Gene name:
USP37 (KIAA1594) ;
Protein name:
Ubiquitin carboxyl-terminal hydrolase 37 ;
Alternative:
Ubiquitin thiolesterase 37 ;Deubiquitinating enzyme 37 ;Ubiquitin-specific-processing protease 37 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with FZR1/CDH1.
Function:
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).
Subcellular Location:
N/A
Protein Attributes:
50:
MSPLKIHGPI | RIRSMQTGIT | KWKEGSFEIV | EKENKVSLVV | HYNTGGIPRI |
100:
FQLSHNIKNV | VLRPSGAKQS | RLMLTLQDNS | FLSIDKVPSK | DAEEMRLFLD |
150:
AVHQNRLPAA | MKPSQGSGSF | GAILGSRTSQ | KETSRQLSYS | DNQASAKRGS |
200:
LETKDDIPFR | KVLGNPGRGS | IKTVAGSGIA | RTIPSLTSTS | TPLRSGLLEN |
250:
RTEKRKRMIS | TGSELNEDYP | KENDSSSNNK | AMTDPSRKYL | TSSREKQLSL |
300:
KQSEENRTSG | LLPLQSSSFY | GSRAGSKEHS | SGGTNLDRTN | VSSQTPSAKR |
350:
SLGFLPQPVP | LSVKKLRCNQ | DYTGWNKPRV | PLSSHQQQQL | QGFSNLGNTC |
400:
YMNAILQSLF | SLQSFANDLL | KQGIPWKKIP | LNALIRRFAH | LLVKKDICNS |
450:
ETKKDLLKKV | KNAISATAER | FSGYMQNDAH | EFLSQCLDQL | KEDMEKLNKT |
500:
WKTEPVSGEE | NSPDISATRA | YTCPVITNLE | FEVQHSIICK | ACGEIIPKRE |
550:
QFNDLSIDLP | RRKKPLPPRS | IQDSLDLFFR | AEELEYSCEK | CGGKCALVRH |
600:
KFNRLPRVLI | LHLKRYSFNV | ALSLNNKIGQ | QVIIPRYLTL | SSHCTENTKP |
650:
PFTLGWSAHM | AISRPLKASQ | MVNSCITSPS | TPSKKFTFKS | KSSLALCLDS |
700:
DSEDELKRSV | ALSQRLCEML | GNEQQQEDLE | KDSKLCPIEP | DKSELENSGF |
750:
DRMSEEELLA | AVLEISKRDA | SPSLSHEDDD | KPTSSPDTGF | AEDDIQEMPE |
800:
NPDTMETEKP | KTITELDPAS | FTEITKDCDE | NKENKTPEGS | QGEVDWLQQY |
850:
DMEREREEQE | LQQALAQSLQ | EQEAWEQKED | DDLKRATELS | LQEFNNSFVD |
900:
ALGSDEDSGN | EDVFDMEYTE | AEAEELKRNA | ETGNLPHSYR | LISVVSHIGS |
950:
TSSSGHYISD | VYDIKKQAWF | TYNDLEVSKI | QEAAVQSDRD | RSGYIFFYMH |
979:
KEIFDELLET | EKNSQSLSTE | VGKTTRQAL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Dog
Pig
Chicken
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-979
tissue :
Spinal cord .
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-979
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT SER-979
tissue :
Testis .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-979 (ISOFORM 1);VARIANT SER-979
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;ENZYME ACTIVITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-650 AND SER-652;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;UBIQUITINATION;PHOSPHORYLATION AT SER-628 BY CDK2;DOMAIN KEN BOX 3;DEVELOPMENTAL STAGE;INDUCTION;INTERACTION WITH FZR1;MUTAGENESIS OF 32-LYS--ASN-34; 71-ARG-LEU-74; 96-ARG-LEU-99; 160-ARG-LEU-163; 221-LYS--ASN-223; CYS-350; 782-LYS--ASN-784 AND SER-628