"Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction."
Fitzgerald K.A. , Palsson-McDermott E.M. , Bowie A.G. , Jefferies C.A. , Mansell A.S. , Brady G. , Brint E. , Dunne A. , Gray P. , Harte M.T. , McMurray D. , Smith D.E. , Sims J.E. , Bird T.A. , O'Neill L.A.J.
Nature413:78-83(2001) [PubMed] [Europe PMC] [Abstract]

"TIRAP: an adapter molecule in the Toll signaling pathway."
Horng T. , Barton G.M. , Medzhitov R.
Nat. Immunol.2:835-841(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization and structural analysis of TIR domain-containing adaptor protein Wyatt."
Kirk P.B. , Pereira J.P. , Bazan J.F.
Submitted (2001-08) to the EMBL/GenBank/DDBJ databases

"Two isoforms of MAL, generated by alternative splicing, are found in humans but not mice."
Hardy M.P. , O'Neill L.A.J.
Submitted (2004-03) to the EMBL/GenBank/DDBJ databases

"Natural selection in the TLR-related genes in the course of primate evolution."
Nakajima T. , Ohtani H. , Satta Y. , Uno Y. , Akari H. , Ishida T. , Kimura A.
Immunogenetics60:727-735(2008) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , Yamamoto J. , Saito K. , Kawai Y. , Isono Y. , Nakamura Y. , Nagahari K. , Murakami K. , Yasuda T. , Iwayanagi T. , Wagatsuma M. , Shiratori A. , Sudo H. , Hosoiri T. , Kaku Y. , Kodaira H. , Kondo H. , Sugawara M. , Takahashi M. , Kanda K. , Yokoi T. , Furuya T. , Kikkawa E. , Omura Y. , Abe K. , Kamihara K. , Katsuta N. , Sato K. , Tanikawa M. , Yamazaki M. , Ninomiya K. , Ishibashi T. , Yamashita H. , Murakawa K. , Fujimori K. , Tanai H. , Kimata M. , Watanabe M. , Hiraoka S. , Chiba Y. , Ishida S. , Ono Y. , Takiguchi S. , Watanabe S. , Yosida M. , Hotuta T. , Kusano J. , Kanehori K. , Takahashi-Fujii A. , Hara H. , Tanase T.-O. , Nomura Y. , Togiya S. , Komai F. , Hara R. , Takeuchi K. , Arita M. , Imose N. , Musashino K. , Yuuki H. , Oshima A. , Sasaki N. , Aotsuka S. , Yoshikawa Y. , Matsunawa H. , Ichihara T. , Shiohata N. , Sano S. , Moriya S. , Momiyama H. , Satoh N. , Takami S. , Terashima Y. , Suzuki O. , Nakagawa S. , Senoh A. , Mizoguchi H. , Goto Y. , Shimizu F. , Wakebe H. , Hishigaki H. , Watanabe T. , Sugiyama A. , Takemoto M. , Kawakami B. , Yamazaki M. , Watanabe K. , Kumagai A. , Itakura S. , Fukuzumi Y. , Fujimori Y. , Komiyama M. , Tashiro H. , Tanigami A. , Fujiwara T. , Ono T. , Yamada K. , Fujii Y. , Ozaki K. , Hirao M. , Ohmori Y. , Kawabata A. , Hikiji T. , Kobatake N. , Inagaki H. , Ikema Y. , Okamoto S. , Okitani R. , Kawakami T. , Noguchi S. , Itoh T. , Shigeta K. , Senba T. , Matsumura K. , Nakajima Y. , Mizuno T. , Morinaga M. , Sasaki M. , Togashi T. , Oyama M. , Hata H. , Watanabe M. , Komatsu T. , Mizushima-Sugano J. , Satoh T. , Shirai Y. , Takahashi Y. , Nakagawa K. , Okumura K. , Nagase T. , Nomura N. , Kikuchi H. , Masuho Y. , Yamashita R. , Nakai K. , Yada T. , Nakamura Y. , Ohara O. , Isogai T. , Sugano S. more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

