Gene name:
TREML1 (UNQ1825/PRO3438;TLT1) ;
Protein name:
Trem-like transcript 1 protein (TLT-1) ;
Alternative:
Triggering receptor expressed on myeloid cells-like protein 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.
Function:
Cell surface receptor that may play a role in the innate and adaptive immune response.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Cytoplasm
Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis.
Protein Attributes:
50:
MGLTLLLLLL | LGLEGQGIVG | SLPEVLQAPV | GSSILVQCHY | RLQDVKAQKV |
100:
WCRFLPEGCQ | PLVSSAVDRR | APAGRRTFLT | DLGGGLLQVE | MVTLQEEDAG |
150:
EYGCMVDGAR | GPQILHRVSL | NILPPEEEEE | THKIGSLAEN | AFSDPAGSAN |
200:
PLEPSQDEKS | IPLIWGAVLL | VGLLVAAVVL | FAVMAKRKQG | NRLGVCGRFL |
250:
SSRVSGMNPS | SVVHHVSDSG | PAAELPLDVP | HIRLDSPPSF | DNTTYTSLPL |
300:
DSPSGKPSLP | APSSLPPLPP | KVLVCSKPVT | YATVIFPGGN | KGGGTSCGPA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human TLT-1
ELISA Kit for Human TLT-1
Polyclonal Antibody for Human TLT-1
Polyclonal Antibody for Human TLT-1
Monoclonal Antibody for Human TLT-1
Monoclonal Antibody for Human TLT-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
3.
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F.
,
Gurney A.L.
,
Abaya E.
,
Baker K.
,
Baldwin D.T.
,
Brush J.
,
Chen J.
,
Chow B.
,
Chui C.
,
Crowley C.
,
Currell B.
,
Deuel B.
,
Dowd P.
,
Eaton D.
,
Foster J.S.
,
Grimaldi C.
,
Gu Q.
,
Hass P.E.
,
Heldens S.
,
Huang A.
,
Kim H.S.
,
Klimowski L.
,
Jin Y.
,
Johnson S.
,
Lee J.
,
Lewis L.
,
Liao D.
,
Mark M.R.
,
Robbie E.
,
Sanchez C.
,
Schoenfeld J.
,
Seshagiri S.
,
Simmons L.
,
Singh J.
,
Smith V.
,
Stinson J.
,
Vagts A.
,
Vandlen R.L.
,
Watanabe C.
,
Wieand D.
,
Woods K.
,
Xie M.-H.
,
Yansura D.G.
,
Yi S.
,
Yu G.
,
Yuan J.
,
Zhang M.
,
Zhang Z.
,
Goddard A.D.
,
Wood W.I.
,
Godowski P.J.
,
Gray A.M.
more...
Genome Res.13:2265-2270(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
4.
"The DNA sequence and analysis of human chromosome 6."
Mungall A.J.
,
Palmer S.A.
,
Sims S.K.
,
Edwards C.A.
,
Ashurst J.L.
,
Wilming L.
,
Jones M.C.
,
Horton R.
,
Hunt S.E.
,
Scott C.E.
,
Gilbert J.G.R.
,
Clamp M.E.
,
Bethel G.
,
Milne S.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Andrews T.D.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Barker D.J.
,
Barlow K.F.
,
Bates K.
,
Beare D.M.
,
Beasley H.
,
Beasley O.
,
Bird C.P.
,
Blakey S.E.
,
Bray-Allen S.
,
Brook J.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.C.
,
Burrill W.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Clark S.Y.
,
Clark G.
,
Clee C.M.
,
Clegg S.
,
Cobley V.
,
Collier R.E.
,
Collins J.E.
,
Colman L.K.
,
Corby N.R.
,
Coville G.J.
,
Culley K.M.
,
Dhami P.
,
Davies J.
,
Dunn M.
,
Earthrowl M.E.
,
Ellington A.E.
,
Evans K.A.
,
Faulkner L.
,
Francis M.D.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Ghori M.J.
,
Gilby L.M.
,
Gillson C.J.
,
Glithero R.J.
,
Grafham D.V.
,
Grant M.
,
Gribble S.
,
Griffiths C.
,
Griffiths M.N.D.
,
Hall R.
,
Halls K.S.
,
Hammond S.
,
Harley J.L.
,
Hart E.A.
,
Heath P.D.
,
Heathcott R.
,
Holmes S.J.
,
Howden P.J.
,
Howe K.L.
,
Howell G.R.
,
Huckle E.
,
Humphray S.J.
,
Humphries M.D.
,
Hunt A.R.
,
Johnson C.M.
,
Joy A.A.
,
Kay M.
,
Keenan S.J.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leongamornlert D.A.
,
Leversha M.
,
Lloyd C.R.
,
Lloyd D.M.
,
Loveland J.E.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Maslen G.L.
,
Matthews L.
,
McCann O.T.
,
McLaren S.J.
,
McLay K.
,
McMurray A.
,
Moore M.J.F.
,
Mullikin J.C.
,
Niblett D.
,
Nickerson T.
,
Novik K.L.
,
Oliver K.
,
Overton-Larty E.K.
,
Parker A.
,
Patel R.
,
Pearce A.V.
,
Peck A.I.
,
Phillimore B.J.C.T.
,
Phillips S.
,
Plumb R.W.
,
Porter K.M.
,
Ramsey Y.
,
Ranby S.A.
,
Rice C.M.
,
Ross M.T.
,
Searle S.M.
,
Sehra H.K.
,
Sheridan E.
,
Skuce C.D.
,
Smith S.
,
Smith M.
,
Spraggon L.
,
Squares S.L.
,
Steward C.A.
,
Sycamore N.
,
Tamlyn-Hall G.
,
Tester J.
,
Theaker A.J.
,
Thomas D.W.
,
Thorpe A.
,
Tracey A.
,
Tromans A.
,
Tubby B.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
White S.S.
,
Whitehead S.L.
,
Whittaker H.
,
Wild A.
,
Willey D.J.
,
Wilmer T.E.
,
Wood J.M.
,
Wray P.W.
,
Wyatt J.C.
,
Young L.
,
Younger R.M.
,
Bentley D.R.
,
Coulson A.
,
Durbin R.M.
,
Hubbard T.
,
Sulston J.E.
,
Dunham I.
,
Rogers J.
,
Beck S.
more...
Nature425:805-811(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.
"TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2."
Barrow A.D.
,
Astoul E.
,
Floto A.
,
Brooke G.
,
Relou I.A.M.
,
Jennings N.S.
,
Smith K.G.C.
,
Ouwehand W.
,
Farndale R.W.
,
Alexander D.R.
,
Trowsdale J.
J. Immunol.172:5838-5842(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION;INTERACTION WITH PTPN11;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PALMITOYLATION AT CYS-196
tissue :
Platelet .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.19 ANGSTROMS) OF 20-125;DISULFIDE BONDS;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
10.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] VAL-6