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Index > Protein center > USP37(Gene name) > Human
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  • USP37 (Gene name),
  • Ubiquitin carboxyl-terminal hydrolase 37 (Protein name ),  UBP37_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    USP37(KIAA1594);
    Protein name:
    Ubiquitin carboxyl-terminal hydrolase 37;
    Alternative:
    Ubiquitin thiolesterase 37;Deubiquitinating enzyme 37;Ubiquitin-specific-processing protease 37;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with FZR1/CDH1.
    Function:
    Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    979
    Sequence:
    50:
    MSPLKIHGPI | RIRSMQTGIT | KWKEGSFEIV | EKENKVSLVV | HYNTGGIPRI | 
    100:
    FQLSHNIKNV | VLRPSGAKQS | RLMLTLQDNS | FLSIDKVPSK | DAEEMRLFLD | 
    150:
    AVHQNRLPAA | MKPSQGSGSF | GAILGSRTSQ | KETSRQLSYS | DNQASAKRGS | 
    200:
    LETKDDIPFR | KVLGNPGRGS | IKTVAGSGIA | RTIPSLTSTS | TPLRSGLLEN | 
    250:
    RTEKRKRMIS | TGSELNEDYP | KENDSSSNNK | AMTDPSRKYL | TSSREKQLSL | 
    300:
    KQSEENRTSG | LLPLQSSSFY | GSRAGSKEHS | SGGTNLDRTN | VSSQTPSAKR | 
    350:
    SLGFLPQPVP | LSVKKLRCNQ | DYTGWNKPRV | PLSSHQQQQL | QGFSNLGNTC | 
    400:
    YMNAILQSLF | SLQSFANDLL | KQGIPWKKIP | LNALIRRFAH | LLVKKDICNS | 
    450:
    ETKKDLLKKV | KNAISATAER | FSGYMQNDAH | EFLSQCLDQL | KEDMEKLNKT | 
    500:
    WKTEPVSGEE | NSPDISATRA | YTCPVITNLE | FEVQHSIICK | ACGEIIPKRE | 
    550:
    QFNDLSIDLP | RRKKPLPPRS | IQDSLDLFFR | AEELEYSCEK | CGGKCALVRH | 
    600:
    KFNRLPRVLI | LHLKRYSFNV | ALSLNNKIGQ | QVIIPRYLTL | SSHCTENTKP | 
    650:
    PFTLGWSAHM | AISRPLKASQ | MVNSCITSPS | TPSKKFTFKS | KSSLALCLDS | 
    700:
    DSEDELKRSV | ALSQRLCEML | GNEQQQEDLE | KDSKLCPIEP | DKSELENSGF | 
    750:
    DRMSEEELLA | AVLEISKRDA | SPSLSHEDDD | KPTSSPDTGF | AEDDIQEMPE | 
    800:
    NPDTMETEKP | KTITELDPAS | FTEITKDCDE | NKENKTPEGS | QGEVDWLQQY | 
    850:
    DMEREREEQE | LQQALAQSLQ | EQEAWEQKED | DDLKRATELS | LQEFNNSFVD | 
    900:
    ALGSDEDSGN | EDVFDMEYTE | AEAEELKRNA | ETGNLPHSYR | LISVVSHIGS | 
    950:
    TSSSGHYISD | VYDIKKQAWF | TYNDLEVSKI | QEAAVQSDRD | RSGYIFFYMH | 
    979:
    KEIFDELLET | EKNSQSLSTE | VGKTTRQAL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 37
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 37
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 37
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 37

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-979
      tissue: Spinal cord.
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-979
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT SER-979
      tissue: Testis.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Nakayama M. , Hirosawa M. , Ohara O.
      DNA Res.7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-979 (ISOFORM 1);VARIANT SER-979
      tissue: Brain.
    6. 6.
      "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
      Quesada V. , Diaz-Perales A. , Gutierrez-Fernandez A. , Garabaya C. , Cal S. , Lopez-Otin C.
      Biochem. Biophys. Res. Commun.314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;ENZYME ACTIVITY
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-650 AND SER-652;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry."
      Huang X. , Summers M.K. , Pham V. , Lill J.R. , Liu J. , Lee G. , Kirkpatrick D.S. , Jackson P.K. , Fang G. , Dixit V.M.
      Mol. Cell42:511-523(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITINATION;PHOSPHORYLATION AT SER-628 BY CDK2;DOMAIN KEN BOX 3;DEVELOPMENTAL STAGE;INDUCTION;INTERACTION WITH FZR1;MUTAGENESIS OF 32-LYS--ASN-34; 71-ARG-LEU-74; 96-ARG-LEU-99; 160-ARG-LEU-163; 221-LYS--ASN-223; CYS-350; 782-LYS--ASN-784 AND SER-628
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