Gene name:
TRPC4AP (C20orf188;TRRP4AP) ;
Protein name:
Short transient receptor potential channel 4-associated protein (Trp4-associated protein;Trpc4-associated protein) ;
Alternative:
TNF-receptor ubiquitous scaffolding/signaling protein (Protein TRUSS) ;Protein TAP1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG. Interacts with TRPC1, TRPC4 and TRPC5 (By similarity). Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts with MYC.
Function:
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
Subcellular Location:
N/A
Protein Attributes:
50:
MAAAPVAAGS | GAGRGRRSAA | TVAAWGGWGG | RPRPGNILLQ | LRQGQLTGRG |
100:
LVRAVQFTET | FLTERDKQSK | WSGIPQLLLK | LHTTSHLHSD | FVECQNILKE |
150:
ISPLLSMEAM | AFVTEERKLT | QETTYPNTYI | FDLFGGVDLL | VEILMRPTIS |
200:
IRGQKLKISD | EMSKDCLSIL | YNTCVCTEGV | TKRLAEKNDF | VIFLFTLMTS |
250:
KKTFLQTATL | IEDILGVKKE | MIRLDEVPNL | SSLVSNFDQQ | QLANFCRILA |
300:
VTISEMDTGN | DDKHTLLAKN | AQQKKSLSLG | PSAAEINQAA | LLSIPGFVER |
350:
LCKLATRKVS | ESTGTASFLQ | ELEEWYTWLD | NALVLDALMR | VANEESEHNQ |
400:
ASIVFPPPGA | SEENGLPHTS | ARTQLPQSMK | IMHEIMYKLE | VLYVLCVLLM |
450:
GRQRNQVHRM | IAEFKLIPGL | NNLFDKLIWR | KHSASALVLH | GHNQNCDCSP |
500:
DITLKIQFLR | LLQSFSDHHE | NKYLLLNNQE | LNELSAISLK | ANIPEVEAVL |
550:
NTDRSLVCDG | KRGLLTRLLQ | VMKKEPAESS | FRFWQARAVE | SFLRGTTSYA |
600:
DQMFLLKRGL | LEHILYCIVD | SECKSRDVLQ | SYFDLLGELM | KFNVDAFKRF |
650:
NKYINTDAKF | QVFLKQINSS | LVDSNMLVRC | VTLSLDRFEN | QVDMKVAEVL |
700:
SECRLLAYIS | QVPTQMSFLF | RLINIIHVQT | LTQENVSCLN | TSLVILMLAR |
750:
RKERLPLYLR | LLQRMEHSKK | YPGFLLNNFH | NLLRFWQQHY | LHKDKDSTCL |
797:
ENSSCISFSY | WKETVSILLN | PDRQSPSALV | SYIEEPYMDI | DRDFTEE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Trp4-associated protein
ELISA Kit for Human Trp4-associated protein
CLIA Kit for Human Trp4-associated protein
CLIA Kit for Human Trp4-associated protein
Polyclonal Antibody for Human Trp4-associated protein
Polyclonal Antibody for Human Trp4-associated protein
Monoclonal Antibody for Human Trp4-associated protein
Monoclonal Antibody for Human Trp4-associated protein
Protein for Human Trp4-associated protein
Protein for Human Trp4-associated protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Cervix .
tissue :
Muscle .
tissue :
Prostate .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-797 (ISOFORM 1)
tissue :
Mammary cancer .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN A DCX (DDB1-CUL4-X-BOX) E3 UBIQUITIN-PROTEIN LIGASE COMPLEX;INTERACTION WITH MYC
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DDB1
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Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]