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Index > Protein center > TREML1(Gene name) > Human
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  • TREML1 (Gene name),
  • Trem-like transcript 1 protein (Protein name ),  TRML1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TREML1(UNQ1825/PRO3438;TLT1);
    Protein name:
    Trem-like transcript 1 protein(TLT-1);
    Alternative:
    Triggering receptor expressed on myeloid cells-like protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.
    Function:
    Cell surface receptor that may play a role in the innate and adaptive immune response.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Cytoplasm Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis.
    Protein Attributes:
    Sequence length:
    311
    Sequence:
    50:
    MGLTLLLLLL | LGLEGQGIVG | SLPEVLQAPV | GSSILVQCHY | RLQDVKAQKV | 
    100:
    WCRFLPEGCQ | PLVSSAVDRR | APAGRRTFLT | DLGGGLLQVE | MVTLQEEDAG | 
    150:
    EYGCMVDGAR | GPQILHRVSL | NILPPEEEEE | THKIGSLAEN | AFSDPAGSAN | 
    200:
    PLEPSQDEKS | IPLIWGAVLL | VGLLVAAVVL | FAVMAKRKQG | NRLGVCGRFL | 
    250:
    SSRVSGMNPS | SVVHHVSDSG | PAAELPLDVP | HIRLDSPPSF | DNTTYTSLPL | 
    300:
    DSPSGKPSLP | APSSLPPLPP | KVLVCSKPVT | YATVIFPGGN | KGGGTSCGPA | 
    311:
    QNPPNNQTPS | S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human TLT-1
    Cat.:
    E2261h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human TLT-1
    Cat.:
    E2261m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TLT-1
    Cat.:
    U2261m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TLT-1
    Cat.:
    U2261h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human TLT-1
    Cat.:
    P2261Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TLT-1
    Cat.:
    P2261Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human TLT-1
    Monoclonal Antibody for Human TLT-1
    Protein for Human TLT-1
    Protein for Human TLT-1

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster."
      Washington A.V. , Quigley L. , McVicar D.W.
      Blood100:3822-3824(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44."
      Allcock R.J.N. , Barrow A.D. , Forbes S. , Beck S. , Trowsdale J.
      Eur. J. Immunol.33:567-577(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
    3. 3.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
    6. 6.
      "A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets."
      Washington A.V. , Schubert R.L. , Quigley L. , Disipio T. , Feltz R. , Cho E.H. , McVicar D.W.
      Blood104:1042-1047(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    7. 7.
      "TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2."
      Barrow A.D. , Astoul E. , Floto A. , Brooke G. , Relou I.A.M. , Jennings N.S. , Smith K.G.C. , Ouwehand W. , Farndale R.W. , Alexander D.R. , Trowsdale J.
      J. Immunol.172:5838-5842(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;INTERACTION WITH PTPN11;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    8. 8.
      "Proteomic analysis of palmitoylated platelet proteins."
      Dowal L. , Yang W. , Freeman M.R. , Steen H. , Flaumenhaft R.
      Blood118:E62-E73(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-196
      tissue: Platelet.
    9. 9.
      "The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment."
      Gattis J.L. , Washington A.V. , Chisholm M.M. , Quigley L. , Szyk A. , McVicar D.W. , Lubkowski J.
      J. Biol. Chem.281:13396-13403(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.19 ANGSTROMS) OF 20-125;DISULFIDE BONDS;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-6
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