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Index > Protein center > TRIM37(Gene name) > Human
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  • TRIM37 (Gene name),
  • E3 ubiquitin-protein ligase TRIM37 (Protein name ),  TRI37_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TRIM37(KIAA0898;MUL;POB1);
    Protein name:
    E3 ubiquitin-protein ligase TRIM37;
    Alternative:
    Tripartite motif-containing protein 37;Mulibrey nanism protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    E3 ubiquitin-protein ligase.
    Subcellular Location:
    Cytoplasm perinuclear region Peroxisome Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
    Protein Attributes:
    Sequence length:
    964
    Sequence:
    50:
    MDEQSVESIA | EVFRCFICME | KLRDARLCPH | CSKLCCFSCI | RRWLTEQRAQ | 
    100:
    CPHCRAPLQL | RELVNCRWAE | EVTQQLDTLQ | LCSLTKHEEN | EKDKCENHHE | 
    150:
    KLSVFCWTCK | KCICHQCALW | GGMHGGHTFK | PLAEIYEQHV | TKVNEEVAKL | 
    200:
    RRRLMELISL | VQEVERNVEA | VRNAKDERVR | EIRNAVEMMI | ARLDTQLKNK | 
    250:
    LITLMGQKTS | LTQETELLES | LLQEVEHQLR | SCSKSELISK | SSEILMMFQQ | 
    300:
    VHRKPMASFV | TTPVPPDFTS | ELVPSYDSAT | FVLENFSTLR | QRADPVYSPP | 
    350:
    LQVSGLCWRL | KVYPDGNGVV | RGYYLSVFLE | LSAGLPETSK | YEYRVEMVHQ | 
    400:
    SCNDPTKNII | REFASDFEVG | ECWGYNRFFR | LDLLANEGYL | NPQNDTVILR | 
    450:
    FQVRSPTFFQ | KSRDQHWYIT | QLEAAQTSYI | QQINNLKERL | TIELSRTQKS | 
    500:
    RDLSPPDNHL | SPQNDDALET | RAKKSACSDM | LLEGGPTTAS | VREAKEDEED | 
    550:
    EEKIQNEDYH | HELSDGDLDL | DLVYEDEVNQ | LDGSSSSASS | TATSNTEEND | 
    600:
    IDEETMSGEN | DVEYNNMELE | EGELMEDAAA | AGPAGSSHGY | VGSSSRISRR | 
    650:
    THLCSAATSS | LLDIDPLILI | HLLDLKDRSS | IENLWGLQPR | PPASLLQPTA | 
    700:
    SYSRKDKDQR | KQQAMWRVPS | DLKMLKRLKT | QMAEVRCMKT | DVKNTLSEIK | 
    750:
    SSSAASGDMQ | TSLFSADQAA | LAACGTENSG | RLQDLGMELL | AKSSVANCYI | 
    800:
    RNSTNKKSNS | PKPARSSVAG | SLSLRRAVDP | GENSRSKGDC | QTLSEGSPGS | 
    850:
    SQSGSRHSSP | RALIHGSIGD | ILPKTEDRQC | KALDSDAVVV | AVFSGLPAVE | 
    900:
    KRRKMVTLGA | NAKGGHLEGL | QMTDLENNSE | TGELQPVLPE | GASAAPEEGM | 
    950:
    SSDSDIECDT | ENEEQEEHTS | VGGFHDSFMV | MTQPPDEDTH | SSFPDGEQIG | 
    964:
    PEDLSFNTDE | NSGR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    MIM:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase TRIM37
    ELISA Kit for Human E3 ubiquitin-protein ligase TRIM37
    CLIA Kit for Human E3 ubiquitin-protein ligase TRIM37
    CLIA Kit for Human E3 ubiquitin-protein ligase TRIM37
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase TRIM37
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase TRIM37
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase TRIM37
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase TRIM37
    Protein for Human E3 ubiquitin-protein ligase TRIM37
    Protein for Human E3 ubiquitin-protein ligase TRIM37

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Gene POB1 is amplified and overexpressed in human breast cancer."
      Wu G. , Couch F.J.
      Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-108
      tissue: Testis.
    5. 5.
      "Gene encoding a new RING-B-box-coiled-coil protein is mutated in mulibrey nanism."
      Avela K. , Lipsanen-Nyman M. , Idanheimo N. , Seemanova E. , Rosengren S. , Makela T.P. , Perheentupa J. , Chapelle A.D. , Lehesjoki A.E.
      Nat. Genet.25:298-301(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;TISSUE SPECIFICITY
    6. 6.
      "The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder."
      Kallijarvi J. , Avela K. , Lipsanen-Nyman M. , Ulmanen I. , Lehesjoki A.E.
      Am. J. Hum. Genet.70:1215-1228(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    7. 7.
      "A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity."
      Jagiello P. , Hammans C. , Wieczorek S. , Arning L. , Stefanski A. , Strehl H. , Epplen J.T. , Gencik M.
      Hum. Mutat.21:630-635(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
    8. 8.
      "TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase."
      Kallijaervi J. , Lahtinen U. , Haemaelaeinen R. , Lipsanen-Nyman M. , Palvimo J.J. , Lehesjoki A.-E.
      Exp. Cell Res.308:146-155(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;AUTOUBIQUITINATION;MUTAGENESIS OF 35-CYS-CYS-36;VARIANT MUL PRO-76;CHARACTERIZATION OF VARIANTS MUL PRO-76 AND MUL VAL-322
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells."
      Balestra F.R. , Strnad P. , Fluckiger I. , Gonczy P.
      Dev. Cell25:555-571(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MUL VAL-322;CHARACTERIZATION OF VARIANT MUL VAR-322
    12. 12.
      "Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism."
      Haemaelaeinen R.H. , Mowat D. , Gabbett M.T. , O'brien T.A. , Kallijaervi J. , Lehesjoki A.-E.
      Clin. Genet.70:473-479(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MUL SER-109;CHARACTERIZATION OF VARIANT MUL SER-109
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