Trpc4 ELISA Kit for Mouse(Mus musculus) | EIAab.comTrpc4 ELISA Kit for Mouse(Mus musculus)

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Trpc4 (Gene name),

Short transient receptor potential channel 4 (Protein name ), TRPC4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Trpc4(Trrp4);

Protein name:

Short transient receptor potential channel 4(TrpC4);

Alternative:

Receptor-activated cation channel TRP4;Capacitative calcium entry channel Trp4;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotetramer. Heterotetramer with TRPC1 and/or TRPC5 (By similarity). Isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR) (By similarity). Interacts with NHERF. Interacts with MX1 and RNF24 (By similarity). Interacts (via CIRB domain) with SESTD1 (via the spectrin 1 repeat) and SPTBN5 (via C-terminus) (By similarity). Interacts with CDH5 and CTNNB1 (By similarity). Interacts (via protein 4.1-binding domain) with EPB41L2 (By similarity). Interacts with TRPC4AP.

Function:

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells.

Subcellular Location:

Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

974

Sequence:

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950:

974:

DSSIDYDLSP | TDTAAHEDYV | TTRL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.10100

KEGG:

mmu:22066

Pfam:

PF00023

Pfam:

PF12796

String:

Q9QUQ5

SMR:

Q9QUQ5

Uniprot:

Q9QUQ5

FOR

ELISA Kit for Mouse TrpC4

CLIA Kit for Mouse TrpC4

Polyclonal Antibody for Mouse TrpC4

Monoclonal Antibody for Mouse TrpC4

Protein for Mouse TrpC4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Trp4 is involved in capacitative calcium entry in murine cells."
Zhu X. , Boulay G. , Jiang M. , Birnbaumer L.
Submitted (1997-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
tissue: Brain.
2.

Qian F. , Philipson L.H.
Submitted (1996-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
3.

"Differential distribution of TRP Ca2+ channel isoforms in mouse brain."
Mori Y. , Takada N. , Okada T. , Wakamori M. , Imoto K. , Wanifuchi H. , Oka H. , Oba A. , Ikenaka K. , Kurosaki T.
NeuroReport9:507-515(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
tissue: Brain.
4.

"Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF."
Tang Y. , Tang J. , Chen Z. , Trost C. , Flockerzi V. , Li M. , Ramesh V. , Zhu M.X.
J. Biol. Chem.275:37559-37564(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
5.

"Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues."
Petersen C.C.H. , Berridge M.J. , Borgese M.F. , Bennett D.L.
Biochem. J.311:41-44(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 505-642
tissue: Brain.
6.

"Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice."
Freichel M. , Suh S.H. , Pfeifer A. , Schweig U. , Trost C. , Weissgerber P. , Biel M. , Philipp S. , Freise D. , Droogmans G. , Hofmann F. , Flockerzi V. , Nilius B.
Nat. Cell Biol.3:121-127(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"The self-association of two N-terminal interaction domains plays an important role in the tetramerization of TRPC4."
Lepage P.K. , Lussier M.P. , McDuff F.O. , Lavigne P. , Boulay G.
Cell Calcium45:251-259(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
8.

"TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling."
Mace K.E. , Lussier M.P. , Boulay G. , Terry-Powers J.L. , Parfrey H. , Perraud A.L. , Riches D.W.H.
J. Cell. Physiol.225:444-453(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRPC4AP

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