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Index > Protein center > TIRAP(Gene name) > Human
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  • TIRAP (Gene name),
  • Toll/interleukin-1 receptor domain-containing adapter protein (Protein name ),  TIRAP_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    TIRAP(MAL);
    Protein name:
    Toll/interleukin-1 receptor domain-containing adapter protein(TIR domain-containing adapter protein);
    Alternative:
    MyD88 adapter-like protein(MyD88-2);Adaptor protein Wyatt;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to BMX, PKR and TBK1. Does not interact with IRAK1, nor TLR9.
    Function:
    Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    221
    Sequence:
    50:
    MASSTSLPAP | GSRPKKPLGK | MADWFRQTLL | KKPKKRPNSP | ESTSSDASQP | 
    100:
    TSQDSPLPPS | LSSVTSPSLP | PTHASDSGSS | RWSKDYDVCV | CHSEEDLVAA | 
    150:
    QDLVSYLEGS | TASLRCFLQL | RDATPGGAIV | SELCQALSSS | HCRVLLITPG | 
    200:
    FLQDPWCKYQ | MLQALTEAPG | AEGCTIPLLS | GLSRAAYPPE | LRFMYYVDGR | 
    221:
    GPDGGFRQVK | EAVMRYLQTL | S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    SMR:
    String:
    Pfam:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human TIR domain-containing adapter protein
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    E4819h
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    96T
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    ELISA Kit for Human TIR domain-containing adapter protein
    Cat.:
    E4819m
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    Packing:
    96T
    CLIA Kit for Human TIR domain-containing adapter protein
    Cat.:
    U4819m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human TIR domain-containing adapter protein
    Cat.:
    U4819h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human TIR domain-containing adapter protein
    Cat.:
    P4819Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TIR domain-containing adapter protein
    Cat.:
    P4819Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human TIR domain-containing adapter protein
    Monoclonal Antibody for Human TIR domain-containing adapter protein
    Protein for Human TIR domain-containing adapter protein
    Protein for Human TIR domain-containing adapter protein

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);MUTAGENESIS OF PRO-125;VARIANT ASN-55
      tissue: Dendritic cell.
    2. 2.
      "TIRAP: an adapter molecule in the Toll signaling pathway."
      Horng T. , Barton G.M. , Medzhitov R.
      Nat. Immunol.2:835-841(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);MUTAGENESIS OF PRO-125;INTERACTION WITH EIF2AK2
    3. 3.
      "Characterization and structural analysis of TIR domain-containing adaptor protein Wyatt."
      Kirk P.B. , Pereira J.P. , Bazan J.F.
      Submitted (2001-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Two isoforms of MAL, generated by alternative splicing, are found in humans but not mice."
      Hardy M.P. , O'Neill L.A.J.
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    5. 5.
      "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T. , Ohtani H. , Satta Y. , Uno Y. , Akari H. , Ishida T. , Kimura A.
      Immunogenetics60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ASN-55
      tissue: Brain.
      tissue: Trachea.
    7. 7.
      SeattleSNPs variation discovery resource
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-9; TRP-13; ASN-96 AND LEU-180
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Blood.
    11. 11.
      "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling."
      Sato S. , Sugiyama M. , Yamamoto M. , Watanabe Y. , Kawai T. , Takeda K. , Akira S.
      J. Immunol.171:4304-4310(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBK1
    12. 12.
      "Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation."
      Mansell A. , Smith R. , Doyle S.L. , Gray P. , Fenner J.E. , Crack P.J. , Nicholson S.E. , Hilton D.J. , O'Neill L.A. , Hertzog P.J.
      Nat. Immunol.7:148-155(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY BTK;UBIQUITINATION
    13. 13.
      "Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways."
      Semaan N. , Alsaleh G. , Gottenberg J.E. , Wachsmann D. , Sibilia J.
      J. Immunol.180:3485-3491(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BMX
    14. 14.
      "A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling."
      Nagpal K. , Plantinga T.S. , Wong J. , Monks B.G. , Gay N.J. , Netea M.G. , Fitzgerald K.A. , Golenbock D.T.
      J. Biol. Chem.284:25742-25748(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MYD88;VARIANT ASN-96;CHARACTERIZATION OF VARIANTS PRO-9; TRP-13; ASN-96; LEU-180 AND ILE-197
    15. 15.
      "AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling."
      Wan T. , Liu T. , Zhang H. , Tang S. , Min W.
      J. Biol. Chem.285:3750-3757(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYD88;SUBCELLULAR LOCATION
    16. 16.
      "IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)."
      Dunne A. , Carpenter S. , Brikos C. , Gray P. , Strelow A. , Wesche H. , Morrice N. , O'Neill L.A.
      J. Biol. Chem.285:18276-18282(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY IRAK1 AND IRAK4
    17. 17.
      "Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection."
      Valkov E. , Stamp A. , Dimaio F. , Baker D. , Verstak B. , Roversi P. , Kellie S. , Sweet M.J. , Mansell A. , Gay N.J. , Martin J.L. , Kobe B.
      Proc. Natl. Acad. Sci. U.S.A.108:14879-14884(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.01 ANGSTROMS) OF 79-221;SUBUNIT;DISULFIDE BONDS
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-180;POSSIBLE INVOLVEMENT IN PROTECTION AGAINST INVASIVE PNEUMOCOCCAL DISEASE; BACTEREMIA; MALARIA AND TUBERCULOSIS
    19. 19.
      "Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy."
      Hamann L. , Kumpf O. , Schuring R.P. , Alpsoy E. , Bedu-Addo G. , Bienzle U. , Oskam L. , Mockenhaupt F.P. , Schumann R.R.
      BMC Med. Genet.10:65-65(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-180
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