Ubr1 ELISA Kit for Mouse(Mus musculus) | EIAab.comUbr1 ELISA Kit for Mouse(Mus musculus)

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Ubr1 (Gene name),

E3 ubiquitin-protein ligase UBR1 (Protein name ), UBR1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ubr1;

Protein name:

E3 ubiquitin-protein ligase UBR1;

Alternative:

Ubiquitin-protein ligase E3-alpha-1;N-recognin-1;Ubiquitin-protein ligase E3-alpha-I;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with RECQL4.

Function:

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Subcellular Location:

Cytoplasm cytosol

Protein Attributes:

Sequence length:

1757

Sequence:

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1750:

1757:

GFNWQLL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF02617

KEGG:

mmu:22222

UniGene:

Mm.389330

String:

O70481

SMR:

O70481

Uniprot:

O70481

FOR

ELISA Kit for Mouse E3 ubiquitin-protein ligase UBR1

Cat.:

E2362h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse E3 ubiquitin-protein ligase UBR1

Cat.:

E2362m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase UBR1

Cat.:

U2362m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase UBR1

Cat.:

U2362h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase UBR1

Cat.:

P2362Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase UBR1

Cat.:

P2362Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase UBR1

Protein for Mouse E3 ubiquitin-protein ligase UBR1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"The mouse and human genes encoding the recognition component of the N-end rule pathway."
Kwon Y.T. , Reiss Y. , Fried V.A. , Hershko A. , Yoon J.K. , Gonda D.K. , Sangan P. , Copeland N.G. , Jenkins N.A. , Varshavsky A.
Proc. Natl. Acad. Sci. U.S.A.95:7898-7903(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain: 129/SvJ.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-849 AND 1529-1757
strain: NOD.
tissue: Olfactory bulb.
tissue: Spleen.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-852
strain: C57BL/6.
tissue: Brain.
5.

"Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway."
Kwon Y.T. , Xia Z. , Davydov I.V. , Lecker S.H. , Varshavsky A.
Mol. Cell. Biol.21:8007-8021(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION
6.

"Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway."
Kwon Y.T. , Xia Z. , An J.Y. , Tasaki T. , Davydov I.V. , Seo J.W. , Sheng J. , Xie Y. , Varshavsky A.
Mol. Cell. Biol.23:8255-8271(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION
7.

"Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia."
Kwak K.S. , Zhou X. , Solomon V. , Baracos V.E. , Davis J. , Bannon A.W. , Boyle W.J. , Lacey D.L. , Han H.Q.
Cancer Res.64:8193-8198(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
8.

"Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)."
Zenker M. , Mayerle J. , Lerch M.M. , Tagariello A. , Zerres K. , Durie P.R. , Beier M. , Hulskamp G. , Guzman C. , Rehder H. , Beemer F.A. , Hamel B.C.J. , Vanlieferinghen P. , Gershoni-Baruch R. , Vieira M.W. , Dumic M. , Auslender R. , Gil-da-Silva-Lopes V.L. , more...
Nat. Genet.37:1345-1350(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
9.

"Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway."
An J.Y. , Seo J.W. , Tasaki T. , Lee M.J. , Varshavsky A. , Kwon Y.T.
Proc. Natl. Acad. Sci. U.S.A.103:6212-6217(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE

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