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Index > Protein center > Vrk1(Gene name) > Mouse
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  • Vrk1 (Gene name),
  • Serine/threonine-protein kinase VRK1 (Protein name ),  VRK1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Vrk1;
    Protein name:
    Serine/threonine-protein kinase VRK1;
    Alternative:
    Vaccinia-related kinase 1;Serine/threonine-protein kinase 51PK;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Serine/threonine kinase that phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm.
    Subcellular Location:
    Cytoplasm Nucleus Cytoplasm cytoskeleton spindle Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
    Protein Attributes:
    Sequence length:
    440
    Sequence:
    50:
    MPRVKAAQAG | RPGPAKRRLA | EQFAAGEVLT | DMSRKEWKLG | LPIGQGGFGC | 
    100:
    IYLADTNSSK | PVGSDAPCVV | KVEPSDNGPL | FTELKFYQRA | AKPEQIQKWI | 
    150:
    RTHKLKYLGV | PKYWGSGLHD | KNGKSYRFMI | MDRFGSDLQK | IYEANAKRFS | 
    200:
    RKTVLQLSLR | ILDILEYIHE | HEYVHGDIKA | SNLLLSHKNP | DQVYLVDYGL | 
    250:
    AYRYCPDGVH | KEYKEDPKRC | HDGTLEFTSI | DAHKGVAPSR | RGDLEILGYC | 
    300:
    MIQWLSGCLP | WEDNLKDPNY | VRDSKIRYRD | NVAALMEKCF | PEKNKPGEIA | 
    350:
    KYMESVKLLE | YTEKPLYQNL | RDILLQGLKA | IGSKDDGKLD | FSAVENGSVK | 
    400:
    TRPASKKRKK | EAEESAVCAV | EDMECSDTQV | QEAAQTRSVE | SQGAIHGSMS | 
    440:
    QPAAGCSSSD | SSRRQQHLGL | EQDMLRLDRR | GSRTRKKAQK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Serine/threonine-protein kinase VRK1
    ELISA Kit for Mouse Serine/threonine-protein kinase VRK1
    ELISA Kit for Mouse Serine/threonine-protein kinase VRK1
    CLIA Kit for Mouse Serine/threonine-protein kinase VRK1
    CLIA Kit for Mouse Serine/threonine-protein kinase VRK1
    CLIA Kit for Mouse Serine/threonine-protein kinase VRK1
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase VRK1
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase VRK1
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase VRK1
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase VRK1
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase VRK1
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase VRK1
    Protein for Mouse Serine/threonine-protein kinase VRK1
    Protein for Mouse Serine/threonine-protein kinase VRK1
    Protein for Mouse Serine/threonine-protein kinase VRK1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and characterization of a novel nuclear protein kinase in mice."
      Zelko I.N. , Kobayashi R. , Honkakoski P. , Negishi M.
      Arch. Biochem. Biophys.352:31-36(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);PROTEIN SEQUENCE OF 19-33; 267-275 AND 278-288;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;AUTOPHOSPHORYLATION
      tissue: Testis.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5)
      strain: NOD.
      tissue: Olfactory bulb.
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Mammary tumor.
      tissue: Olfactory epithelium.
    4. 4.
      "Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development."
      Vega F.M. , Gonzalo P. , Gaspar M.L. , Lazo P.A.
      FEBS Lett.544:176-180(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    5. 5.
      "Characterization of three paralogous members of the Mammalian vaccinia related kinase family."
      Nichols R.J. , Traktman P.
      J. Biol. Chem.279:7934-7946(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION
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