THBD ELISA Kit for Human(Homo sapiens) | EIAab.comTHBD ELISA Kit for Human(Homo sapiens)

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Index > Protein center > THBD(Gene name) > Human

THBD (Gene name),

Thrombomodulin (Protein name ), TRBM_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

THBD(THRM);

Protein name:

Thrombomodulin(TM);

Alternative:

Fetomodulin;

CD:

CD141;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

575

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

575:

EYKCAAPSKE | VVLQHVRTER | TPQRL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:7056

SMR:

P07204

Pfam:

PF07645

UniGene:

Hs.2030

MIM:

188040

STRING:

9606.ENSP00000366307

String:

P07204

Uniprot:

P07204

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ELISA Kit for Human TM

Cat.:

E0529m

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MSDS:

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Packing:

96T

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ELISA Kit for Human TM

Cat.:

E0529d

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Packing:

96T

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ELISA Kit for Human TM

Cat.:

E0529b

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96T

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ELISA Kit for Human TM

Cat.:

E0529h

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96T

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ELISA Kit for Human TM

Cat.:

E0529r

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MSDS:

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Packing:

96T

CLIA Kit for Human TM

Cat.:

U0529b

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TM

Cat.:

U0529m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TM

Cat.:

U0529h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human TM

Cat.:

U0529r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TM

Cat.:

U0529d

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human TM

Cat.:

P0529Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TM

Cat.:

P0529Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TM

Cat.:

P0529Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human TM

Protein for Human TM

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation."
Suzuki K. , Kusumoto H. , Deyashiki Y. , Nishioka J. , Maruyama I. , Zushi M. , Kawahara S. , Honda G. , Yamamoto S. , Horiguchi S.
EMBO J.6:1891-1897(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 19-43
2.

"Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene."
Wen D. , Dittman W.A. , Ye R.D. , Deaven L.L. , Majerus P.W. , Sadler J.E.
Biochemistry26:4350-4357(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
3.

"Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control."
Jackman R.W. , Beeler D.L. , Fritze L. , Soff G. , Rosenberg R.D.
Proc. Natl. Acad. Sci. U.S.A.84:6425-6429(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C."
Shirai T. , Shiojiri S. , Ito H. , Yamamoto S. , Kusumoto H. , Deyashiki Y. , Maruyama I. , Suzuki K.
J. Biochem.103:281-285(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

SeattleSNPs variation discovery resource
Submitted (2002-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-473
6.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-473
tissue: Brain.
tissue: Lung.
8.

"Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine 474."
Gerlitz B. , Hassell T. , Vlahos C.J. , Parkinson J.F. , Bang N.U. , Grinnell B.W.
Biochem. J.295:131-140(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-492;MUTAGENESIS
9.

"Urinary thrombomodulin, its isolation and characterization."
Yamamoto S. , Mizoguchi T. , Tamaki T. , Ohkuchi M. , Kimura S. , Aoki N.
J. Biochem.113:433-440(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HYDROXYLATION AT ASN-342
10.

"The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulin."
Adler M. , Seto M.H. , Nitecki D.E. , Lin J.H. , Light D.R. , Morser J.
J. Biol. Chem.270:23366-23372(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 389-407
11.

"Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin."
Meininger D.P. , Hunter M.J. , Komives E.A.
Protein Sci.4:1683-1695(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 364-407
12.

"Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects."
Srinivasan J. , Hu S. , Hrabal R. , Zhu Y. , Komives E.A. , Ni F.
Biochemistry33:13553-13560(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 427-444
13.

"Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin."
Hrabal R. , Komives E.A. , Ni F.
Protein Sci.5:195-203(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 427-444
14.

"Structure of the fifth EGF-like domain of thrombomodulin: an EGF-like domain with a novel disulfide-bonding pattern."
Sampoli Benitez B.A. , Hunter M.J. , Meininger D.P. , Komives E.A.
J. Mol. Biol.273:913-926(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 405-444
15.

"The first mutation identified in the thrombomodulin gene in a 45-year-old man presenting with thromboembolic disease."
Oehlin A.-K. , Marlar R.A.
Blood85:330-336(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH12 TYR-486
16.

"Thrombomodulin gene variations and thromboembolic disease."
Oehlin A.-K. , Norlund L. , Marlar R.A.
Thromb. Haemost.78:396-400(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH12 TYR-486;VARIANTS THR-43; ALA-79; SER-495 AND LEU-501
17.

"A common thrombomodulin amino acid dimorphism is associated with myocardial infarction."
Norlund L. , Holm J. , Zoller B. , Oehlin A.-K.
Thromb. Haemost.77:248-251(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-473
18.

"A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men."
Doggen C.J.M. , Kunz G. , Rosendaal F.R. , Lane D.A. , Vos H.L. , Stubbs P.J. , Manger Cats V. , Ireland H.
Thromb. Haemost.80:743-748(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-43
19.

"Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease."
Wu K.K. , Aleksic N. , Ahn C. , Boerwinkle E. , Folsom A.R. , Juneja H.
Circulation103:1386-1389(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-473
20.

"Mutations in the thrombomodulin gene are rare in patients with severe thrombophilia."
Faioni E.M. , Franchi F. , Castaman G. , Biguzzi E. , Rodeghiero F.
Br. J. Haematol.118:595-599(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH12 TYR-486;VARIANT VAL-473
21.

"Thrombomodulin mutations in atypical hemolytic-uremic syndrome."
Delvaeye M. , Noris M. , De Vriese A. , Esmon C.T. , Esmon N.L. , Ferrell G. , Del-Favero J. , Plaisance S. , Claes B. , Lambrechts D. , Zoja C. , Remuzzi G. , Conway E.M.
N. Engl. J. Med.361:345-357(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS6 THR-43; GLY-53; LEU-81; TYR-486; SER-495 AND LEU-501;CHARACTERIZATION OF VARIANTS AHUS6 THR-43; GLY-53; LEU-81; TYR-486; SER-495 AND LEU-501;VARIANT VAL-473
22.

"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
Maga T.K. , Nishimura C.J. , Weaver A.E. , Frees K.L. , Smith R.J.H.
Hum. Mutat.31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS6 GLU-34 AND GLY-236

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