Ube2n ELISA Kit for Rat(Rattus norvegicus) | EIAab.comUbe2n ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Ube2n(Gene name) > Rat

Ube2n (Gene name),

Ubiquitin-conjugating enzyme E2 N (Protein name ), UBE2N_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ube2n;

Protein name:

Ubiquitin-conjugating enzyme E2 N;

Alternative:

Ubiquitin carrier protein N;Bendless-like ubiquitin-conjugating enzyme;Ubiquitin-protein ligase N;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterodimer with UBE2V2. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with RNF8 and RNF168. Interacts with RNF11. Interacts with the E3 ligases, HLTF and SHPRH; the interactions promote the 'Lys-63'-linked polyubiquitination of PCNA upon genotoxic stress and lead to DNA repair. Interacts with ARIH2 (via RING-type 2).

Function:

The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

152

Sequence:

50:

100:

150:

152:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9EQX9

KEGG:

rno:116725

Pfam:

PF00179

UniGene:

Rn.230134

SMR:

Q9EQX9

STRING:

10116.ENSRNOP00000055805

UniGene:

Rn.165094

Uniprot:

Q9EQX9

FOR

ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 N

CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 N

Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 N

Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 N

Protein for Rat Ubiquitin-conjugating enzyme E2 N

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression of rat Bendless gene in the developing brain."
Takahashi H. , Yamamoto M. , Saito Y.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.
3.

Lubec G. , Afjehi-Sadat L. , Diao W.
Submitted (2007-04) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-68;IDENTIFICATION BY MASS SPECTROMETRY
strain: Sprague-Dawley.
tissue: Hippocampus.
tissue: Spinal cord.
4.

Maurya D.K. , Bhargava P.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY

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