Gene name:
USP33 (KIAA1097;VDU1) ;
Protein name:
Ubiquitin carboxyl-terminal hydrolase 33 ;
Alternative:
Ubiquitin thiolesterase 33 ;Deubiquitinating enzyme 33 ;VHL-interacting deubiquitinating enzyme 1 (hVDU1) ;Ubiquitin-specific-processing protease 33 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with ARRB1, ARRB2, ADRB2, DIO2 and ROBO1. Interacts with SELENBP1; in a selenium-dependent manner.
Function:
Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
Subcellular Location:
Cytoplasm
perinuclear region
According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
Protein Attributes:
50:
MTGSNSHITI | LTLKVLPHFE | SLGKQEKIPN | KMSAFRNHCP | HLDSVGEITK |
100:
EDLIQKSLGT | CQDCKVQGPN | LWACLENRCS | YVGCGESQVD | HSTIHSQETK |
150:
HYLTVNLTTL | RVWCYACSKE | VFLDRKLGTQ | PSLPHVRQPH | QIQENSVQDF |
200:
KIPSNTTLKT | PLVAVFDDLD | IEADEEDELR | ARGLTGLKNI | GNTCYMNAAL |
250:
QALSNCPPLT | QFFLDCGGLA | RTDKKPAICK | SYLKLMTELW | HKSRPGSVVP |
300:
TTLFQGIKTV | NPTFRGYSQQ | DAQEFLRCLM | DLLHEELKEQ | VMEVEEDPQT |
350:
ITTEETMEED | KSQSDVDFQS | CESCSNSDRA | ENENGSRCFS | EDNNETTMLI |
400:
QDDENNSEMS | KDWQKEKMCN | KINKVNSEGE | FDKDRDSISE | TVDLNNQETV |
450:
KVQIHSRASE | YITDVHSNDL | STPQILPSNE | GVNPRLSASP | PKSGNLWPGL |
500:
APPHKKAQSA | SPKRKKQHKK | YRSVISDIFD | GTIISSVQCL | TCDRVSVTLE |
550:
TFQDLSLPIP | GKEDLAKLHS | SSHPTSIVKA | GSCGEAYAPQ | GWIAFFMEYV |
600:
KRFVVSCVPS | WFWGPVVTLQ | DCLAAFFARD | ELKGDNMYSC | EKCKKLRNGV |
650:
KFCKVQNFPE | ILCIHLKRFR | HELMFSTKIS | THVSFPLEGL | DLQPFLAKDS |
700:
PAQIVTYDLL | SVICHHGTAS | SGHYIAYCRN | NLNNLWYEFD | DQSVTEVSES |
750:
TVQNAEAYVL | FYRKSSEEAQ | KERRRISNLL | NIMEPSLLQF | YISRQWLNKF |
800:
KTFAEPGPIS | NNDFLCIHGG | VPPRKAGYIE | DLVLMLPQNI | WDNLYSRYGG |
850:
GPAVNHLYIC | HTCQIEAEKI | EKRRKTELEI | FIRLNRAFQK | EDSPATFYCI |
900:
SMQWFREWES | FVKGKDGDPP | GPIDNTKIAV | TKCGNVMLRQ | GADSGQISEE |
942:
TWNFLQSIYG | GGPEVILRPP | VVHVDPDILQ | AEEKIEVETR | SL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 33
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 33
Protein for Human Ubiquitin carboxyl-terminal hydrolase 33
Protein for Human Ubiquitin carboxyl-terminal hydrolase 33
Protein for Human Ubiquitin carboxyl-terminal hydrolase 33
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);UBIQUITINATION;INTERACTION WITH VHL;TISSUE SPECIFICITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Eye .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DIO2
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SELENBP1;SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ADRB2;MUTAGENESIS OF CYS-194 AND HIS-673
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ARRB1 AND ARRB2;MUTAGENESIS OF CYS-194 AND HIS-673
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORM 3);SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CCP110;DEVELOPMENTAL STAGE;MUTAGENESIS OF CYS-194 AND HIS-673
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 36-130;ZINC-BINDING;DOMAIN UBP-TYPE ZINC FINGER