Gene name:
UPK1A (TSPAN21) ;
Protein name:
Uroplakin-1a (UP1a) ;
Alternative:
Uroplakin Ia (UPIa;UPKa) ;Tetraspanin-21 (Tspan-21) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Interacts with uroplakin-2 (UPK2).
Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MASAAAAEAE | KGSPVVVGLL | VVGNIIILLS | GLSLFAETIW | VTADQYRVYP |
100:
LMGVSGKDDV | FAGAWIAIFC | GFSFFMVASF | GVGAALCRRR | SMVLTYLVLM |
150:
LIVYIFECAS | CITSYTHRDY | MVSNPSLITK | QMLTFYSADT | DQGQELTRLW |
200:
DRVMIEQECC | GTSGPMDWVN | FTSAFRAATP | EVVFPWPPLC | CRRTGNFIPL |
250:
NEEGCRLGHM | DYLFTKGCFE | HIGHAIDSYT | WGISWFGFAI | LMWTLPVMLI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
Polyclonal Antibody for Human UP1a
Polyclonal Antibody for Human UP1a
Polyclonal Antibody for Human UP1a
Monoclonal Antibody for Human UP1a
Monoclonal Antibody for Human UP1a
Monoclonal Antibody for Human UP1a
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature428:529-535(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT THR-257
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 3-258 (ISOFORM 1);TISSUE SPECIFICITY
tissue :
Ureter .
4.
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Cited for : TISSUE SPECIFICITY