Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1. Interacts with GNB2L1/RACK1.
Function:
Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform 2 and isoform 3 may have an inhibitory role in angiogenesis.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF N-TERMINUS;SUBCELLULAR LOCATION (ISOFORM 2);INTERACTION WITH VEGFA;FUNCTION
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH VEGFA;GLYCOSYLATION
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);FUNCTION IN LIGAND BINDING;SUBCELLULAR LOCATION
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;ROLE IN PREECLAMPSIA;INDUCTION
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5; 6; 7 AND 8);ALTERNATIVE SPLICING;FUNCTION IN PHOSPHORYLATION OF SRC AND CANCER CELL INVASIVENESS;TISSUE SPECIFICITY
7.
"A new VEGFR1 receptor transcript coding for the extracellular domains of the protein followed by a C-terminal polyserine tail." Mezquita J.
,
Mezquita B.
,
Pau M.
,
Mezquita C.
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1018-1058;ALTERNATIVE SPLICING (ISOFORM 1)
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Cited for: PARTIAL PROTEIN SEQUENCE;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-914; TYR-1213; TYR-1242; TYR-1327 AND TYR-1333;MUTAGENESIS OF TYR-914; TYR-1213; TYR-1242; TYR-1327 AND TYR-1333;INTERACTION WITH PLCG; GRB2; CRK; NCK1 AND PTPN11
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Cited for: INTERACTION WITH VEGFA;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;FUNCTION IN PHOSPHORYLATION OF PLCG;ABSENCE OF MITOGENIC FUNCTION IN CULTURED FIBROBLASTS
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Cited for: FUNCTION IN CELL MIGRATION;FUNCTION IN VEGFA AND PGF SIGNALING;INDUCTION
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Cited for: FUNCTION IN PHOSPHORYLATION OF PLCG AND ACTIVATION OF MAP KINASES;INTERACTION WITH PLCG;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-861 AND TYR-1169;PHOSPHORYLATION AT TYR-1169 AND TYR-1213
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Cited for: INTERACTION WITH PIK3R1; PTPN11 AND NCK1;PHOSPHORYLATION AT TYR-1213
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Cited for: FUNCTION AS NEGATIVE REGULATOR OF KDR-MEDIATED CELL PROLIFERATION
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Cited for: INTERACTION WITH PIK3R1 AND VEGFA;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-1213;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;GLYCOSYLATION
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Cited for: FUNCTION IN PGF-MEDIATED CHORIOCARCINOMA CELL PROLIFERATION
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Cited for: INTERACTION WITH KDR;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;FUNCTION IN VEGFA SIGNALING; PHOSPHORYLATION OF PLCG AND ACTIVATION OF PHOSPHATIDYLINOSITOL KINASE AND PHOSPHOLIPASE C
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Cited for: FUNCTION IN SIGNALING VIA ACTIVATION OF THE PHOSPHATIDYLINOSITOL KINASE PATHWAY AND POSITIVE REGULATION OF ANGIOGENESIS IN RESPONSE TO PGF AND VEGFA
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Cited for: INTERACTION WITH PGF AND KDR;FUNCTION IN PHOSPHORYLATION OF KDR; VEGFA AND PGF SIGNALING;CATALYTIC ACTIVITY;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT TYR-1213; TYR-1327 AND TYR-1309
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Cited for: INTERACTION WITH CBL AND CD2AP;UBIQUITINATION;AUTOPHOSPHORYLATION IN RESPONSE TO VEGFA;MUTAGENESIS OF TYR-1333;SUBCELLULAR LOCATION
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Cited for: FUNCTION IN VEGFA AND VEGFB SIGNALING; CANCER CELL MIGRATION; INVASIVENESS AND ACTIVATION OF MAPK1/ERK2 AND MAPK3/ERK1
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Cited for: FUNCTION IN CELL MIGRATION AND PHOSPHORYLATION OF PTK2/FAK1; YES1 AND SRC
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Cited for: FUNCTION IN PGF AND VEGFA SIGNALING; PHOSPHORYLATION OF AKT1; MAPK3/ERK1 AND MAP KINASES; CHEMOTAXIS AND ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE;AUTOPHOSPHORYLATION IN RESPONSE TO PGF AND VEGFA
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Cited for: FUNCTION IN ENDOTHELIAL CELL SURVIVAL AND ANGIOGENESIS
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Cited for: FUNCTION IN CANCER CELL MIGRATION AND ACTIVATION OF MAPK1/ERK2 AND/OR MAPK3/ERK1
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Cited for: INTERACTION WITH PSEN1 AND PTPRB;DEPHOSPHORYLATION BY PTPRB;MUTAGENESIS OF VAL-767;PROTEOLYTIC CLEAVAGE BY PSEN1 AT VAL-767
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Cited for: FUNCTION AS DECOY RECEPTORS; REGULATION OF VEGFA SIGNALING AND REGULATION OF KDR ACTIVITY (ISOFORMS 2/3/4);ROLE IN PREECLAMPSIA
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Cited for: REVIEW ON FUNCTION AS NEGATIVE REGULATOR OF ANGIOGENESIS DURING EMBRYONIC DEVELOPMENT; POSITIVE REGULATION OF MACROPHAGE FUNCTION IN ADULTHOOD; ROLE IN CARCINOGENESIS AND INFLAMMATION
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Cited for: REVIEW ON LIGAND SPECIFICITY; FUNCTION; STRUCTURE; PHOSPHORYLATION AND SIGNALING
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Cited for: REVIEW ON LIGAND SPECIFICITY; FUNCTION; STRUCTURE; PHOSPHORYLATION AND SIGNALING
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Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 132-226 IN COMPLEX WITH VEGFA;DOMAIN
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Cited for: STRUCTURE BY NMR OF 129-229;X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 129-229 IN COMPLEX WITH VEGFA;SUBUNIT;INTERACTION WITH VEGFA
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Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 130-229 IN COMPLEX WITH PGF
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Cited for: X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) OF 129-226 IN COMPLEX WITH VEGFB;INTERACTION WITH VEGFB;SUBUNIT;DOMAIN
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Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-60; LYS-144; GLN-281; ILE-422; GLN-781; VAL-938; ALA-982 AND VAL-1061