VTN ELISA Kit for Human(Homo sapiens) | EIAab.comVTN ELISA Kit for Human(Homo sapiens)

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Index > Protein center > VTN(Gene name) > Human

VTN (Gene name),

Vitronectin (Protein name ), VTNC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (3)

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Gene name:

VTN;

Protein name:

Vitronectin(VN);

Alternative:

Serum-spreading factor;S-protein;V75;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.

Function:

Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Subcellular Location:

Secreted extracellular space

Protein Attributes:

Sequence length:

478

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

478:

TRRVDTVDPP | YPRSIAQYWL | GCPAPGHL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

193190

UniGene:

Hs.2257

STRING:

9606.ENSP00000226218

Pfam:

PF00045

SMR:

P04004

String:

P04004

KEGG:

hsa:7448

Uniprot:

P04004

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ELISA Kit for Human VN

MSDS:

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ELISA Kit for Human VN

Cat.:

E1041p

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Manual:

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Packing:

96T

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ELISA Kit for Human VN

Cat.:

E1041h

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96T

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ELISA Kit for Human VN

Cat.:

E1041m

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96T

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CLIA Kit for Human VN

Cat.:

U1041m

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Packing:

96T

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CLIA Kit for Human VN

Cat.:

U1041p

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96T

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CLIA Kit for Human VN

MSDS:

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CLIA Kit for Human VN

Cat.:

U1041h

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Packing:

96T

Polyclonal Antibody for Human VN

Cat.:

P1041Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human VN

Cat.:

P1041Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human VN

Protein for Human VN

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Clinical significance of serum fibronectin and vitronectin levels in melanoma patients"

F Tas, S Karabulut, E Bilgin, et al.

From:Melanoma Research

[2].

"The predictive and prognostic value evaluation of serum extracellular matrix proteins levels in patients with pancreas adenocarcinoma"

S Karabulut, M Karabulut, H Alış, et al.

From:Medical Journal of Bakirkoy

[3].

"Pankreas Adenokanserli Hastalarda Serum Ekstraselluler Matriks Proteinlerinin Prognostik ve Prediktif..."

Karabulut S, Karabulut M,

From:Medical Journal of Bakirkoy

References

1.

"Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin."
Suzuki S. , Oldberg A. , Hayman E.G. , Pierschbacher M.D. , Ruoslahti E.
EMBO J.4:2519-2524(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Suzuki S. , Oldberg A. , Hayman E.G. , Pierschbacher M.D. , Ruoslahti E.
Submitted (1986-06) to the PIR data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion."
Jenne D.E. , Stanley K.K.
EMBO J.4:3153-3157(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the 'pexin' family and a model for their evolution."
Jenne D.E. , Stanley K.K.
Biochemistry26:6735-6742(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Mammary gland.
6.

SeattleSNPs variation discovery resource
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-122; GLN-268 AND MET-400
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-400
tissue: Lung.
8.

"Primary structure of somatomedin B: a growth hormone-dependent serum factor with protease inhibiting activity."
Fryklund L. , Sievertsson H.
FEBS Lett.87:55-60(1978) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-63
9.

"Identification of a PAI-1 binding site in vitronectin."
Sigurdardottir O. , Wiman B.
Biochim. Biophys. Acta1208:104-110(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-44;INTERACTION WITH SERPINE1/PAI1
10.

"Insulin binds to type V collagen with retention of mitogenic activity."
Yaoi Y. , Hashimoto K. , Takahara K. , Kato I.
Exp. Cell Res.194:180-185(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 360-368;INTERACTION WITH INSULIN
11.

"Phosphorylation of vitronectin by a protein kinase in human plasma. Identification of a unique phosphorylation site in the heparin-binding domain."
McGuire E.A. , Peacock M.E. , Inhorn R.C. , Siegel N.R. , Tollefsen D.M.
J. Biol. Chem.263:1942-1945(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 393-400;PHOSPHORYLATION AT SER-397
12.

Hochstrasser D.F. , Frutiger S. , Paquet N. , Bairoch A. , Ravier F. , Pasquali C. , Sanchez J.-C. , Tissot J.-D. , Bjellqvist B. , Vargas R. , Appel R.D. , Hughes G.J.
Submitted (1992-06) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 399-413
tissue: Plasma.
13.

"Sulfation of two tyrosine-residues in human complement S-protein (vitronectin)."
Jenne D.E. , Hille A. , Stanley K.K. , Huttner W.B.
Eur. J. Biochem.185:391-395(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION
14.

"The phosphorylation of the two-chain form of vitronectin by protein kinase A is heparin dependent."
Chain D. , Korc-Grodzicki B. , Kreizman T. , Shaltiel S.
FEBS Lett.269:221-225(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-397
15.

"Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin."
Seiffert D. , Loskutoff D.J.
J. Biol. Chem.266:2824-2830(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SERPINE1/PAI1
16.

"The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor."
Lim B.L. , Reid K.B. , Ghebrehiwet B. , Peerschke E.I. , Leigh L.A. , Preissner K.T.
J. Biol. Chem.271:26739-26744(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C1QBP
17.

"Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading."
Seger D. , Gechtman Z. , Shaltiel S.
J. Biol. Chem.273:24805-24813(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-69 AND THR-76;MUTAGENESIS OF THR-69 AND THR-76
18.

"Identification of the disulfide bonds in the recombinant somatomedin B domain of human vitronectin."
Kamikubo Y. , Okumura Y. , Loskutoff D.J.
J. Biol. Chem.277:27109-27119(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS IN SOMATOMEDIN-B
19.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-86; ASN-169 AND ASN-242
tissue: Plasma.
20.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-86; ASN-169 AND ASN-242
tissue: Plasma.
21.

"Phosphoproteomic analysis of the human pituitary."
Beranova-Giorgianni S. , Zhao Y. , Desiderio D.M. , Giorgianni F.
Pituitary9:109-120(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Pituitary.
22.

"Determination of the sites of tyrosine O-sulfation in peptides and proteins."
Yu Y. , Hoffhines A.J. , Moore K.L. , Leary J.A.
Nat. Methods4:583-588(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION AT TYR-75 AND TYR-78;PHOSPHORYLATION AT SER-312;GLYCOSYLATION AT ASN-86;IDENTIFICATION BY MASS SPECTROMETRY
23.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
24.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-86; ASN-169 AND ASN-242
tissue: Liver.
25.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-86 AND ASN-242
26.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.

"How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration."
Zhou A. , Huntington J.A. , Pannu N.S. , Carrell R.W. , Read R.J.
Nat. Struct. Biol.10:541-544(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 22-58 IN COMPLEX WITH SERPINE1/PAI1

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