VCL ELISA Kit for Human(Homo sapiens) | EIAab.comVCL ELISA Kit for Human(Homo sapiens)

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Index > Protein center > VCL(Gene name) > Human

VCL (Gene name),

Vinculin (Protein name ), VINC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

VCL;

Protein name:

Vinculin;

Alternative:

Metavinculin(MV);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Exhibits self-association properties. Interacts with NRAP and SORBS1 (By similarity). Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.

Function:

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

Subcellular Location:

Cytoplasm cytoskeleton Cell junction adherens junction Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.

Protein Attributes:

Sequence length:

1134

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

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750:

800:

850:

900:

950:

1000:

1050:

1100:

1134:

SVKETVREAE | AASIKIRTDA | GFTLRWVRKT | PWYQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P18206

STRING:

9606.ENSP00000211998

UniGene:

Hs.643896

SMR:

P18206

Pfam:

PF01044

KEGG:

hsa:7414

MIM:

193065

Uniprot:

P18206

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ELISA Kit for Human Vinculin

Cat.:

E1839r

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96T

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ELISA Kit for Human Vinculin

Cat.:

E1839c

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96T

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ELISA Kit for Human Vinculin

Cat.:

E1839p

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96T

ELISA Kit for Human Vinculin

Cat.:

E1839h

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96T

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ELISA Kit for Human Vinculin

Cat.:

E1839m

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96T

CLIA Kit for Human Vinculin

Cat.:

U1839h

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96T

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CLIA Kit for Human Vinculin

Cat.:

U1839p

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96T

CLIA Kit for Human Vinculin

Cat.:

U1839c

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96T

CLIA Kit for Human Vinculin

Cat.:

U1839r

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Packing:

96T

CLIA Kit for Human Vinculin

Cat.:

U1839m

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Packing:

96T

Polyclonal Antibody for Human Vinculin

Cat.:

P1839Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Vinculin

Cat.:

P1839Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Vinculin

Cat.:

P1839Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human Vinculin

Protein for Human Vinculin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Complete sequence of human vinculin and assignment of the gene to chromosome 10."
Weller P.A. , Ogryzko E.P. , Corben E.B. , Zhidkova N.I. , Patel B. , Price G.J. , Spurr N.K. , Koteliansky V.E. , Critchley D.R.
Proc. Natl. Acad. Sci. U.S.A.87:5667-5671(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Endothelial cell.
2.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Retina.
3.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-234
tissue: Prostate.
5.

"Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter."
Moiseyeva E.P. , Weller P.A. , Zhidkova N.I. , Corben E.B. , Patel B. , Jasinska I. , Koteliansky V.E. , Critchley D.R.
J. Biol. Chem.268:4318-4325(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56;ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
6.

Lubec G. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 114-132; 247-261; 327-339; 353-366; 465-476 AND 548-561;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Fetal brain cortex.
7.

"An additional exon in the human vinculin gene specifically encodes meta-vinculin-specific difference peptide. Cross-species comparison reveals variable and conserved motifs in the meta-vinculin insert."
Koteliansky V.E. , Ogryzko E.P. , Zhidkova N.I. , Weller P.A. , Critchley D.R. , Vancompernolle K. , Vandekerckhove J. , Strasser P. , Way M. , Gimona M. , Small J.V.
Eur. J. Biochem.204:767-772(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 854-1051;ALTERNATIVE SPLICING (ISOFORM 2)
tissue: Uterus.
8.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-7 (ISOFORMS 1/2)
tissue: Platelet.
9.

"The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading."
Zhang Z. , Izaguirre G. , Lin S.-Y. , Lee H.Y. , Schaefer E. , Haimovich B.
Mol. Biol. Cell15:4234-4247(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-1133;IDENTIFICATION BY MASS SPECTROMETRY
10.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-721;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Human alpha-synemin interacts directly with vinculin and metavinculin."
Sun N. , Critchley D.R. , Paulin D. , Li Z. , Robson R.M.
Biochem. J.409:657-667(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYNM
12.

"Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers."
Huggins C.J. , Andrulis I.L.
Cancer Lett.267:55-66(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
13.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290; SER-721 AND TYR-822;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-173 AND LYS-496;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Vinculin is a dually regulated actin filament barbed end-capping and side-binding protein."
Le Clainche C. , Dwivedi S.P. , Didry D. , Carlier M.F.
J. Biol. Chem.285:23420-23432(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN
16.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-290 AND SER-721;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290; SER-346; SER-434 AND SER-721;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"The C-terminal tail domain of metavinculin, vinculin's splice variant, severs actin filaments."
Janssen M.E. , Liu H. , Volkmann N. , Hanein D.
J. Cell Biol.197:585-593(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 2)
20.

"Structural basis for amplifying vinculin activation by talin."
Izard T. , Vonrhein C.
J. Biol. Chem.279:27667-27678(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 1-258 IN COMPLEX WITH TLN1
21.

"Vinculin activation by talin through helical bundle conversion."
Izard T. , Evans G. , Borgon R.A. , Rush C.L. , Bricogne G. , Bois P.R.J.
Nature427:171-175(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-258 IN COMPLEX WITH TLN1
22.

"Metavinculin mutations alter actin interaction in dilated cardiomyopathy."
Olson T.M. , Illenberger S. , Kishimoto N.Y. , Huttelmaier S. , Keating M.T. , Jockusch B.M.
Circulation105:431-437(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMD1W LEU-954 DEL AND TRP-975;CHARACTERIZATION OF VARIANT CMD1W TRP-975
23.

"Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy."
Vasile V.C. , Will M.L. , Ommen S.R. , Edwards W.D. , Olson T.M. , Ackerman M.J.
Mol. Genet. Metab.87:169-174(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD1W TRP-975;VARIANTS VAL-934 AND ALA-943
24.

"A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy."
Vasile V.C. , Ommen S.R. , Edwards W.D. , Ackerman M.J.
Biochem. Biophys. Res. Commun.345:998-1003(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMH15 MET-277

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