USP15 ELISA Kit for Human(Homo sapiens) | EIAab.comUSP15 ELISA Kit for Human(Homo sapiens)

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USP15 (Gene name),

Ubiquitin carboxyl-terminal hydrolase 15 (Protein name ), UBP15_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

USP15(KIAA0529);

Protein name:

Ubiquitin carboxyl-terminal hydrolase 15;

Alternative:

Ubiquitin thiolesterase 15;Deubiquitinating enzyme 15;Unph-2;Ubiquitin-specific-processing protease 15;Unph4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Identified in a complex with the COP9 signalosome complex (CSN). Interacts with human papillomavirus type 16 protein E6.

Function:

Protease that degrades 'Lys-48'-linked polyubiquitin chains. Protects target proteins against proteasomal degradation. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

981

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

981:

ASAATGIPLE | SDEDSNDNDN | DIENENCMHT | N

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9Y4E8

UniGene:

Hs.434951

Pfam:

PF06337

STRING:

9606.ENSP00000258123

SMR:

Q9Y4E8

KEGG:

hsa:9958

MIM:

604731

Uniprot:

Q9Y4E8

FOR

ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 15

CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 15

Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 15

Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 15

Protein for Human Ubiquitin carboxyl-terminal hydrolase 15

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification and characterization of a new human deubiquitinating enzyme Unph4."
Kim K.I. , Nagase T. , Chung C.H.
Submitted (1998-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Brain.
2.

"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
3.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
4.

"A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags."
Kim M.K. , Kim Y.H. , Seo J.M. , Lee H.M. , Chung H.J. , Sohn M.Y. , Hwang S.Y. , Im S.U. , Jung E.J. , Lee J.H. , Kim J.C.
Submitted (1999-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Hair follicle dermal papilla.
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Placenta.
6.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4)
tissue: Brain.
tissue: Lung.
8.

Bienvenut W.V. , Matallanas D. , Cooper W.N. , Kolch W.
Submitted (2007-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21; 475-482 AND 924-932;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Mammary carcinoma.
9.

"Cloning and identification of human Unph-2."
Kimura Y. , Saya H. , Nakao M.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-981 (ISOFORM 3)
tissue: Fetal brain.
10.

"Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases."
Baker R.T. , Wang X.-W. , Woollatt E. , White J.A. , Sutherland G.R.
Genomics59:264-274(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION (ISOFORM 2);CATALYTIC ACTIVITY
11.

"Isolation and characterization of the mouse ubiquitin-specific protease Usp15."
Angelats C. , Wang X.-W. , Jermiin L.S. , Copeland N.G. , Jenkins N.A. , Baker R.T.
Mamm. Genome14:31-46(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
12.

"The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1."
Hetfeld B.K. , Helfrich A. , Kapelari B. , Scheel H. , Hofmann K. , Guterman A. , Glickman M. , Schade R. , Kloetzel P.M. , Dubiel W.
Curr. Biol.15:1217-1221(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF CYS-812;IDENTIFICATION IN A COMPLEX WITH THE COP9 SIGNALOSOME;PHOSPHORYLATION;UBIQUITINATION
13.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha."
Schweitzer K. , Bozko P.M. , Dubiel W. , Naumann M.
EMBO J.26:1532-1541(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; SER-961 AND SER-965;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP."
Cayli S. , Klug J. , Chapiro J. , Frohlich S. , Krasteva G. , Orel L. , Meinhardt A.
J. Biol. Chem.284:34944-34953(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15."
Huang X. , Langelotz C. , Hetfeld-Pechoc B.K. , Schwenk W. , Dubiel W.
J. Mol. Biol.391:691-702(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-812
19.

"The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability."
Vos R.M. , Altreuter J. , White E.A. , Howley P.M.
J. Virol.83:8885-8892(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-298;INTERACTION WITH HUMAN PAPILLOMAVIRUS TYPE 16 PROTEIN E6
20.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
21.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; SER-242; SER-961 AND SER-965;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"USP15 is a deubiquitylating enzyme for receptor-activated SMADs."
Inui M. , Manfrin A. , Mamidi A. , Martello G. , Morsut L. , Soligo S. , Enzo E. , Moro S. , Polo S. , Dupont S. , Cordenonsi M. , Piccolo S.
Nat. Cell Biol.13:1368-1375(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;INTERACTION WITH SMAD1; SMAD2 AND SMAD3;MUTAGENESIS OF CYS-298
24.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma."
Eichhorn P.J. , Rodon L. , Gonzalez-Junca A. , Dirac A. , Gili M. , Martinez-Saez E. , Aura C. , Barba I. , Peg V. , Prat A. , Cuartas I. , Jimenez J. , Garcia-Dorado D. , Sahuquillo J. , Bernards R. , Baselga J. , Seoane J.
Nat. Med.18:429-435(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH TGFBR1 AND SMAD7;MUTAGENESIS OF CYS-298
27.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.

"The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination."
Long L. , Thelen J.P. , Furgason M. , Haj-Yahya M. , Brik A. , Cheng D. , Peng J. , Yao T.
J. Biol. Chem.289:8916-8930(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RNF20; RNF40 AND SART3;REGION;SUBCELLULAR LOCATION
29.

"Solution structure of the human ubiquitin-specific protease 15 DUSP domain."
de Jong R.N. , Ab E. , Diercks T. , Truffault V. , Danieels M. , Kaptein R. , Folkers G.E.
J. Biol. Chem.281:5026-5031(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-120
30.

"Structure of the USP15 N-terminal domains: a beta-hairpin mediates close association between the DUSP and UBL domains."
Harper S. , Besong T.M. , Emsley J. , Scott D.J. , Dreveny I.
Biochemistry50:7995-8004(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1-222
31.

"Structural variability of the ubiquitin specific protease DUSP-UBL double domains."
Elliott P.R. , Liu H. , Pastok M.W. , Grossmann G.J. , Rigden D.J. , Clague M.J. , Urbe S. , Barsukov I.L.
FEBS Lett.585:3385-3390(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 1-223
32.

"Crystal structure of the human ubiquitin-specific protease 15 DUSP domain."
Structural genomics consortium (SGC)
Submitted (2010-04) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 1-133

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