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Index > Protein center > TARBP2(Gene name) > Human
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  • TARBP2 (Gene name),
  • RISC-loading complex subunit TARBP2 (Protein name ),  TRBP2_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    TARBP2(TRBP);
    Protein name:
    RISC-loading complex subunit TARBP2;
    Alternative:
    Trans-activation-responsive RNA-binding protein;TAR RNA-binding protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9, EIF6, MOV10 and PRKRA. Associates with the 60S ribosome.
    Function:
    Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.
    Subcellular Location:
    Cytoplasm Cytoplasm perinuclear region Nucleus
    Protein Attributes:
    Sequence length:
    366
    Sequence:
    50:
    MSEEEQGSGT | TTGCGLPSIE | QMLAANPGKT | PISLLQEYGT | RIGKTPVYDL | 
    100:
    LKAEGQAHQP | NFTFRVTVGD | TSCTGQGPSK | KAAKHKAAEV | ALKHLKGGSM | 
    150:
    LEPALEDSSS | FSPLDSSLPE | DIPVFTAAAA | ATPVPSVVLT | RSPPMELQPP | 
    200:
    VSPQQSECNP | VGALQELVVQ | KGWRLPEYTV | TQESGPAHRK | EFTMTCRVER | 
    250:
    FIEIGSGTSK | KLAKRNAAAK | MLLRVHTVPL | DARDGNEVEP | DDDHFSIGVG | 
    300:
    SRLDGLRNRG | PGCTWDSLRN | SVGEKILSLR | SCSLGSLGAL | GPACCRVLSE | 
    350:
    LSEEQAFHVS | YLDIEELSLS | GLCQCLVELS | TQPATVCHGS | ATTREAARGE | 
    366:
    AARRALQYLK | IMAGSK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    MIM:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
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    ELISA Kit for Human RISC-loading complex subunit TARBP2
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    ELISA Kit for Human RISC-loading complex subunit TARBP2
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    ELISA Kit for Human RISC-loading complex subunit TARBP2
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    CLIA Kit for Human RISC-loading complex subunit TARBP2
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    CLIA Kit for Human RISC-loading complex subunit TARBP2
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    CLIA Kit for Human RISC-loading complex subunit TARBP2
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    U3425h
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    CLIA Kit for Human RISC-loading complex subunit TARBP2
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    Packing:
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    Polyclonal Antibody for Human RISC-loading complex subunit TARBP2
    Polyclonal Antibody for Human RISC-loading complex subunit TARBP2
    Polyclonal Antibody for Human RISC-loading complex subunit TARBP2
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    P3425Rb-h
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    Polyclonal Antibody for Human RISC-loading complex subunit TARBP2
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    P3425Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human RISC-loading complex subunit TARBP2
    Monoclonal Antibody for Human RISC-loading complex subunit TARBP2
    Monoclonal Antibody for Human RISC-loading complex subunit TARBP2
    Monoclonal Antibody for Human RISC-loading complex subunit TARBP2
    Protein for Human RISC-loading complex subunit TARBP2
    Protein for Human RISC-loading complex subunit TARBP2
    Protein for Human RISC-loading complex subunit TARBP2
    Protein for Human RISC-loading complex subunit TARBP2

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    References
    1. 1.
      "Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR."
      Gatignol A. , Buckler-White A.J. , Berkhout B. , Jeang K.T.
      Science251:1597-1600(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANT PHE-251
    2. 2.
      Gatignol A. , Duarte M.
      Submitted (2000-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)."
      Kozak C.A. , Gatignol A. , Graham K. , Jeang K.T. , McBride O.W.
      Genomics25:66-72(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT PHE-251
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
    7. 7.
      "Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line."
      Bannwarth S. , Talakoub L. , Letourneur F. , Duarte M. , Purcell D.F. , Hiscott J. , Gatignol A.
      J. Biol. Chem.276:48803-48813(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74;ALTERNATIVE PROMOTER USAGE
    8. 8.
      "Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen."
      Gatignol A. , Buckler C. , Jeang K.T.
      Mol. Cell. Biol.13:2193-2202(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF RNA-BINDING
    9. 9.
      "Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression."
      Daher A. , Longuet M. , Dorin D. , Bois F. , Segeral E. , Bannwarth S. , Battisti P.-L. , Purcell D.F. , Benarous R. , Vaquero C. , Meurs E.F. , Gatignol A.
      J. Biol. Chem.276:33899-33905(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SELF-ASSOCIATION;INTERACTION WITH EIF2AK2
    10. 10.
      "The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR."
      Dorin D. , Bonnet M.C. , Bannwarth S. , Gatignol A. , Meurs E.F. , Vaquero C.
      J. Biol. Chem.278:4440-4448(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing."
      Gregory R.I. , Chendrimada T.P. , Cooch N. , Shiekhattar R.
      Cell123:631-640(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DICER1 AND AGO2
    12. 12.
      "TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing."
      Haase A.D. , Jaskiewicz L. , Zhang H. , Laine S. , Sack R. , Gatignol A. , Filipowicz W.
      EMBO Rep.6:961-967(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SELF-ASSOCIATION;INTERACTION WITH DICER1
    13. 13.
      "A human, ATP-independent, RISC assembly machine fueled by pre-miRNA."
      Maniataki E. , Mourelatos Z.
      Genes Dev.19:2979-2990(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DICER1 AND AGO2
    14. 14.
      "TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing."
      Chendrimada T.P. , Gregory R.I. , Kumaraswamy E. , Norman J. , Cooch N. , Nishikura K. , Shiekhattar R.
      Nature436:740-744(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH DICER1 AND AGO2;RNA-BINDING
    15. 15.
      "The role of PACT in the RNA silencing pathway."
      Lee Y. , Hur I. , Park S.-Y. , Kim Y.-K. , Suh M.R. , Kim V.N.
      EMBO J.25:522-532(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DICER1; AGO2 AND PRKRA;SUBCELLULAR LOCATION
    16. 16.
      "Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA."
      Kok K.H. , Ng M.-H. , Ching Y.-P. , Jin D.-Y.
      J. Biol. Chem.282:17649-17657(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SELF-ASSOCIATION;INTERACTION WITH DICER1 AND PRKRA;SUBCELLULAR LOCATION
    17. 17.
      "RNA helicase A interacts with RISC in human cells and functions in RISC loading."
      Robb G.B. , Rana T.M.
      Mol. Cell26:523-537(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DHX9
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DICER1; AGO2; EIF6 AND MOV10;ASSOCIATION WITH THE 60S RIBOSOME
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      "In vitro reconstitution of the human RISC-loading complex."
      MacRae I.J. , Ma E. , Zhou M. , Robinson C.V. , Doudna J.A.
      Proc. Natl. Acad. Sci. U.S.A.105:512-517(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH DICER1 AND AGO2
    21. 21.
      "Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions."
      Laraki G. , Clerzius G. , Daher A. , Melendez-Pena C. , Daniels S. , Gatignol A.
      RNA Biol.5:92-103(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SELF-ASSOCIATION;INTERACTION WITH EIF2AK2 AND PRKRA;SUBCELLULAR LOCATION
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      "Solution structure of the second DSRBD of TAR RNA-binding protein 2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 150-225
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