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Index > Protein center > USP33(Gene name) > Human
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  • USP33 (Gene name),
  • Ubiquitin carboxyl-terminal hydrolase 33 (Protein name ),  UBP33_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    USP33(KIAA1097;VDU1);
    Protein name:
    Ubiquitin carboxyl-terminal hydrolase 33;
    Alternative:
    Ubiquitin thiolesterase 33;Deubiquitinating enzyme 33;VHL-interacting deubiquitinating enzyme 1(hVDU1);Ubiquitin-specific-processing protease 33;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with ARRB1, ARRB2, ADRB2, DIO2 and ROBO1. Interacts with SELENBP1; in a selenium-dependent manner.
    Function:
    Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
    Subcellular Location:
    Cytoplasm perinuclear region According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
    Protein Attributes:
    Sequence length:
    942
    Sequence:
    50:
    MTGSNSHITI | LTLKVLPHFE | SLGKQEKIPN | KMSAFRNHCP | HLDSVGEITK | 
    100:
    EDLIQKSLGT | CQDCKVQGPN | LWACLENRCS | YVGCGESQVD | HSTIHSQETK | 
    150:
    HYLTVNLTTL | RVWCYACSKE | VFLDRKLGTQ | PSLPHVRQPH | QIQENSVQDF | 
    200:
    KIPSNTTLKT | PLVAVFDDLD | IEADEEDELR | ARGLTGLKNI | GNTCYMNAAL | 
    250:
    QALSNCPPLT | QFFLDCGGLA | RTDKKPAICK | SYLKLMTELW | HKSRPGSVVP | 
    300:
    TTLFQGIKTV | NPTFRGYSQQ | DAQEFLRCLM | DLLHEELKEQ | VMEVEEDPQT | 
    350:
    ITTEETMEED | KSQSDVDFQS | CESCSNSDRA | ENENGSRCFS | EDNNETTMLI | 
    400:
    QDDENNSEMS | KDWQKEKMCN | KINKVNSEGE | FDKDRDSISE | TVDLNNQETV | 
    450:
    KVQIHSRASE | YITDVHSNDL | STPQILPSNE | GVNPRLSASP | PKSGNLWPGL | 
    500:
    APPHKKAQSA | SPKRKKQHKK | YRSVISDIFD | GTIISSVQCL | TCDRVSVTLE | 
    550:
    TFQDLSLPIP | GKEDLAKLHS | SSHPTSIVKA | GSCGEAYAPQ | GWIAFFMEYV | 
    600:
    KRFVVSCVPS | WFWGPVVTLQ | DCLAAFFARD | ELKGDNMYSC | EKCKKLRNGV | 
    650:
    KFCKVQNFPE | ILCIHLKRFR | HELMFSTKIS | THVSFPLEGL | DLQPFLAKDS | 
    700:
    PAQIVTYDLL | SVICHHGTAS | SGHYIAYCRN | NLNNLWYEFD | DQSVTEVSES | 
    750:
    TVQNAEAYVL | FYRKSSEEAQ | KERRRISNLL | NIMEPSLLQF | YISRQWLNKF | 
    800:
    KTFAEPGPIS | NNDFLCIHGG | VPPRKAGYIE | DLVLMLPQNI | WDNLYSRYGG | 
    850:
    GPAVNHLYIC | HTCQIEAEKI | EKRRKTELEI | FIRLNRAFQK | EDSPATFYCI | 
    900:
    SMQWFREWES | FVKGKDGDPP | GPIDNTKIAV | TKCGNVMLRQ | GADSGQISEE | 
    942:
    TWNFLQSIYG | GGPEVILRPP | VVHVDPDILQ | AEEKIEVETR | SL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    UniGene:
    SMR:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 33
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 33
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 33

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein."
      Li Z. , Na X. , Wang D. , Schoen S.R. , Messing E.M. , Wu G.
      J. Biol. Chem.277:4656-4662(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);UBIQUITINATION;INTERACTION WITH VHL;TISSUE SPECIFICITY
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R. , Nagase T. , Ishikawa K. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Eye.
    6. 6.
      "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation."
      Curcio-Morelli C. , Zavacki A.M. , Christofollete M. , Gereben B. , de Freitas B.C. , Harney J.W. , Li Z. , Wu G. , Bianco A.C.
      J. Clin. Invest.112:189-196(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DIO2
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner."
      Jeong J.Y. , Wang Y. , Sytkowski A.J.
      Biochem. Biophys. Res. Commun.379:583-588(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELENBP1;SUBCELLULAR LOCATION
    9. 9.
      "The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization."
      Berthouze M. , Venkataramanan V. , Li Y. , Shenoy S.K.
      EMBO J.28:1684-1696(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ADRB2;MUTAGENESIS OF CYS-194 AND HIS-673
    10. 10.
      "Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2."
      Shenoy S.K. , Modi A.S. , Shukla A.K. , Xiao K. , Berthouze M. , Ahn S. , Wilkinson K.D. , Miller W.E. , Lefkowitz R.J.
      Proc. Natl. Acad. Sci. U.S.A.106:6650-6655(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ARRB1 AND ARRB2;MUTAGENESIS OF CYS-194 AND HIS-673
    11. 11.
      "Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatus."
      Thorne C. , Eccles R.L. , Coulson J.M. , Urbe S. , Clague M.J.
      Traffic12:1563-1574(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 3);SUBCELLULAR LOCATION
    12. 12.
      "USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110."
      Li J. , D'Angiolella V. , Seeley E.S. , Kim S. , Kobayashi T. , Fu W. , Campos E.I. , Pagano M. , Dynlacht B.D.
      Nature495:255-259(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CCP110;DEVELOPMENTAL STAGE;MUTAGENESIS OF CYS-194 AND HIS-673
    13. 13.
      "The solution structure of the ZnF UBP domain of USP33/VDU1."
      Allen M.D. , Bycroft M.
      Protein Sci.16:2072-2075(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 36-130;ZINC-BINDING;DOMAIN UBP-TYPE ZINC FINGER
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