Protein name:
Tyrosinase ;
Alternative:
Monophenol monooxygenase ;LB24-AB ;Tumor rejection antigen AB ;SK29-AB ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Subcellular Location:
Melanosome membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MLLAVLYCLL | WSFQTSAGHF | PRACVSSKNL | MEKECCPPWS | GDRSPCGQLS |
100:
GRGSCQNILL | SNAPLGPQFP | FTGVDDRESW | PSVFYNRTCQ | CSGNFMGFNC |
150:
GNCKFGFWGP | NCTERRLLVR | RNIFDLSAPE | KDKFFAYLTL | AKHTISSDYV |
200:
IPIGTYGQMK | NGSTPMFNDI | NIYDLFVWMH | YYVSMDALLG | GSEIWRDIDF |
250:
AHEAPAFLPW | HRLFLLRWEQ | EIQKLTGDEN | FTIPYWDWRD | AEKCDICTDE |
300:
YMGGQHPTNP | NLLSPASFFS | SWQIVCSRLE | EYNSHQSLCN | GTPEGPLRRN |
350:
PGNHDKSRTP | RLPSSADVEF | CLSLTQYESG | SMDKAANFSF | RNTLEGFASP |
400:
LTGIADASQS | SMHNALHIYM | NGTMSQVQGS | ANDPIFLLHH | AFVDSIFEQW |
450:
LRRHRPLQEV | YPEANAPIGH | NRESYMVPFI | PLYRNGDFFI | SSKDLGYDYS |
500:
YLQDSDPDSF | QDYIKSYLEQ | ASRIWSWLLG | AAMVGAVLTA | LLAGLVSLLC |
529:
RHKRKQLPEE | KQPLLMEKED | YHSLYQSHL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Dog
Bovine
Chicken
ELISA Kit for Human Tyrosinase
ELISA Kit for Human Tyrosinase
ELISA Kit for Human Tyrosinase
ELISA Kit for Human Tyrosinase
ELISA Kit for Human Tyrosinase
CLIA Kit for Human Tyrosinase
CLIA Kit for Human Tyrosinase
CLIA Kit for Human Tyrosinase
CLIA Kit for Human Tyrosinase
CLIA Kit for Human Tyrosinase
Polyclonal Antibody for Human Tyrosinase
Polyclonal Antibody for Human Tyrosinase
Polyclonal Antibody for Human Tyrosinase
Polyclonal Antibody for Human Tyrosinase
Polyclonal Antibody for Human Tyrosinase
Monoclonal Antibody for Human Tyrosinase
Monoclonal Antibody for Human Tyrosinase
Monoclonal Antibody for Human Tyrosinase
Monoclonal Antibody for Human Tyrosinase
Monoclonal Antibody for Human Tyrosinase
Protein for Human Tyrosinase
Protein for Human Tyrosinase
Protein for Human Tyrosinase
Protein for Human Tyrosinase
Protein for Human Tyrosinase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM;SEQUENCE REVISION TO 384-398
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Melanoma .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE (ISOFORM 1)
tissue :
Melanoma .
tissue :
T-cell .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT TYR-192
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Skin .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-272
tissue :
Liver .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-32
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 54-195;VARIANT TYR-192
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON OCA VARIANTS
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON OCA1 VARIANTS
14.
"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
Basrur V.
,
Yang F.
,
Kushimoto T.
,
Higashimoto Y.
,
Yasumoto K.
,
Valencia J.
,
Muller J.
,
Vieira W.D.
,
Watabe H.
,
Shabanowitz J.
,
Hearing V.J.
,
Hunt D.F.
,
Appella E.
J. Proteome Res.2:69-79(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Melanoma .
15.
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A.
,
Valencia J.C.
,
Hu Z.-Z.
,
Watabe H.
,
Yamaguchi H.
,
Mangini N.J.
,
Huang H.
,
Canfield V.A.
,
Cheng K.C.
,
Yang F.
,
Abe R.
,
Yamagishi S.
,
Shabanowitz J.
,
Hearing V.J.
,
Wu C.
,
Appella E.
,
Hunt D.F.
