TNFRSF10A ELISA Kit for Human(Homo sapiens) | EIAab.comTNFRSF10A ELISA Kit for Human(Homo sapiens)

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TNFRSF10A (Gene name),

Tumor necrosis factor receptor superfamily member 10A (Protein name ), TR10A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TNFRSF10A(APO2;DR4;TRAILR1);

Protein name:

Tumor necrosis factor receptor superfamily member 10A;

Alternative:

TNF-related apoptosis-inducing ligand receptor 1(TRAIL receptor 1;TRAIL-R1);Death receptor 4;

CD:

CD261;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Can interact with TRADD and RIPK1. Interacts with ARAP1.

Function:

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

468

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

468:

SGKFIYLEDG | TGSAVSLE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:8797

SMR:

O00220

Pfam:

PF00531

String:

O00220

MIM:

603611

UniGene:

Hs.213467

STRING:

9606.ENSP00000221132

Uniprot:

O00220

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ELISA Kit for Human Tumor necrosis factor receptor superfamily member 10A

Cat.:

E8715h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Tumor necrosis factor receptor superfamily member 10A

Cat.:

U8715h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 10A

Cat.:

P8715Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 10A

Protein for Human Tumor necrosis factor receptor superfamily member 10A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.8%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤6.9%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of TR10A into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	91	85-100
Plasma	93	86-102

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of TR10A and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	83-100%	85-99%	81-103%	88-95%
EDTA plasma(n=5)	89-99%	88-98%	83-101%	84-100%
heparin plasma(n=5)	86-101%	90-97%	85-102%	90-98%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The receptor for the cytotoxic ligand TRAIL."
Pan G. , O'Rourke K. , Chinnaiyan A.M. , Gentz R. , Ebner R. , Ni J. , Dixit V.M.
Science276:111-113(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ARG-141; THR-209 AND LYS-441
2.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LYS-441
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ARG-141; THR-209 AND LYS-441
tissue: Tongue.
4.

Livingston R.J. , Shaffer T. , McFarland I. , Nguyen C.P. , Stanaway I.B. , Rajkumar N. , Johnson E.J. , da Ponte S.H. , Willa H. , Ahearn M.O. , Bertucci C. , Acklestad J. , Carroll A. , Swanson J. , Gildersleeve H.I. , Nickerson D.A.
Submitted (2006-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LYS-441
5.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LYS-441
tissue: Ovary.
7.

"Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway."
Chaudhary P.M. , Eby M. , Jasmin A. , Bookwalter A. , Murray J. , Hood L.
Immunity7:821-830(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane."
Simova S. , Klima M. , Cermak L. , Sourkova V. , Andera L.
Apoptosis13:423-436(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARAP1
10.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-463 AND SER-466;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses."
Smith W. , Tomasec P. , Aicheler R. , Loewendorf A. , Nemcovicova I. , Wang E.C. , Stanton R.J. , Macauley M. , Norris P. , Willen L. , Ruckova E. , Nomoto A. , Schneider P. , Hahn G. , Zajonc D.M. , Ware C.F. , Wilkinson G.W. , Benedict C.A.
Cell Host Microbe13:324-335(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN CYTOMEGALOVIRUS PROTEIN UL141

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