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Index > Protein center > UBE2D1(Gene name) > Human
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  • UBE2D1 (Gene name),
  • Ubiquitin-conjugating enzyme E2 D1 (Protein name ),  UB2D1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UBE2D1(SFT;UBC5A;UBCH5;UBCH5A);
    Protein name:
    Ubiquitin-conjugating enzyme E2 D1;
    Alternative:
    UBC4/5 homolog;Stimulator of Fe transport(SFT);Ubiquitin carrier protein D1;UbcH5;Ubiquitin-conjugating enzyme E2-17 kDa 1;Ubiquitin-conjugating enzyme E2(17)KB 1;Ubiquitin-protein ligase D1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with RNF11.
    Function:
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    147
    Sequence:
    50:
    MALKRIQKEL | SDLQRDPPAH | CSAGPVGDDL | FHWQATIMGP | PDSAYQGGVF | 
    100:
    FLTVHFPTDY | PFKPPKIAFT | TKIYHPNINS | NGSICLDILR | SQWSPALTVS | 
    147:
    KVLLSICSLL | CDPNPDDPLV | PDIAQIYKSD | KEKYNRHARE | WTQKYAM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D1
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D1
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D1
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D1
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D1
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D1
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D1
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D1
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D1
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D1
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D1
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D1
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D1
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D1
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D1
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D1
    Protein for Human Ubiquitin-conjugating enzyme E2 D1
    Protein for Human Ubiquitin-conjugating enzyme E2 D1
    Protein for Human Ubiquitin-conjugating enzyme E2 D1
    Protein for Human Ubiquitin-conjugating enzyme E2 D1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53."
      Scheffner M. , Huibregtse J.M. , Howley P.M.
      Proc. Natl. Acad. Sci. U.S.A.91:8797-8801(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis."
      Gehrke S.G. , Riedel H.-D. , Herrmann T. , Hadaschik B. , Bents K. , Veltkamp C. , Stremmel W.
      Blood101:3288-3293(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];TISSUE SPECIFICITY
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skeletal muscle.
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
      tissue: Skin.
    8. 8.
      "Functional expression cloning and characterization of SFT, a stimulator of Fe transport."
      Gutierrez J.A. , Yu J. , Rivera S. , Wessling-Resnick M.
      J. Cell Biol.139:895-905(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 134-147;TISSUE SPECIFICITY
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    10. 10.
      "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses."
      Matsuzawa S. , Reed J.C.
      Mol. Cell7:915-926(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT OF A COMPLEX WITH SIAH1; CACYBP; SKP1; APC AND TBL1X
    11. 11.
      "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase."
      Subramaniam V. , Li H. , Wong M.J. , Kitching R. , Attisano L. , Wrana J. , Zubovits J. , Burger A.M. , Seth A.K.
      Br. J. Cancer89:1538-1544(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF11
    12. 12.
      "Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology."
      Windheim M. , Peggie M. , Cohen P.
      Biochem. J.409:723-729(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide."
      Espinosa A. , Oke V. , Elfving A. , Nyberg F. , Covacu R. , Wahren-Herlenius M.
      Exp. Cell Res.314:3605-3613(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    14. 14.
      "Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor."
      Grou C.P. , Carvalho A.F. , Pinto M.P. , Wiese S. , Piechura H. , Meyer H.E. , Warscheid B. , Sa-Miranda C. , Azevedo J.E.
      J. Biol. Chem.283:14190-14197(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      "CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases."
      Pabarcus M.K. , Hoe N. , Sadeghi S. , Patterson C. , Wiertz E. , Correia M.A.
      Arch. Biochem. Biophys.483:66-74(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      "Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3."
      Zeng W. , Xu M. , Liu S. , Sun L. , Chen Z.J.
      Mol. Cell36:315-325(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."
      David Y. , Ziv T. , Admon A. , Navon A.
      J. Biol. Chem.285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 18.
      "The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor."
      Zhang L. , Fairall L. , Goult B.T. , Calkin A.C. , Hong C. , Millard C.J. , Tontonoz P. , Schwabe J.W.
      Genes Dev.25:1262-1274(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH MYLIP
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