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Index > Protein center > TIMP2(Gene name) > Bovine
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  • TIMP2 (Gene name),
  • Metalloproteinase inhibitor 2 (Protein name ),  TIMP2_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TIMP2;
    Protein name:
    Metalloproteinase inhibitor 2;
    Alternative:
    Tissue inhibitor of metalloproteinases 2(TIMP-2);Collagenase inhibitor;
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.
    Function:
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    220
    Sequence:
    50:
    MGAAARSLPL | AFCLLLLGTL | LPRADACSCS | PVHPQQAFCN | ADIVIRAKAV | 
    100:
    NKKEVDSGND | IYGNPIKRIQ | YEIKQIKMFK | GPDQDIEFIY | TAPAAAVCGV | 
    150:
    SLDIGGKKEY | LIAGKAEGNG | NMHITLCDFI | VPWDTLSATQ | KKSLNHRYQM | 
    200:
    GCECKITRCP | MIPCYISSPD | ECLWMDWVTE | KNINGHQAKF | FACIKRSDGS | 
    220:
    CAWYRGAAPP | KQEFLDIEDP | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    SMR:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    E0128h
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    96T
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    ELISA Kit for Bovine Metalloproteinase inhibitor 2
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    E0128r
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    96T
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    ELISA Kit for Bovine Metalloproteinase inhibitor 2
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    E0128m
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    96T
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    ELISA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    E0128c
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    Packing:
    96T
    ELISA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    E0128d
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    96T
    ELISA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    E0128b
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    96T
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    ELISA Kit for Bovine Metalloproteinase inhibitor 2
    MSDS:
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    CLIA Kit for Bovine Metalloproteinase inhibitor 2
    MSDS:
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    CLIA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    U0128b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    U0128h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    U0128m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    U0128r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    U0128d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Bovine Metalloproteinase inhibitor 2
    Cat.:
    U0128c
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    Packing:
    96T
    Polyclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Polyclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Polyclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Polyclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Polyclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Cat.:
    P0128Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Cat.:
    P0128Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Cat.:
    P0128Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Monoclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Monoclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Monoclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Monoclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Monoclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Monoclonal Antibody for Bovine Metalloproteinase inhibitor 2
    Protein for Bovine Metalloproteinase inhibitor 2
    Protein for Bovine Metalloproteinase inhibitor 2
    Protein for Bovine Metalloproteinase inhibitor 2
    Protein for Bovine Metalloproteinase inhibitor 2
    Protein for Bovine Metalloproteinase inhibitor 2
    Protein for Bovine Metalloproteinase inhibitor 2
    Protein for Bovine Metalloproteinase inhibitor 2
    Cat.:
    R0128h
    Price:
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    Packing:
    1mg
    Purity:
    >90%

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    References
    1. 1.
      "cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases."
      Boone T.C. , Johnson M.J. , de Clerck Y.A. , Langley K.E.
      Proc. Natl. Acad. Sci. U.S.A.87:2800-2804(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2005-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Crossbred X Angus.
      tissue: Liver.
    3. 3.
      "Involvement of fibroblasts and muscle cells in the expression of an extracellular proteolytic cascade in bovine skeletal muscle."
      Balcerzak D. , Querengesser L. , Dixon W.T. , Baracos V.E.
      Submitted (1999-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-218
      tissue: Skeletal muscle.
    4. 4.
      "Purification and partial amino acid sequence of a bovine cartilage-derived collagenase inhibitor."
      Murray J.B. , Allison K. , Sudhalter J. , Langer R.
      J. Biol. Chem.261:4154-4159(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-71
      tissue: Cartilage.
    5. 5.
      "Purification and characterization of two related but distinct metalloproteinase inhibitors secreted by bovine aortic endothelial cells."
      de Clerck Y.A. , Yean T.D. , Ratzkin B.J. , Lu H.S. , Langley K.E.
      J. Biol. Chem.264:17445-17453(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-71
    6. 6.
      "Characterization of the functional domain of tissue inhibitor of metalloproteinases-2 (TIMP-2)."
      De Clerck Y.A. , Yean T.D. , Lee Y. , Tomich J.M. , Langley K.E.
      Biochem. J.289:65-69(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-71
    7. 7.
      "Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor."
      Fernandez-Catalan C. , Bode W. , Huber R. , Turk D. , Calvete J.J. , Lichte A. , Tschesche H. , Maskos K.
      EMBO J.17:5238-5248(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 27-210 IN COMPLEX WITH MMP-1;COFACTOR
    8. 8.
      "Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2."
      Maskos K. , Lang R. , Tschesche H. , Bode W.
      J. Mol. Biol.366:1222-1231(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 28-206 IN COMPLEX WITH MMP-13;DISULFIDE;COFACTOR
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