Usp22 ELISA Kit for Mouse(Mus musculus) | EIAab.comUsp22 ELISA Kit for Mouse(Mus musculus)

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Usp22 (Gene name),

Ubiquitin carboxyl-terminal hydrolase 22 (Protein name ), UBP22_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Usp22(Kiaa1063);

Protein name:

Ubiquitin carboxyl-terminal hydrolase 22;

Alternative:

Ubiquitin thiolesterase 22;Deubiquitinating enzyme 22;Ubiquitin-specific-processing protease 22;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitinylation. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex.

Function:

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

525

Sequence:

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