Protein name:
Ubiquitin carboxyl-terminal hydrolase 14 ;
Alternative:
Ubiquitin thiolesterase 14 ;Deubiquitinating enzyme 14 ;Ubiquitin-specific-processing protease 14 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer (Potential). Interacts with FANCC, CXCR4 and ERN1 (By similarity). Associates with the 26S proteasome.
Function:
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Maintains the cellular levels of monomeric ubiquitin in cells. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor cxcr4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1.
Subcellular Location:
Cytoplasm
Cell membrane
Peripheral membrane protein
Protein Attributes:
50:
MPLYSVTVKW | GKEKFEGVEL | NTDEPPMVFK | AQLFALTGVQ | PARQKVMVKG |
100:
GTLKDDDWGN | IKMKNGMTVL | MMGSADALPE | EPSAKTVFVE | DMTEEQLATA |
150:
MELPCGLTNL | GNTCYMNATV | QCIRSVPELK | DALKRYAGAL | RASGEMASAQ |
200:
YITAALRDLF | DSMDKTSSSI | PPIILLQFLH | MAFPQFAEKG | EQGQYLQQDA |
250:
NECWIQMMRV | LQQKLEAIED | DSGRETDSSS | APAVTPSKKK | SLIDQYFGVE |
300:
FETTMKCTES | EEEEVTKGKE | NQLQLSCFIN | QEVKYLFTGL | KLRLQEEITK |
350:
QSPTLQRNAL | YIKSSKISRL | PAYLTIQMVR | FFYKEKESVN | AKVLKDVKFP |
400:
LMLDVYELCT | PELQEKMVSF | RSKFKDLEDK | KVNQQPNAND | KNSPPKEIKY |
450:
EPFSFADDIG | SNNCGYYDLQ | AVLTHQGRSS | SSGHYVSWVR | RKQDEWIKFD |
493:
DDKVSIVTPE | DILRLSGGGD | WHIAYVLLYG | PRRVEIMEEE | SEQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rabbit
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 14
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 14
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Mouse deubiquitinating enzyme-type TGT."
Hidaka T.
,
Morishita T.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .
2.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Corpora quadrigemina .
tissue :
Embryo .
tissue :
Testis .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION;ASSOCIATION WITH THE 26S PROTEASOME
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ASSOCIATION WITH THE 26S PROTEASOME
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 4-86