SeattleSNPs variation discovery resource
Submitted (2003-04) to the EMBL/GenBank/DDBJ databases

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , Jaffe D.B. , LaButti K. , Nicol R. , Park H.-S. , Seaman C. , Sougnez C. , Yang X. , Zimmer A.R. , Zody M.C. , Birren B.W. , Nusbaum C. , Fujiyama A. , Hattori M. , Rogers J. , Lander E.S. , Sakaki Y. more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , Yooseph S. , Lu F. , Nusskern D.R. , Shue B.C. , Zheng X.H. , Zhong F. , Delcher A.L. , Huson D.H. , Kravitz S.A. , Mouchard L. , Reinert K. , Remington K.A. , Clark A.G. , Waterman M.S. , Eichler E.E. , Adams M.D. , Hunkapiller M.W. , Myers E.W. , Venter J.C. more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling."
Sato S. , Sugiyama M. , Yamamoto M. , Watanabe Y. , Kawai T. , Takeda K. , Akira S.
J. Immunol.171:4304-4310(2003) [PubMed] [Europe PMC] [Abstract]

"Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation."
Mansell A. , Smith R. , Doyle S.L. , Gray P. , Fenner J.E. , Crack P.J. , Nicholson S.E. , Hilton D.J. , O'Neill L.A. , Hertzog P.J.
Nat. Immunol.7:148-155(2006) [PubMed] [Europe PMC] [Abstract]

"Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways."
Semaan N. , Alsaleh G. , Gottenberg J.E. , Wachsmann D. , Sibilia J.
J. Immunol.180:3485-3491(2008) [PubMed] [Europe PMC] [Abstract]

"A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling."
Nagpal K. , Plantinga T.S. , Wong J. , Monks B.G. , Gay N.J. , Netea M.G. , Fitzgerald K.A. , Golenbock D.T.
J. Biol. Chem.284:25742-25748(2009) [PubMed] [Europe PMC] [Abstract]

"AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling."
Wan T. , Liu T. , Zhang H. , Tang S. , Min W.
J. Biol. Chem.285:3750-3757(2010) [PubMed] [Europe PMC] [Abstract]

"IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)."
Dunne A. , Carpenter S. , Brikos C. , Gray P. , Strelow A. , Wesche H. , Morrice N. , O'Neill L.A.
J. Biol. Chem.285:18276-18282(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection."
Valkov E. , Stamp A. , Dimaio F. , Baker D. , Verstak B. , Roversi P. , Kellie S. , Sweet M.J. , Mansell A. , Gay N.J. , Martin J.L. , Kobe B.
Proc. Natl. Acad. Sci. U.S.A.108:14879-14884(2011) [PubMed] [Europe PMC] [Abstract]

"A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis."
Khor C.C. , Chapman S.J. , Vannberg F.O. , Dunne A. , Murphy C. , Ling E.Y. , Frodsham A.J. , Walley A.J. , Kyrieleis O. , Khan A. , Aucan C. , Segal S. , Moore C.E. , Knox K. , Campbell S.J. , Lienhardt C. , Scott A. , Aaby P. , Sow O.Y. , Grignani R.T. , Sillah J. , Sirugo G. , Peshu N. , Williams T.N. , Maitland K. , Davies R.J.O. , Kwiatkowski D.P. , Day N.P. , Yala D. , Crook D.W. , Marsh K. , Berkley J.A. , O'Neill L.A.J. , Hill A.V.S. more...
Nat. Genet.39:523-528(2007) [PubMed] [Europe PMC] [Abstract]

"Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy."
Hamann L. , Kumpf O. , Schuring R.P. , Alpsoy E. , Bedu-Addo G. , Bienzle U. , Oskam L. , Mockenhaupt F.P. , Schumann R.R.
BMC Med. Genet.10:65-65(2009) [PubMed] [Europe PMC] [Abstract]