Protein name:
Ubiquitin carboxyl-terminal hydrolase 14 ;
Alternative:
Ubiquitin thiolesterase 14 ;Deubiquitinating enzyme 14 ;Ubiquitin-specific-processing protease 14 ;
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Sub Unit:
Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1.
Function:
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Subcellular Location:
Cytoplasm
Cell membrane
Peripheral membrane protein
Protein Attributes:
50:
MPLYSVTVKW | GKEKFGGVEL | NTDEPPMVFK | AQLFALTGVQ | PARQRVMVKG |
100:
GTLKDDDWGN | IKIKNGMTIL | MMGSADALPE | EPSAKTVFVE | DMTEEQLASA |
150:
MELPCGLTNL | GNTCYMNATV | QCIRSVPELK | DALKRYAGAL | RASGEMASAQ |
200:
YITAALRDLF | DSMDKTSSSI | PPIILLQFLH | MAFPQFAEKG | EQGQYLQQDA |
250:
NECWIQMMRV | LQQKLEAIED | DSVKETDSSA | AAVAPSKKKS | LIDQFFGVEF |
300:
ETTMKCTESE | EEEVTKGKEN | QLQLSCFINQ | EVKYLFTGLK | LRLQEEITKQ |
350:
SPTLQRNALY | IKSSKISRLP | AYLTIQMVRF | FYKEKESVNA | KVLKDVKFPL |
400:
MLDVYELCTP | ELQEKMVSFR | SKFKDIEDKK | VNQQPNASDK | KSSPQKEVRY |
450:
EPFSFADDIG | SNNCGYYDLQ | AVLTHQGRSS | SSGHYVSWVK | RKHDEWIKFD |
493:
DDKVSIVTPE | DILRLSGGGD | WHIAYVLLYG | PRRVEIMEEE | NEQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rabbit
ELISA Kit for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Protein for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Protein for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Protein for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
Protein for Rabbit Ubiquitin carboxyl-terminal hydrolase 14
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
strain :
New Zealand white .
tissue :
Liver .