TARBP2 ELISA Kit for Human(Homo sapiens) | EIAab.comTARBP2 ELISA Kit for Human(Homo sapiens)

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TARBP2 (Gene name),

RISC-loading complex subunit TARBP2 (Protein name ), TRBP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

TARBP2(TRBP);

Protein name:

RISC-loading complex subunit TARBP2;

Alternative:

Trans-activation-responsive RNA-binding protein;TAR RNA-binding protein 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9, EIF6, MOV10 and PRKRA. Associates with the 60S ribosome.

Function:

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Subcellular Location:

Cytoplasm Cytoplasm perinuclear region Nucleus

Protein Attributes:

Sequence length:

366

Sequence:

50:

100:

150:

200:

250:

300:

350:

366:

AARRALQYLK | IMAGSK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q15633

String:

Q15633

MIM:

605053

UniGene:

Hs.326

KEGG:

hsa:6895

Pfam:

PF00035

STRING:

9606.ENSP00000266987

Uniprot:

Q15633

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ELISA Kit for Human RISC-loading complex subunit TARBP2

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E3425m

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96T

ELISA Kit for Human RISC-loading complex subunit TARBP2

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E3425r

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96T

ELISA Kit for Human RISC-loading complex subunit TARBP2

Cat.:

E3425h

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96T

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ELISA Kit for Human RISC-loading complex subunit TARBP2

Cat.:

E3425b

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96T

CLIA Kit for Human RISC-loading complex subunit TARBP2

Cat.:

U3425b

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96T

CLIA Kit for Human RISC-loading complex subunit TARBP2

Cat.:

U3425r

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96T

CLIA Kit for Human RISC-loading complex subunit TARBP2

Cat.:

U3425h

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96T

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CLIA Kit for Human RISC-loading complex subunit TARBP2

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U3425m

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96T

Polyclonal Antibody for Human RISC-loading complex subunit TARBP2

Cat.:

P3425Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human RISC-loading complex subunit TARBP2

Cat.:

P3425Rb-m

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Monoclonal Antibody for Human RISC-loading complex subunit TARBP2

Protein for Human RISC-loading complex subunit TARBP2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR."
Gatignol A. , Buckler-White A.J. , Berkhout B. , Jeang K.T.
Science251:1597-1600(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANT PHE-251
2.

Gatignol A. , Duarte M.
Submitted (2000-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)."
Kozak C.A. , Gatignol A. , Graham K. , Jeang K.T. , McBride O.W.
Genomics25:66-72(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT PHE-251
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Muscle.
7.

"Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line."
Bannwarth S. , Talakoub L. , Letourneur F. , Duarte M. , Purcell D.F. , Hiscott J. , Gatignol A.
J. Biol. Chem.276:48803-48813(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74;ALTERNATIVE PROMOTER USAGE
8.

"Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen."
Gatignol A. , Buckler C. , Jeang K.T.
Mol. Cell. Biol.13:2193-2202(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF RNA-BINDING
9.

"Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression."
Daher A. , Longuet M. , Dorin D. , Bois F. , Segeral E. , Bannwarth S. , Battisti P.-L. , Purcell D.F. , Benarous R. , Vaquero C. , Meurs E.F. , Gatignol A.
J. Biol. Chem.276:33899-33905(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SELF-ASSOCIATION;INTERACTION WITH EIF2AK2
10.

"The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR."
Dorin D. , Bonnet M.C. , Bannwarth S. , Gatignol A. , Meurs E.F. , Vaquero C.
J. Biol. Chem.278:4440-4448(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Human RISC couples microRNA biogenesis and posttranscriptional gene silencing."
Gregory R.I. , Chendrimada T.P. , Cooch N. , Shiekhattar R.
Cell123:631-640(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DICER1 AND AGO2
12.

"TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing."
Haase A.D. , Jaskiewicz L. , Zhang H. , Laine S. , Sack R. , Gatignol A. , Filipowicz W.
EMBO Rep.6:961-967(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SELF-ASSOCIATION;INTERACTION WITH DICER1
13.

"A human, ATP-independent, RISC assembly machine fueled by pre-miRNA."
Maniataki E. , Mourelatos Z.
Genes Dev.19:2979-2990(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DICER1 AND AGO2
14.

"TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing."
Chendrimada T.P. , Gregory R.I. , Kumaraswamy E. , Norman J. , Cooch N. , Nishikura K. , Shiekhattar R.
Nature436:740-744(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH DICER1 AND AGO2;RNA-BINDING
15.

"The role of PACT in the RNA silencing pathway."
Lee Y. , Hur I. , Park S.-Y. , Kim Y.-K. , Suh M.R. , Kim V.N.
EMBO J.25:522-532(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DICER1; AGO2 AND PRKRA;SUBCELLULAR LOCATION
16.

"Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA."
Kok K.H. , Ng M.-H. , Ching Y.-P. , Jin D.-Y.
J. Biol. Chem.282:17649-17657(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SELF-ASSOCIATION;INTERACTION WITH DICER1 AND PRKRA;SUBCELLULAR LOCATION
17.

"RNA helicase A interacts with RISC in human cells and functions in RISC loading."
Robb G.B. , Rana T.M.
Mol. Cell26:523-537(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DHX9
18.

"MicroRNA silencing through RISC recruitment of eIF6."
Chendrimada T.P. , Finn K.J. , Ji X. , Baillat D. , Gregory R.I. , Liebhaber S.A. , Pasquinelli A.E. , Shiekhattar R.
Nature447:823-828(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DICER1; AGO2; EIF6 AND MOV10;ASSOCIATION WITH THE 60S RIBOSOME
19.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"In vitro reconstitution of the human RISC-loading complex."
MacRae I.J. , Ma E. , Zhou M. , Robinson C.V. , Doudna J.A.
Proc. Natl. Acad. Sci. U.S.A.105:512-517(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH DICER1 AND AGO2
21.

"Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions."
Laraki G. , Clerzius G. , Daher A. , Melendez-Pena C. , Daniels S. , Gatignol A.
RNA Biol.5:92-103(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SELF-ASSOCIATION;INTERACTION WITH EIF2AK2 AND PRKRA;SUBCELLULAR LOCATION
22.

"A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function."
Melo S.A. , Ropero S. , Moutinho C. , Aaltonen L.A. , Yamamoto H. , Calin G.A. , Rossi S. , Fernandez A.F. , Carneiro F. , Oliveira C. , Ferreira B. , Liu C.-G. , Villanueva A. , Capella G. , Schwartz S. Jr. , Shiekhattar R. , Esteller M.
Nat. Genet.41:365-370(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.

"Solution structure of the second DSRBD of TAR RNA-binding protein 2."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 150-225

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