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Index > Protein center > Usp4(Gene name) > Mouse
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  • Usp4 (Gene name),
  • Ubiquitin carboxyl-terminal hydrolase 4 (Protein name ),  UBP4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Usp4(Unp);
    Protein name:
    Ubiquitin carboxyl-terminal hydrolase 4;
    Alternative:
    Ubiquitin thiolesterase 4;Deubiquitinating enzyme 4;Ubiquitous nuclear protein;Ubiquitin-specific-processing protease 4;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with RB1 (both dephosphorylated and hypophosphorylated forms). Interacts with ADORA2A (via cytoplasmic C-terminus); the interaction is direct (By similarity). Interacts with RB1, RBL1 and RBL2.
    Function:
    Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER.
    Subcellular Location:
    Cytoplasm Nucleus Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor.
    Protein Attributes:
    Sequence length:
    962
    Sequence:
    50:
    MAEGRGSRER | PDVETQKTEL | GALMGTTLQR | GAQWYLIDSR | WFKQWKKYVG | 
    100:
    FDSWDMYNVG | EHNLFPGPID | NSGLFSDPES | QTLKEHLIDE | LDYVLVPAEA | 
    150:
    WNKLLNWYGC | VEGQQPIVRK | VVEHGLFVKH | CKVEVYLLEL | KLCENSDPTN | 
    200:
    VLSCHFSKAD | TIATIEKEMR | KLFNIPAERE | TRLWNKYMSN | TYEQLSKLDN | 
    250:
    TIQDAGLYQG | QVLVIEPQNE | DGTWPRQSLQ | SKSSTAPSRN | FTTSSKPSAS | 
    300:
    PYCSVSASLI | ANGDSTNSSG | MHSSGVSRGG | SGFSASYNCQ | EPPSPHIQPG | 
    350:
    LCGLGNLGNT | CFMNSALQCL | SNTAPLTEYF | LKDEYEAEIN | RDNPLGMKGE | 
    400:
    IAEAYAELIK | QMWSGRDTHV | APRMFKTQVG | RFAPQFSGYQ | QQDSQELLAF | 
    450:
    ILDGLHEDLN | RVKKKPYLEP | KDANGRPDAV | VAKEAWENHR | LRNDSVIVDT | 
    500:
    FHGLFKSTLV | CPECAKVSVT | FDPFCYLTLP | LPLKKDRIME | VFLVPADPQC | 
    550:
    RPIQYRVTVP | LMGAISDLCE | ALSKLSGIAA | ENMVVTDVYN | HRFHKIFQMD | 
    600:
    EGLSHITPRD | DIFVYEVCNT | SMDGSECITL | PVYFREKKSR | PSSASSGAVL | 
    650:
    YGQPLLVSVP | KHKLTLESLY | QAVCDRISRY | IKQPLPDEFL | SSPLEPGACN | 
    700:
    GSRSSYEGDE | EEEMDHQEEG | KEQLSEVEGS | GEDDQGDDHS | ESAQKVKGQP | 
    750:
    RHKRLFTFSL | VNSCGTADIN | SLATDGKLLK | LNSRSTLAID | WDSETRSLYF | 
    800:
    DEQESEACEK | HLSMSQPQKK | KKAAVALREC | IELFTTMETL | GEHDPWYCPT | 
    850:
    CKKHQQATKK | FDLWSLPKIL | VVHLKRFSYN | RYWRDKLDTV | VEFPVRALNM | 
    900:
    SEFVCDRSAR | PYVYDLIAVS | NHYGAMGVGH | YTAYAKNRLN | GKWYYFDDSS | 
    950:
    VSLASEDQIV | TKAAYVLFYQ | RRDDECSSTS | SLGSFPGSDG | GVKLSSSHQG | 
    962:
    MGDEEAYNMD | TN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 4
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 4

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    Precision
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    Linearity
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    References
    1. 1.
      "Unp, a mouse gene related to the tre oncogene."
      Gupta K. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Gray D.A.
      Oncogene8:2307-2310(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease."
      di Fruscio M. , Gilchrist C.A. , Baker R.T. , Gray D.A.
      Biochim. Biophys. Acta1398:9-17(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129.
      tissue: Testis.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Bone marrow.
      tissue: Spleen.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130."
      Blanchette P. , Gilchrist C.A. , Baker R.T. , Gray D.A.
      Oncogene20:5533-5537(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RB1; RBL1 AND RBL2;MUTAGENESIS OF CYS-461
    6. 6.
      "Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme."
      Soboleva T.A. , Jans D.A. , Johnson-Saliba M. , Baker R.T.
      J. Biol. Chem.280:745-752(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 770-GLN--LYS-771;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    7. 7.
      "Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)."
      Structural genomics consortium (SGC)
      Submitted (2009-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 1-229
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