TNFSF11 ELISA Kit for Human(Homo sapiens) | EIAab.comTNFSF11 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > TNFSF11(Gene name) > Human

TNFSF11 (Gene name),

Tumor necrosis factor ligand superfamily member 11 (Protein name ), TNF11_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (4)

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Gene name:

TNFSF11(OPGL;RANKL;TRANCE);

Protein name:

Tumor necrosis factor ligand superfamily member 11;

Alternative:

Osteoprotegerin ligand(OPGL);Osteoclast differentiation factor(ODF);TNF-related activation-induced cytokine(TRANCE);Receptor activator of nuclear factor kappa-B ligand(RANKL);

CD:

CD254;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer.

Function:

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subcellular Location:

Tumor necrosis factor ligand superfamily member 11, soluble form Secreted

Protein Attributes:

Sequence length:

317

Sequence:

50:

100:

150:

200:

250:

300:

317:

PDQDATYFGA | FKVRDID

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00229

UniGene:

Hs.333791

STRING:

9606.ENSP00000239849

SMR:

O14788

MIM:

259710

KEGG:

hsa:8600

String:

O14788

Uniprot:

O14788

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ELISA Kit for Human Tumor necrosis factor ligand superfamily member 11

Cat.:

E0855r

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96T

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ELISA Kit for Human Tumor necrosis factor ligand superfamily member 11

Cat.:

E0855m

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96T

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ELISA Kit for Human Tumor necrosis factor ligand superfamily member 11

Cat.:

E0855h

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CLIA Kit for Human Tumor necrosis factor ligand superfamily member 11

Cat.:

U0855h

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96T

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CLIA Kit for Human Tumor necrosis factor ligand superfamily member 11

Cat.:

U0855m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Tumor necrosis factor ligand superfamily member 11

Cat.:

U0855r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11

Cat.:

P0855Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11

Cat.:

P0855Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11

Cat.:

P0855Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11

Protein for Human Tumor necrosis factor ligand superfamily member 11

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic..."

Victoria Clérigues, Maria Isabel Guillén, Miguel Angel Castejón, Francisco Gomard, Vicente Mirabete, Maria José Alcaraz

From:Biochemical Pharmacology

[2].

"The Inhibitory Effect of Roasted Licorice Extract on Human Metastatic Breast Cancer Cell-Induced Bone Destruction"

Sun Kyoung Lee, Kwang-Kyun Park, Jung Han Yoon Park, Soon Sung Lim, Won-Yoon Chung

From:PhytotherapyReseach

[3].

"The Inhibitory Effect of Roasted Licorice Extract on Human Metastatic Breast Cancer Cell‐Induced Bone Destruction"

SK Lee, KK Park, JHY Park, et al.

From:Phytotherapy Research

[4].

"Isoliquiritigenin inhibits metastatic breast cancer cell-induced receptor activator of nuclear factor kappa-B ligand/osteoprotegerin ratio in human..."

Lee S K, Park K K, Kim K R, et al.

From:Journal of cancer prevention

References

1.

"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function."
Anderson D.M. , Maraskovsky E. , Billingsley W.L. , Dougall W.C. , Tometsko M.E. , Roux E.R. , Teepe M.C. , DuBose R.F. , Cosman D. , Galibert L.
Nature390:175-179(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Bone marrow.
tissue: Peripheral blood.
2.

"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation."
Lacey D.L. , Timms E. , Tan H.-L. , Kelley M.J. , Dunstan C.R. , Burgess T. , Elliott R. , Colombero A. , Elliott G. , Scully S. , Hsu H. , Sullivan J. , Hawkins N. , Davy E. , Capparelli C. , Eli A. , Qian Y.-X. , Kaufman S. , more...
Cell93:165-176(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Lymph node.
3.

"Determination of human RANKL isoforms."
Ikeda T. , Kuroyama H. , Hirokawa K.
Submitted (2001-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
4.

"Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation."
Nagai M. , Kyakumoto S. , Sato N.
Biochem. Biophys. Res. Commun.269:532-536(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Tongue.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
6.

"TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells."
Wong B.R. , Rho J. , Arron J. , Robinson E. , Orlinick J. , Chao M. , Kalachikov S. , Cayani E. , Bartlett F.S. III , Frankel W.N. , Lee S.Y. , Choi Y.
J. Biol. Chem.272:25190-25194(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-317
tissue: Thymocyte.
7.

"Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin."
Luan X. , Lu Q. , Jiang Y. , Zhang S. , Wang Q. , Yuan H. , Zhao W. , Wang J. , Wang X.
J. Immunol.189:245-252(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 162-317 IN COMPLEX WITH TNFRSF11B;FUNCTION;MUTAGENESIS OF ARG-223 AND LYS-257;INTERACTION WITH TNFRSF11B
8.

"Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL."
Sobacchi C. , Frattini A. , Guerrini M.M. , Abinun M. , Pangrazio A. , Susani L. , Bredius R. , Mancini G. , Cant A. , Bishop N. , Grabowski P. , Del Fattore A. , Messina C. , Errigo G. , Coxon F.P. , Scott D.I. , Teti A. , Rogers M.J. , more...
Nat. Genet.39:960-962(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OPTB2 LYS-199

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