J. Proteome Res.5:3135-3144(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Melanoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A LYS-373 AND ASN-383;VARIANTS TYR-192 AND GLN-402
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT OCA1A LEU-81
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1B PHE-275 AND LEU-406
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A SER-21; TRP-217; HIS-299; SER-403; SER-446 AND ASN-448
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT OCA1A ARG-89
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT OCA1B GLN-422
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A GLY-42; TYR-55; THR-206 AND ARG-419
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A ILE-176 AND GLN-217
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A GLN-328; ARG-419 AND LEU-431
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A ASP-47; CYS-217 DEL; HIS-299 AND LYS-373;VARIANTS OCA1B SER-152 AND LYS-294
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A TYR-367; THR-370 AND LYS-373;VARIANT GLN-402
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A ARG-361 AND TYR-371
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLN-402
30.
"Novel mutations of the tyrosinase (TYR) gene in type I oculocutaneous albinism (OCA1)."
Spritz R.A.
,
Oh J.
,
Fukai K.
,
Holmes S.A.
,
Ho L.
,
Chitayat D.
,
France T.D.
,
Musarella M.A.
,
Orlow S.J.
,
Schnur R.E.
,
Weleber R.G.
,
Levin A.V.
Hum. Mutat.10:171-174(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A AND OCA1B
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A AND OCA1B
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A TYR-36; GLN-77; TRP-77; LEU-81; ARG-97; GLN-217; TRP-217; SER-236; CYS-272; ARG-289; GLY-294; LYS-294; PRO-355; TYR-371; LYS-373; LEU-406; ARG-419; GLN-422; VAL-439; SER-446 AND ASN-448;VARIANT OCA1B SER-403;VARIANTS TYR-192 AND GLN-402
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A TYR-55; ARG-77 INS; GLY-289; HIS-299; SER-299 AND LEU-400
36.
"Mutation analysis of the tyrosinase gene in oculocutaneous albinism."
Camand O.
,
Marchant D.
,
Boutboul S.
,
Pequignot M.
,
Odent S.
,
Dollfus H.
,
Sutherland J.
,
Levin A.
,
Menasche M.
,
Marsac C.
,
Dufier J.-L.
,
Heon E.
,
Abitbol M.
Hum. Mutat.17:352-352(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A ASP-47; GLN-77; ARG-109; THR-205; TYR-256; PHE-275; LYS-294; GLY-339; PRO-355; LYS-373; ASN-383 AND SER-446
37.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT OCA1A TRP-239
38.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS OCA1A ARG-44; GLY-44; ASP-47; VAL-47; HIS-68; GLN-77; LEU-79; LEU-81; SER-155; PHE-177; LEU-179; ASN-180; ASN-199; SER-201; SER-217; LEU-236; VAL-240; THR-243; TYR-256; ARG-289; GLU-318; PRO-329; THR-332; GLY-345; PRO-355; LYS-373; LYS-378; ASN-383; PHE-393; ARG-395; VAL-398; ALA-398; LEU-402; SER-403; ASN-404; LEU-405; LEU-406; HIS-408; ASP-409; SER-416; HIS-417; ARG-419; GLN-422; PHE-424; LYS-426; GLY-427; ILE-434; ASP-435; GLY-444 AND ASN-448;VARIANTS TYR-192 AND GLN-402
39.
"A genomewide association study of skin pigmentation in a South Asian population."
Stokowski R.P.
,
Pant P.V.K.
,
Dadd T.
,
Fereday A.
,
Hinds D.A.
,
Jarman C.
,
Filsell W.
,
Ginger R.S.
,
Green M.R.
,
van der Ouderaa F.J.
,
Cox D.R.
Am. J. Hum. Genet.81:1119-1132(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT TYR-192;ASSOCIATION WITH SHEP3
40.
"Genetic determinants of hair, eye and skin pigmentation in Europeans."
Sulem P.
,
Gudbjartsson D.F.
,
Stacey S.N.
,
Helgason A.
,
Rafnar T.
,
Magnusson K.P.
,
Manolescu A.
,
Karason A.
,
Palsson A.
,
Thorleifsson G.
,
Jakobsdottir M.
,
Steinberg S.
,
Palsson S.
,
Jonasson F.
,
Sigurgeirsson B.
,
Thorisdottir K.
,
Ragnarsson R.
,
Benediktsdottir K.R.
,
Aben K.K.
,
Kiemeney L.A.
,
Olafsson J.H.
,
Gulcher J.
,
Kong A.
,
Thorsteinsdottir U.
,
Stefansson K.
more...
Nat. Genet.39:1443-1452(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT TYR-192;ASSOCIATION WITH SHEP3
41.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT OCA1A THR-198