Protein name:
Short transient receptor potential channel 4 (TrpC4) ;
Alternative:
Capacitative calcium entry channel 1 (CCE1) ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homotetramer and heterotetramer with TRPC1 and/or TRPC5 (By similarity). Isoform alpha associates with inositol-1,4,5-triphosphate receptor (ITPR). Interacts with (via the PDZ-binding domain) with NHERF (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts (via CIRB domain) with SESTD1 (via the spectrin 1 repeat) (By similarity). Interacts with CDH5 and CTNNB1 (By similarity). Interacts (via protein 4.1-binding domain) with EPB41L2 (By similarity). Interacts with TRPC4AP.
Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Acts as a cell-cell contact-dependent endothelial calcium entry channel.
Subcellular Location:
Membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MAQFYYKRNV | NAPYRDRIPL | RIVRAESELS | PSEKAYLNAV | EKGDYASVKK |
100:
SLEEAEIYFK | ININCIDPLG | RTALLIAIEN | ENLELIELLL | SFNVYVGDAL |
150:
LHAIRKEVVG | AVELLLNHKK | PSGEKQVPPI | LLDKQFSEFT | PDITPIILAA |
200:
HTNNYEIIKL | LVQKGVSVPR | PHEVRCNCVE | CVSSSDVDSL | RHSRSRLNIY |
250:
KALASPSLIA | LSSEDPFLTA | FQLSWELQEL | SKVENEFKSE | YEELSRQCKQ |
300:
FAKDLLDQTR | SSRELEIILN | YRDDNSLLEE | QSGNDLARLK | LAIKYRQKEF |
350:
VAQPNCQQLL | ASRWYDEFPG | WRRRHWAVKM | VTCFIVGLLF | PVFSVCYLIA |
400:
PKSPLGLFIR | KPFIKFICHT | ASYLTFLFLL | LLASQHIDRS | DLNRQGPPPT |
450:
IVEWMILPWV | LGFIWGEIKQ | MWDGGLQDYI | HDWWNLMDFV | MNSLYLATIS |
500:
LKIVAFVKYS | ALNPRESWDM | WHPTLVAEAL | FAIANIFSSL | RLISLFTANS |
550:
HLGPLQISLG | RMLLDILKFL | FIYCLVLLAF | ANGLNQLYFY | YEETKGLSCK |
600:
GIRCEKQNNA | FSTLFETLQS | LFWSIFGLIN | LYVTNVKAQH | EFTEFVGATM |
650:
FGTYNVISLV | VLLNMLIAMM | NNSYQLIADH | ADIEWKFART | KLWMSYFEEG |
700:
GTLPTPFNVI | PSPKSLWYLI | KWIWTHLCKK | KMRRKPESFG | TIGRRAADNL |
750:
RRHHQYQEVM | RNLVKRYVAA | MIRDAKTEEG | LTEENFKELK | QDISSFRFEV |
800:
LGLLRGSKLS | TVQSAQGTKE | SSNSADSDEK | SDNEGSSKDK | KKNFSLFDLT |
850:
TLIHPRSAAI | AAERHTISNG | SALVVQEPPR | EKQRKVNFVT | DIRHFGLFHR |
900:
RSKQHAAAEQ | NANQIFSVSE | GVARQQAEGP | LERSIQLESR | TLASRGDLNI |
950:
PGLSEQCILV | DHRERNTDSL | GVQVSKRVCS | FKSEKVVVED | TVPIIPKEKK |
979:
HAKEEDSSAD | YDANLTDTIT | HEDYVTTRL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
Rat
ELISA Kit for Bovine TrpC4
ELISA Kit for Bovine TrpC4
ELISA Kit for Bovine TrpC4
ELISA Kit for Bovine TrpC4
CLIA Kit for Bovine TrpC4
CLIA Kit for Bovine TrpC4
CLIA Kit for Bovine TrpC4
CLIA Kit for Bovine TrpC4
Polyclonal Antibody for Bovine TrpC4
Polyclonal Antibody for Bovine TrpC4
Polyclonal Antibody for Bovine TrpC4
Polyclonal Antibody for Bovine TrpC4
Monoclonal Antibody for Bovine TrpC4
Monoclonal Antibody for Bovine TrpC4
Monoclonal Antibody for Bovine TrpC4
Monoclonal Antibody for Bovine TrpC4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
tissue :
Adrenal gland .
tissue :
Retina .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA)
tissue :
Adrenal gland .