UBIAD1 ELISA Kit for Human(Homo sapiens) | EIAab.comUBIAD1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > UBIAD1(Gene name) > Human

UBIAD1 (Gene name),

UbiA prenyltransferase domain-containing protein 1 (Protein name ), UBIA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UBIAD1(TERE1);

Protein name:

UbiA prenyltransferase domain-containing protein 1;

Alternative:

Transitional epithelial response protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas. Mediates the conversion of phylloquinone (PK) into menaquinone-4 (MK-4), probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein Cytoplasm Nucleus Mitochondrion

Protein Attributes:

Sequence length:

338

Sequence:

50:

100:

150:

200:

250:

300:

338:

RSQAFNKLPQ | RTAKLNLLLG | LFYVFGIILA | PAGSLPKI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01040

KEGG:

hsa:29914

String:

Q9Y5Z9

UniGene:

Hs.522933

MIM:

121800

STRING:

9606.ENSP00000366006

Uniprot:

Q9Y5Z9

FOR

ELISA Kit for Human UbiA prenyltransferase domain-containing protein 1

CLIA Kit for Human UbiA prenyltransferase domain-containing protein 1

Polyclonal Antibody for Human UbiA prenyltransferase domain-containing protein 1

Monoclonal Antibody for Human UbiA prenyltransferase domain-containing protein 1

Protein for Human UbiA prenyltransferase domain-containing protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation and characterization of the TERE1 gene, a gene down-regulated in transitional cell carcinoma of the bladder."
McGarvey T.W. , Nguyen T. , Tomaszewski J.E. , Monson F.C. , Malkowicz S.B.
Oncogene20:1042-1051(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
tissue: Spleen.
2.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
3.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Liver.
4.

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
8.

"TERE1, a novel gene affecting growth regulation in prostate carcinoma."
McGarvey T.W. , Nguyen T. , Puthiyaveettil R. , Tomaszewski J.E. , Malkowicz S.B.
Prostate54:144-155(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CARCINOMA;SUBCELLULAR LOCATION
9.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
10.

"Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme."
Nakagawa K. , Hirota Y. , Sawada N. , Yuge N. , Watanabe M. , Uchino Y. , Okuda N. , Shimomura Y. , Suhara Y. , Okano T.
Nature468:117-121(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PATHWAY;SUBCELLULAR LOCATION
11.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis."
Mugoni V. , Postel R. , Catanzaro V. , De Luca E. , Turco E. , Digilio G. , Silengo L. , Murphy M.P. , Medana C. , Stainier D.Y. , Bakkers J. , Santoro M.M.
Cell152:504-518(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANTS SCCD SER-102 AND GLY-112
13.

"Mutations in the UBIAD1 gene on chromosome short arm 1, region 36, cause Schnyder crystalline corneal dystrophy."
Weiss J.S. , Kruth H.S. , Kuivaniemi H. , Tromp G. , White P.S. , Winters R.S. , Lisch W. , Henn W. , Denninger E. , Krause M. , Wasson P. , Ebenezer N. , Mahurkar S. , Nickerson M.L.
Invest. Ophthalmol. Vis. Sci.48:5007-5012(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCCD SER-102 AND ARG-177
14.

"Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy."
Orr A. , Dube M.-P. , Marcadier J. , Jiang H. , Federico A. , George S. , Seamone C. , Andrews D. , Dubord P. , Holland S. , Provost S. , Mongrain V. , Evans S. , Higgins B. , Bowman S. , Guernsey D. , Samuels M.
PLoS ONE2:E685-E685(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCCD SER-102; GLY-112; GLY-119; ILE-175 AND SER-232;VARIANT PHE-75
15.

"Genetic analysis of 14 families with Schnyder crystalline corneal dystrophy reveals clues to UBIAD1 protein function."
Weiss J.S. , Kruth H.S. , Kuivaniemi H. , Tromp G. , Karkera J. , Mahurkar S. , Lisch W. , Dupps W.J. Jr. , White P.S. , Winters R.S. , Kim C. , Rapuano C.J. , Sutphin J. , Reidy J. , Hu F.-R. , Lu da W. , Ebenezer N. , Nickerson M.L.
Am. J. Med. Genet. A146:271-283(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCCD SER-102; GLY-118; PHE-121; PRO-171; ILE-175; ARG-177; ARG-186 AND GLU-236
16.

"Surgical management and genetic analysis of a Chinese family with the S171P mutation in the UBIAD1 gene, the gene for Schnyder corneal dystrophy."
Mehta J.S. , Vithana E.N. , Venkataraman D. , Venkatraman A. , Yong V.H. , Aung T. , Tan D.T.
Br. J. Ophthalmol.93:926-931(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCCD PRO-171
17.

"A novel UBIAD1 mutation identified in a Chinese family with Schnyder crystalline corneal dystrophy."
Jing Y. , Liu C. , Xu J. , Wang L.
Mol. Vis.15:1463-1469(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCCD SER-98
18.

"Newly reported p.Asp240Asn mutation in UBIAD1 suggests central discoid corneal dystrophy is a variant of Schnyder corneal dystrophy."
Weiss J.S. , Wiaux C. , Yellore V. , Raber I. , Eagle R. , Mequio M. , Aldave A.
Cornea29:777-780(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCCD ASN-240
19.

"UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy."
Nickerson M.L. , Kostiha B.N. , Brandt W. , Fredericks W. , Xu K.P. , Yu F.S. , Gold B. , Chodosh J. , Goldberg M. , Lu da W. , Yamada M. , Tervo T.M. , Grutzmacher R. , Croasdale C. , Hoeltzenbein M. , Sutphin J. , Malkowicz S.B. , Wessjohann L. , more...
PLoS ONE5:E10760-E10760(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCCD THR-97; SER-102; ASN-112; GLY-122; GLU-122 AND HIS-188;SUBCELLULAR LOCATION
20.

"The UBIAD1 prenyltransferase links menaquione-4 synthesis to cholesterol metabolic enzymes."
Nickerson M.L. , Bosley A.D. , Weiss J.S. , Kostiha B.N. , Hirota Y. , Brandt W. , Esposito D. , Kinoshita S. , Wessjohann L. , Morham S.G. , Andresson T. , Kruth H.S. , Okano T. , Dean M.
Hum. Mutat.34:317-329(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLU-177;CHARACTERIZATION OF VARIANTS SCCD SER-102; ASN-112; GLU-177 AND ARG-177;INTERACTION WITH HMGCR AND SOAT1

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