UBXN1 ELISA Kit for Human(Homo sapiens) | EIAab.comUBXN1 ELISA Kit for Human(Homo sapiens)

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UBXN1 (Gene name),

UBX domain-containing protein 1 (Protein name ), UBXN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UBXN1(SAKS1);

Protein name:

UBX domain-containing protein 1;

Alternative:

UBA/UBX 33.3 kDa protein;SAPK substrate protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with HOMER2 (By similarity). Interacts directly with VCP. Interacts with BRCA1 and BARD1; interaction takes place when BRCA1 is not autoubiquitinated but is strongly enhanced in the presence of autoubiquitinated BRCA1.

Function:

Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

297

Sequence:

50:

100:

150:

200:

250:

297:

LGGGQDPVQL | LSGFPRRAFS | EADMERPLQE | LGLVPSAVLI | VAKKCPS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00627

UniGene:

Hs.351296

KEGG:

hsa:51035

String:

Q04323

SMR:

Q04323

STRING:

9606.ENSP00000294119

Uniprot:

Q04323

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ELISA Kit for Human UBX domain-containing protein 1

Cat.:

E6426h

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96T

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ELISA Kit for Human UBX domain-containing protein 1

Cat.:

E6426r

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96T

ELISA Kit for Human UBX domain-containing protein 1

Cat.:

E6426b

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96T

ELISA Kit for Human UBX domain-containing protein 1

Cat.:

E6426m

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96T

CLIA Kit for Human UBX domain-containing protein 1

Cat.:

U6426b

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Packing:

96T

CLIA Kit for Human UBX domain-containing protein 1

Cat.:

U6426m

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Packing:

96T

CLIA Kit for Human UBX domain-containing protein 1

Cat.:

U6426h

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MSDS:

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Packing:

96T

CLIA Kit for Human UBX domain-containing protein 1

Cat.:

U6426r

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96T

Polyclonal Antibody for Human UBX domain-containing protein 1

Cat.:

P6426Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human UBX domain-containing protein 1

Cat.:

P6426Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human UBX domain-containing protein 1

Cat.:

P6426Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human UBX domain-containing protein 1

Protein for Human UBX domain-containing protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

Pollard K.M.
Submitted (1991-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Colon.
tissue: Placenta.
tissue: Skin.
3.

"A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs."
McNeill H. , Knebel A. , Arthur J.S. , Cuenda A. , Cohen P.
Biochem. J.384:391-400(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 220-231 AND 276-285;PHOSPHORYLATION AT SER-200;INTERACTION WITH VCP
4.

Lubec G. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 220-231;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Fetal brain cortex.
5.

"UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover."
Alexandru G. , Graumann J. , Smith G.T. , Kolawa N.J. , Fang R. , Deshaies R.J.
Cell134:804-816(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITIN-BINDING;INTERACTION WITH VCP
6.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
7.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
8.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
9.

"The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function."
Wu-Baer F. , Ludwig T. , Baer R.
Mol. Cell. Biol.30:2787-2798(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITIN-BINDING;DOMAIN UBA;INTERACTION WITH BRCA1 AND BARD1;MUTAGENESIS OF MET-13 AND ARG-219
10.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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