THBS1 ELISA Kit for Human(Homo sapiens) | EIAab.comTHBS1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > THBS1(Gene name) > Human

THBS1 (Gene name),

Thrombospondin-1 (Protein name ), TSP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

THBS1(TSP;TSP1);

Protein name:

Thrombospondin-1;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect.

Function:

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

1170

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1170:

FVFSQEMVFF | SDLKYECRDP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P07996

KEGG:

hsa:7057

Pfam:

PF07645

MIM:

188060

UniGene:

Hs.164226

String:

P07996

STRING:

9606.ENSP00000260356

Uniprot:

P07996

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ELISA Kit for Human Thrombospondin-1

Cat.:

E0611m

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96T

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ELISA Kit for Human Thrombospondin-1

Cat.:

E0611h

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96T

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ELISA Kit for Human Thrombospondin-1

Cat.:

E0611b

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Packing:

96T

CLIA Kit for Human Thrombospondin-1

Cat.:

U0611b

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Packing:

96T

CLIA Kit for Human Thrombospondin-1

Cat.:

U0611h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Thrombospondin-1

Cat.:

U0611m

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Manual:

Looking for manual.

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96T

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Polyclonal Antibody for Human Thrombospondin-1

Cat.:

P0611Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Thrombospondin-1

Cat.:

P0611Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Thrombospondin-1

Protein for Human Thrombospondin-1

Cat.:

R0611h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human Thrombospondin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins."
Lawler J. , Hynes R.O.
J. Cell Biol.103:1635-1648(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Endothelial cell.
2.

"Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region."
Hennessy S.W. , Frazier B.A. , Kim D.D. , Deckwerth T.L. , Baumgartel D.M. , Rotwein P. , Frazier W.A.
J. Cell Biol.108:729-736(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-523
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ALA-523
tissue: Placenta.
tissue: Uterus.
4.

"Homo sapiens protein coding cDNA."
Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-700
tissue: Aortic endothelium.
5.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Testis.
7.

"Partial amino acid sequence of human thrombospondin as determined by analysis of cDNA clones: homology to malarial circumsporozoite proteins."
Kobayashi S. , Eden-Mccutchan F. , Framson P. , Bornstein P.
Biochemistry25:8418-8425(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-397 (ISOFORM 1)
8.

"Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin."
Dixit V.M. , Hennessy S.W. , Grant G.A. , Rotwein P. , Frazier W.A.
Proc. Natl. Acad. Sci. U.S.A.83:5449-5453(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-374 (ISOFORM 1)
9.

"Characterization of the promoter region of the human thrombospondin gene. DNA sequences within the first intron increase transcription."
Laherty C.D. , Gierman T.M. , Dixit V.M.
J. Biol. Chem.264:11222-11227(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-166
10.

"Expression of thrombospondin in chronic inflammation: neutrophils from synovial fluids synthesize a novel 3.9 kb TSP mRNA."
la Fleur M. , Jobin C. , Gauthier J. , Kreis C.G.
Submitted (1992-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1028-1170 (ISOFORM 1)
11.

"Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding."
Asch A.S. , Silbiger S. , Heimer E. , Nachman R.L.
Biochem. Biophys. Res. Commun.182:1208-1217(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD36
12.

"C-mannosylation and O-fucosylation of the thrombospondin type 1 module."
Hofsteenge J. , Huwiler K.G. , Macek B. , Hess D. , Lawler J. , Mosher D.F. , Peter-Katalinic J.
J. Biol. Chem.276:6485-6498(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-385; SER-394; TRP-438; TRP-441; THR-450; TRP-498 AND THR-507
tissue: Platelet.
13.

"Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1."
Simantov R. , Febbraio M. , Crombie R. , Asch A.S. , Nachman R.L. , Silverstein R.L.
J. Clin. Invest.107:45-52(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HRG;FUNCTION
14.

"Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1."
Huwiler K.G. , Vestling M.M. , Annis D.S. , Mosher D.F.
Biochemistry41:14329-14339(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS IN THROMBOSPONDIN DOMAIN
15.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-248 AND ASN-1067
tissue: Plasma.
16.

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
Ramachandran P. , Boontheung P. , Xie Y. , Sondej M. , Wong D.T. , Loo J.A.
J. Proteome Res.5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1067
tissue: Saliva.
17.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-248
tissue: Platelet.
18.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1067
tissue: Liver.
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication."
Tan K. , Duquette M. , Liu J.-H. , Dong Y. , Zhang R. , Joachimiak A. , Lawler J. , Wang J.-H.
J. Cell Biol.159:373-382(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 434-546;DISULFIDE BONDS;GLYCOSYLATION AT THR-450 AND THR-507
21.

"Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats."
Kvansakul M. , Adams J.C. , Hohenester E.
EMBO J.23:1223-1233(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 834-1170 IN COMPLEX WITH CALCIUM IONS;DISULFIDE BONDS;MUTAGENESIS OF ASN-1067;GLYCOSYLATION AT ASN-1067;CELL ATTACHMENT SITE;FUNCTION
22.

"The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin."
Tan K. , Duquette M. , Liu J.-H. , Zhang R. , Joachimiak A. , Wang J.-H. , Lawler J.
Structure14:33-42(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 19-233 IN COMPLEX WITH SYNTHETIC PENTAMERIC HEPARIN;DISULFIDE BOND
23.

"Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain."
Tan K. , Duquette M. , Liu J.-H. , Shanmugasundaram K. , Joachimiak A. , Gallagher J.T. , Rigby A.C. , Wang J.-H. , Lawler J.
J. Biol. Chem.283:3932-3941(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 19-257 IN COMPLEXES WITH HEPARIN;IDENTIFICATION BY MASS SPECTROMETRY;GLYCOSYLATION AT ASN-248

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