Gene name:
UBE2D2 (UBC4;UBC5B;UBCH4;UBCH5B;UBCH5B) ;
Protein name:
Ubiquitin-conjugating enzyme E2 D2 ;
Alternative:
Ubiquitin-conjugating enzyme E2(17)KB 2 ;Ubiquitin carrier protein D2 ;Ubiquitin-protein ligase D2 ;Ubiquitin-conjugating enzyme E2-17 kDa 2 ;p53-regulated ubiquitin-conjugating enzyme 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex and with E3 ubiquitin-protein ligase PJA2 (By similarity). Interacts with PDZRN3 (By similarity). Interacts with CNOT4 (via RING domain).
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
Subcellular Location:
N/A
Protein Attributes:
50:
MALKRIHKEL | NDLARDPPAQ | CSAGPVGDDM | FHWQATIMGP | NDSPYQGGVF |
100:
FLTIHFPTDY | PFKPPKVAFT | TRIYHPNINS | NGSICLDILR | SQWSPALTIS |
147:
KVLLSICSLL | CDPNPDDPLV | PEIARIYKTD | REKYNRIARE | WTQKYAM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Rat
Human
Pig
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
Protein for Human Ubiquitin-conjugating enzyme E2 D2
Protein for Human Ubiquitin-conjugating enzyme E2 D2
Protein for Human Ubiquitin-conjugating enzyme E2 D2
Protein for Human Ubiquitin-conjugating enzyme E2 D2
Protein for Human Ubiquitin-conjugating enzyme E2 D2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Peripheral blood lymphocyte .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Teratocarcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Testis .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Brain .
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Cajal-Retzius cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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11.
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Oncogene19:3529-3536(2000)
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SCF COMPLEX
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PJA1 AND PJA2
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CNOT4;MUTAGENESIS OF LYS-63
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF CYS-85
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CBLC;MUTAGENESIS OF CYS-85
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS)