeptidase 24.15;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    689
    Sequence:
    50:
    MKPPAACAGD | MADAASPCSV | VNDLRWDLSA | QQIEERTREL | IEQTKRVYDQ | 
    100:
    VGTQEFEDVS | YESTLKALAD | VEVTYTVQRN | ILDFPQHVSP | SKDIRTASTE | 
    150:
    ADKKLSEFDV | EMSMREDVYQ | RIVWLQEKVQ | KDSLRPEAAR | YLERLIKLGR | 
    200:
    RNGLHLPRET | QENIKRIKKK | LSLLCIDFNK | NLNEDTTFLP | FTLQELGGLP | 
    250:
    EDFLNSLEKM | EDGKLKVTLK | YPHYFPLLKK | CHVPETRRKV | EEAFNCRCKE | 
    300:
    ENCAILKELV | TLRAQKSRLL | GFHTHADYVL | EMNMAKTSQT | VATFLDELAQ | 
    350:
    KLKPLGEQER | AVILELKRAE | CERRGLPFDG | RIRAWDMRYY | MNQVEETRYC | 
    400:
    VDQNLLKEYF | PVQVVTHGLL | GIYQELLGLA | FHHEEGASAW | HEDVRLYTAR | 
    450:
    DAASGEVVGK | FYLDLYPREG | KYGHAACFGL | QPGCLRQDGS | RQIAIAAMVA | 
    500:
    NFTKPTADAP | SLLQHDEVET | YFHEFGHVMH | QLCSQAEFAM | FSGTHVERDF | 
    550:
    VEAPSQMLEN | WVWEQEPLLR | MSRHYRTGSA | VPRELLEKLI | ESRQANTGLF | 
    600:
    NLRQIVLAKV | DQALHTQTDA | DPAEEYARLC | QEILGVPATP | GTNMPATFGH | 
    650:
    LAGGYDAQYY | GYLWSEVYSM | DMFHTRFKQE | GVLNSKVGMD | YRSCILRPGG | 
    689:
    SEDASAMLRR | FLGRDPKQDA | FLLSKGLQVG | GCEPEPQVC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    Pfam:
    SMR:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Thimet oligopeptidase
    Cat.:
    E13023h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Thimet oligopeptidase
    MSDS:
    Please sign in first.
    ELISA Kit for Human Thimet oligopeptidase
    Cat.:
    E13023r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Thimet oligopeptidase
    MSDS:
    Please sign in first.
    ELISA Kit for Human Thimet oligopeptidase
    Cat.:
    E13023m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Thimet oligopeptidase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Thimet oligopeptidase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Thimet oligopeptidase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Thimet oligopeptidase
    Cat.:
    U13023h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Thimet oligopeptidase
    Cat.:
    U13023m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Thimet oligopeptidase
    Polyclonal Antibody for Human Thimet oligopeptidase
    Polyclonal Antibody for Human Thimet oligopeptidase
    Polyclonal Antibody for Human Thimet oligopeptidase
    Polyclonal Antibody for Human Thimet oligopeptidase
    Monoclonal Antibody for Human Thimet oligopeptidase
    Monoclonal Antibody for Human Thimet oligopeptidase
    Monoclonal Antibody for Human Thimet oligopeptidase
    Monoclonal Antibody for Human Thimet oligopeptidase
    Monoclonal Antibody for Human Thimet oligopeptidase
    Protein for Human Thimet oligopeptidase
    Protein for Human Thimet oligopeptidase
    Protein for Human Thimet oligopeptidase
    Protein for Human Thimet oligopeptidase
    Protein for Human Thimet oligopeptidase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide."
      Thompson A. , Huber G. , Malherbe P.
      Biochem. Biophys. Res. Commun.213:66-73(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "cDNA cloning and gene structure of a human gene encoding a highly conserved metalloendopeptidase (EC 3.4.24.15)."
      Taylor G.R. , Otulakowski G. , Lau C.Y. , Munroe D.G.
      Submitted (1995-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    4. 4.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
      tissue: Placenta.
    6. 6.
      "Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments."
      Papastoitsis G. , Siman R. , Scott R. , Abraham C.R.
      Biochemistry33:192-199(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 67-78; 181-197 AND 199-200
      tissue: Brain.
    7. 7.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-257 AND LYS-538;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase."
      Lim E.J. , Sampath S. , Coll-Rodriguez J. , Schmidt J. , Ray K. , Rodgers D.W.
      J. Biol. Chem.282:9722-9732(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 16-688;ZINC-BINDING SITES
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