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Index > Protein center > UBE2D2(Gene name) > Human
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  • UBE2D2 (Gene name),
  • Ubiquitin-conjugating enzyme E2 D2 (Protein name ),  UB2D2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UBE2D2(UBC4;UBC5B;UBCH4;UBCH5B;UBCH5B);
    Protein name:
    Ubiquitin-conjugating enzyme E2 D2;
    Alternative:
    Ubiquitin-conjugating enzyme E2(17)KB 2;Ubiquitin carrier protein D2;Ubiquitin-protein ligase D2;Ubiquitin-conjugating enzyme E2-17 kDa 2;p53-regulated ubiquitin-conjugating enzyme 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex and with E3 ubiquitin-protein ligase PJA2 (By similarity). Interacts with PDZRN3 (By similarity). Interacts with CNOT4 (via RING domain).
    Function:
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    147
    Sequence:
    50:
    MALKRIHKEL | NDLARDPPAQ | CSAGPVGDDM | FHWQATIMGP | NDSPYQGGVF | 
    100:
    FLTIHFPTDY | PFKPPKVAFT | TRIYHPNINS | NGSICLDILR | SQWSPALTIS | 
    147:
    KVLLSICSLL | CDPNPDDPLV | PEIARIYKTD | REKYNRIARE | WTQKYAM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 D2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 D2
    Protein for Human Ubiquitin-conjugating enzyme E2 D2
    Protein for Human Ubiquitin-conjugating enzyme E2 D2
    Protein for Human Ubiquitin-conjugating enzyme E2 D2
    Protein for Human Ubiquitin-conjugating enzyme E2 D2
    Protein for Human Ubiquitin-conjugating enzyme E2 D2

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    References
    1. 1.
      "Identification of a family of closely related human ubiquitin conjugating enzymes."
      Jensen J.P. , Bates P.W. , Yang M. , Vierstra R.D. , Weissman A.M.
      J. Biol. Chem.270:30408-30414(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Peripheral blood lymphocyte.
    2. 2.
      "Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)."
      Rolfe M. , Beer-Romero P. , Glass S. , Eckstein J. , Berdo I. , Theodoras A. , Pagano M. , Draetta G.
      Proc. Natl. Acad. Sci. U.S.A.92:3264-3268(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia."
      Guinn B.-A. , Bland E.A. , Lodi U. , Liggins A.P. , Tobal K. , Petters S. , Wells J.W. , Banham A.H. , Mufti G.J.
      Biochem. Biophys. Res. Commun.335:1293-1304(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Testis.
    4. 4.
      "Cloning and identification of a p53-regulated ubiquitin-conjugating enzyme, PUBC1."
      Yin Y.
      Submitted (2000-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Teratocarcinoma.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    8. 9.
      Lubec G. , Afjehi-Sadat L.
      Submitted (2007-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 73-90;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
    9. 10.
      "Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha."
      Gonen H. , Bercovich B. , Orian A. , Carrano A. , Takizawa C. , Yamanaka K. , Pagano M. , Iwai K. , Ciechanover A.
      J. Biol. Chem.274:14823-14830(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-85
    10. 11.
      "SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4."
      Strack P. , Caligiuri M. , Pelletier M. , Boisclair M. , Theodoras A. , Beer-Romero P. , Glass S. , Parsons T. , Copeland R.A. , Auger K.R. , Benfield P. , Brizuela L. , Rolfe M.
      Oncogene19:3529-3536(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCF COMPLEX
    11. 12.
      "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain."
      Yu P. , Chen Y. , Tagle D.A. , Cai T.
      Genomics79:869-874(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PJA1 AND PJA2
    12. 13.
      "Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo."
      Saville M.K. , Sparks A. , Xirodimas D.P. , Wardrop J. , Stevenson L.F. , Bourdon J.C. , Woods Y.L. , Lane D.P.
      J. Biol. Chem.279:42169-42181(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 14.
      "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair."
      Winkler G.S. , Albert T.K. , Dominguez C. , Legtenberg Y.I. , Boelens R. , Timmers H.T.
      J. Mol. Biol.337:157-165(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CNOT4;MUTAGENESIS OF LYS-63
    14. 15.
      "Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology."
      Windheim M. , Peggie M. , Cohen P.
      Biochem. J.409:723-729(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 16.
      "Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation."
      Chiang M.H. , Chen L.F. , Chen H.
      Biol. Reprod.79:914-920(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-85
    16. 17.
      "Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor."
      Grou C.P. , Carvalho A.F. , Pinto M.P. , Wiese S. , Piechura H. , Meyer H.E. , Warscheid B. , Sa-Miranda C. , Azevedo J.E.
      J. Biol. Chem.283:14190-14197(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 18.
      "Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3."
      Zeng W. , Xu M. , Liu S. , Sun L. , Chen Z.J.
      Mol. Cell36:315-325(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION
    18. 19.
      "Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity."
      Zeng W. , Sun L. , Jiang X. , Chen X. , Hou F. , Adhikari A. , Xu M. , Chen Z.J.
      Cell141:315-330(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    19. 20.
      "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."
      David Y. , Ziv T. , Admon A. , Navon A.
      J. Biol. Chem.285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    20. 21.
      "The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme."
      Ryan P.E. , Sivadasan-Nair N. , Nau M.M. , Nicholas S. , Lipkowitz S.
      J. Biol. Chem.285:23687-23698(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CBLC;MUTAGENESIS OF CYS-85
    21. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 23.
      "Solution structure of the ubiquitin-conjugating enzyme UbcH5B."
      Houben K. , Dominguez C. , van Schaik F.M. , Timmers H.T. , Bonvin A.M. , Boelens R.
      J. Mol. Biol.344:513-526(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    23. 24.
      "Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates."
      Sakata E. , Satoh T. , Yamamoto S. , Yamaguchi Y. , Yagi-Utsumi M. , Kurimoto E. , Tanaka K. , Wakatsuki S. , Kato K.
      Structure18:138-147(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS)
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