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Index > Protein center > TTF2(Gene name) > Human
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  • TTF2 (Gene name),
  • Transcription termination factor 2 (Protein name ),  TTF2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TTF2;
    Protein name:
    Transcription termination factor 2;
    Alternative:
    RNA polymerase II termination factor;Lodestar homolog;Transcription release factor 2(F2;HuF2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CDC5L. Part of the spliceosome.
    Function:
    DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
    Subcellular Location:
    Cytoplasm Nucleus Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
    Protein Attributes:
    Sequence length:
    1162
    Sequence:
    50:
    MEEVRCPEHG | TFCFLKTGVR | DGPNKGKSFY | VCRADTCSFV | RATDIPVSHC | 
    100:
    LLHEDFVVEL | QGLLLPQDKK | EYRLFFRCIR | SKAEGKRWCG | SIPWQDPDSK | 
    150:
    EHSVSNKSQH | ASETFHHSSN | WLRNPFKVLD | KNQEPALWKQ | LIKGEGEEKK | 
    200:
    ADKKQREKGD | QLFDQKKEQK | PEMMEKDLSS | GLVPKKKQSV | VQEKKQEEGA | 
    250:
    EIQCEAETGG | THKRDFSEIK | SQQCQGNELT | RPSASSQEKS | SGKSQDVQRE | 
    300:
    SEPLREKVTQ | LLPQNVHSHN | SISKPQKGGP | LNKEYTNWEA | KETKAKDGPS | 
    350:
    IQATQKSLPQ | GHFQERPETH | SVPAPGGPAA | QAAPAAPGLS | LGEGREAATS | 
    400:
    SDDEEEDDVV | FVSSKPGSPL | LFDSTLDLET | KENLQFPDRS | VQRKVSPASG | 
    450:
    VSKKVEPSDP | VARRVYLTTQ | LKQKKSTLAS | VNIQALPDKG | QKLIKQIQEL | 
    500:
    EEVLSGLTLS | PEQGTNEKSN | SQVPQQSHFT | KTTTGPPHLV | PPQPLPRRGT | 
    550:
    QPVGSLELKS | ACQVTAGGSS | QCYRGHTNQD | HVHAVWKITS | EAIGQLHRSL | 
    600:
    ESCPGETVVA | EDPAGLKVPL | LLHQKQALAW | LLWRESQKPQ | GGILADDMGL | 
    650:
    GKTLTMIALI | LTQKNQEKKE | EKEKSTALTW | LSKDDSCDFT | SHGTLIICPA | 
    700:
    SLIHHWKNEV | EKRVNSNKLR | VYLYHGPNRD | SRARVLSTYD | IVITTYSLVA | 
    750:
    KEIPTNKQEA | EIPGANLNVE | GTSTPLLRIA | WARIILDEAH | NVKNPRVQTS | 
    800:
    IAVCKLQACA | RWAVTGTPIQ | NNLLDMYSLL | KFLRCSPFDE | FNLWRSQVDN | 
    850:
    GSKKGGERLS | ILTKSLLLRR | TKDQLDSTGR | PLVILPQRKF | QLHHLKLSED | 
    900:
    EETVYNVFFA | RSRSALQSYL | KRHESRGNQS | GRSPNNPFSR | VALEFGSEEP | 
    950:
    RHSEAADSPR | SSTVHILSQL | LRLRQCCCHL | SLLKSALDPM | ELKGEGLVLS | 
    1000:
    LEEQLSALTL | SELRDSEPSS | TVSLNGTFFK | MELFEGMRES | TKISSLLAEL | 
    1050:
    EAIQRNSASQ | KSVIVSQWTN | MLKVVALHLK | KHGLTYATID | GSVNPKQRMD | 
    1100:
    LVEAFNHSRG | PQVMLISLLA | GGVGLNLTGG | NHLFLLDMHW | NPSLEDQACD | 
    1150:
    RIYRVGQQKD | VVIHRFVCEG | TVEEKILQLQ | EKKKDLAKQV | LSGSGESVTK | 
    1162:
    LTLADLRVLF | GI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    UniGene:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Transcription termination factor 2
    Cat.:
    E5423h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Transcription termination factor 2
    Cat.:
    E5423m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Transcription termination factor 2
    Cat.:
    U5423h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Transcription termination factor 2
    Cat.:
    U5423m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Transcription termination factor 2
    Cat.:
    P5423Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Transcription termination factor 2
    Cat.:
    P5423Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Transcription termination factor 2
    Monoclonal Antibody for Human Transcription termination factor 2
    Protein for Human Transcription termination factor 2
    Protein for Human Transcription termination factor 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member."
      Liu M. , Xie Z. , Price D.H.
      J. Biol. Chem.273:25541-25544(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
    2. 2.
      "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing."
      Leonard D. , Ajuh P. , Lamond A.I. , Legerski R.J.
      Biochem. Biophys. Res. Commun.308:793-801(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH CDC5L;IDENTIFICATION AS PART OF THE SPLICEOSOME;VARIANT HIS-1155
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-167
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    6. 6.
      "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer."
      Hara R. , Selby C.P. , Liu M. , Price D.H. , Sancar A.
      J. Biol. Chem.274:24779-24786(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation."
      Jiang Y. , Liu M. , Spencer C.A. , Price D.H.
      Mol. Cell14:375-385(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460 AND SER-883;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460 AND SER-908;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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