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Index > Protein center > UBE4B(Gene name) > Human
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  • UBE4B (Gene name),
  • Ubiquitin conjugation factor E4 B (Protein name ),  UBE4B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    UBE4B(HDNB1;KIAA0684;UFD2);
    Protein name:
    Ubiquitin conjugation factor E4 B;
    Alternative:
    Ubiquitin fusion degradation protein 2;Homozygously deleted in neuroblastoma 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with VCP.
    Function:
    Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    1302
    Sequence:
    50:
    MEELSADEIR | RRRLARLAGG | QTSQPTTPLT | SPQRENPPGP | PIAASAPGPS | 
    100:
    QSLGLNVHNM | TPATSPIGAS | GVAHRSQSSE | GVSSLSSSPS | NSLETQSQSL | 
    150:
    SRSQSMDIDG | VSCEKSMSQV | DVDSGIENME | VDENDRREKR | SLSDKEPSSG | 
    200:
    PEVSEEQALQ | LVCKIFRVSW | KDRDRDVIFL | SSLSAQFKQN | PKEVFSDFKD | 
    250:
    LIGQILMEVL | MMSTQTRDEN | PFASLTATSQ | PIAAAARSPD | RNLLLNTGSN | 
    300:
    PGTSPMFCSV | ASFGASSLSS | LYESSPAPTP | SFWSSVPVMG | PSLASPSRAA | 
    350:
    SQLAVPSTPL | SPHSAASGTA | AGSQPSSPRY | RPYTVTHPWA | SSGVSILSSS | 
    400:
    PSPPALASSP | QAVPASSSRQ | RPSSTGPPLP | PASPSATSRR | PSSLRISPSL | 
    450:
    GASGGASNWD | SYSDHFTIET | CKETDMLNYL | IECFDRVGIE | EKKAPKMCSQ | 
    500:
    PAVSQLLSNI | RSQCISHTAL | VLQGSLTQPR | SLQQPSFLVP | YMLCRNLPYG | 
    550:
    FIQELVRTTH | QDEEVFKQIF | IPILQGLALA | AKECSLDSDY | FKYPLMALGE | 
    600:
    LCETKFGKTH | PVCNLVASLR | LWLPKSLSPG | CGRELQRLSY | LGAFFSFSVF | 
    650:
    AEDDVKVVEK | YFSGPAITLE | NTRVVSQSLQ | HYLELGRQEL | FKILHSILLN | 
    700:
    GETREAALSY | MAAVVNANMK | KAQMQTDDRL | VSTDGFMLNF | LWVLQQLSTK | 
    750:
    IKLETVDPTY | IFHPRCRITL | PNDETRVNAT | MEDVNDWLTE | LYGDQPPFSE | 
    800:
    PKFPTECFFL | TLHAHHLSIL | PSCRRYIRRL | RAIRELNRTV | EDLKNNESQW | 
    850:
    KDSPLATRHR | EMLKRCKTQL | KKLVRCKACA | DAGLLDESFL | RRCLNFYGLL | 
    900:
    IQLLLRILDP | AYPDITLPLN | SDVPKVFAAL | PEFYVEDVAE | FLFFIVQYSP | 
    950:
    QALYEPCTQD | IVMFLVVMLC | NQNYIRNPYL | VAKLVEVMFM | TNPAVQPRTQ | 
    1000:
    KFFEMIENHP | LSTKLLVPSL | MKFYTDVEHT | GATSEFYDKF | TIRYHISTIF | 
    1050:
    KSLWQNIAHH | GTFMEEFNSG | KQFVRYINML | INDTTFLLDE | SLESLKRIHE | 
    1100:
    VQEEMKNKEQ | WDQLPRDQQQ | ARQSQLAQDE | RVSRSYLALA | TETVDMFHIL | 
    1150:
    TKQVQKPFLR | PELGPRLAAM | LNFNLQQLCG | PKCRDLKVEN | PEKYGFEPKK | 
    1200:
    LLDQLTDIYL | QLDCARFAKA | IADDQRSYSK | ELFEEVISKM | RKAGIKSTIA | 
    1250:
    IEKFKLLAEK | VEEIVAKNAR | AEIDYSDAPD | EFRDPLMDTL | MTDPVRLPSG | 
    1300:
    TIMDRSIILR | HLLNSPTDPF | NRQTLTESML | EPVPELKEQI | QAWMREKQNS | 
    1302:
    DH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    Pfam:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin conjugation factor E4 B
    ELISA Kit for Human Ubiquitin conjugation factor E4 B
    CLIA Kit for Human Ubiquitin conjugation factor E4 B
    CLIA Kit for Human Ubiquitin conjugation factor E4 B
    Polyclonal Antibody for Human Ubiquitin conjugation factor E4 B
    Polyclonal Antibody for Human Ubiquitin conjugation factor E4 B
    Monoclonal Antibody for Human Ubiquitin conjugation factor E4 B
    Monoclonal Antibody for Human Ubiquitin conjugation factor E4 B
    Protein for Human Ubiquitin conjugation factor E4 B
    Protein for Human Ubiquitin conjugation factor E4 B

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and expression analysis of five novel genes in chromosome 1p36."
      Onyango P. , Lubyova B. , Gardellin P. , Kurzbauer R. , Weith A.
      Genomics50:187-198(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line."
      Ohira M. , Kageyama H. , Mihara M. , Furuta S. , Machida T. , Shishikura T. , Takayasu H. , Islam A. , Nakamura Y. , Takahashi M. , Tomioka N. , Sakiyama S. , Kaneko Y. , Toyoda A. , Hattori M. , Sakaki Y. , Ohki M. , Horii A. , more...
      Oncogene19:4302-4307(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Substantia nigra.
    3. 3.
      "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis."
      Mahoney J.A. , Odin J.A. , White S.M. , Shaffer D. , Koff A. , Casciola-Rosen L. , Rosen A.
      Biochem. J.361:587-595(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;MUTAGENESIS OF ASP-109; ASP-121 AND ASP-123;CLEAVAGE BY CASPASES
    4. 4.
      "A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells."
      Mammen A.L. , Mahoney J.A. , St Germain A. , Badders N. , Taylor J.P. , Rosen A. , Spinette S.
      PLoS ONE6:E28861-E28861(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);ALTERNATIVE SPLICING
      tissue: Skeletal muscle.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K. , Nagase T. , Suyama M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    6. 6.
      Ohara O. , Suyama M. , Nagase T. , Ishikawa K.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    8. 8.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Cerebellum.
    10. 10.
      "Full-insert sequence of mapped XREF EST."
      Barrow I.K.-P. , Boguski M.S. , Touchman J.W. , Spencer F.
      Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1112-1302
    11. 11.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-88; SER-90; SER-101 AND SER-803;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-88; SER-90 AND SER-101;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    18. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803 AND SER-1265;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103 AND SER-803;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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