Wapal ELISA Kit for Mouse(Mus musculus) | EIAab.comWapal ELISA Kit for Mouse(Mus musculus)

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Wapal (Gene name),

Wings apart-like protein homolog (Protein name ), WAPL_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Wapal(Kiaa0261;Wapl);

Protein name:

Wings apart-like protein homolog;

Alternative:

Dioxin-inducible factor 2(DIF-2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and soluble pools of the complex. Interacts with RAD21; the interaction is direct (By similarity). Interacts with PDS5A; the interaction is direct, cohesin-dependent and competitive with SORORIN (By similarity). Interacts (via FGF motifs) with PDS5B; the interaction is direct (By similarity). Interacts with SMC3.

Function:

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Subcellular Location:

Nucleus Chromosome Cytoplasm Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.

Protein Attributes:

Sequence length:

1200

Sequence:

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3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q65Z40

UniGene:

Mm.27957

Pfam:

PF07814

KEGG:

mmu:218914

String:

Q65Z40

Uniprot:

Q65Z40

FOR

ELISA Kit for Mouse Wings apart-like protein homolog

CLIA Kit for Mouse Wings apart-like protein homolog

Polyclonal Antibody for Mouse Wings apart-like protein homolog

Monoclonal Antibody for Mouse Wings apart-like protein homolog

Protein for Mouse Wings apart-like protein homolog

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis."
Kuroda M. , Oikawa K. , Ohbayashi T. , Yoshida K. , Yamada K. , Mimura J. , Matsuda Y. , Fujii-Kuriyama Y. , Mukai K.
FEBS Lett.579:167-172(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
2.

"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Embryonic tail.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
4.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
5.

"Wapl controls the dynamic association of cohesin with chromatin."
Kueng S. , Hegemann B. , Peters B.H. , Lipp J.J. , Schleiffer A. , Mechtler K. , Peters J.M.
Cell127:955-967(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THE COHESIN COMPLEX
6.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468 AND SER-470;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
7.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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